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Metabolic Syndrome, GERD, Barrett’s Esophagus

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Abstract

Gastroesophageal reflux disease (GERD) is on the rise with more than 20 % of the Western population reporting symptoms. GERD is the most common gastrointestinal disorder in the United States. This increase in GERD is not exactly clear but has been attributed to the increasing prevalence of obesity, changing diet, and perhaps the decreasing prevalence of Helicobacter pylori infection. Complications of GERD could be either benign or malignant. Benign complications include erosive esophagitis, bleeding, and peptic strictures. Premalignant and malignant lesions include Barrett’s metaplasia (BE), and esophageal cancer (EA). Metabolic syndrome is considered a state of chronic inflammation and is strongly associated with circulating levels of C-reactive protein (CRP) and fibrinogen. Chronic subclinical inflammation may be one pathophysiological mechanism explaining the increased risk of GERD and complications of GERD associated with metabolic syndrome. Moreover, among patients with BE, increased levels of leptin and insulin resistance are associated with increased risk for EA. A structured weight loss program can lead to resolution of GERD symptoms in the majority of patients.

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, University of Kansas Medical Center, Kansas City, KS, USA

    Sravanthi Parasa

  2. Department of Cardiovascular Medicine, Heart & Vascular Institute, Cleveland Clinic, Cleveland, OH, USA

    Arun Raghav MahankaliSridhar

Authors
  1. Sravanthi Parasa
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  2. Arun Raghav MahankaliSridhar
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Correspondence to Sravanthi Parasa .

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Editors and Affiliations

  1. Perelman School of Medicine, University of Pennsylvania, Pennsylania, Pennsylvania, USA

    Rexford S. Ahima

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© 2015 Springer International Publishing Switzerland

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Parasa, S., MahankaliSridhar, A.R. (2015). Metabolic Syndrome, GERD, Barrett’s Esophagus. In: Ahima, R. (eds) Metabolic Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-319-12125-3_37-1

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  • DOI: https://doi.org/10.1007/978-3-319-12125-3_37-1

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  • Publisher Name: Springer, Cham

  • Online ISBN: 978-3-319-12125-3

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