Stress, Kindling and PTSD: Typical Symptoms of Temporal Lobe Epilepsy and Antiepileptic Medication
According to recent reported findings, stress experiences are related to neurobiological processes that may have lasting consequences and significantly influence brain functions. These stress experiences may lead to cognitive and emotional dysregulation related to deficits in inhibitory functions and increased limbic excitability that may cause temporo-limbic seizure-like activity and specific changes in neural dynamics and complexity of neural networks. These findings indicate that stress-activated limbic kindling may be involved in the pathogenesis of post-traumatic stress disorder and some other psychiatric disorders which may explain the efficacy of antiepileptic drugs.
KeywordsAnticonvulsants PTSD Sensitization Stress Kindling
The study was supported by the grant GACR P407/12/1957 and the project “CEITEC – Central European Institute of Technology” (CZ.1.05/1.1.00/02.0068) from European Regional Development Fund.
- Anderson CM, Teicher MH, Polcari A, Renshaw PF. Abnormal T2 relaxation time in the cerebellar vermis of adults sexually abused in childhood: potential role of the vermis in stress-enhanced risk for drug abuse. Psychoneuroendocrinology. 2002;27:231–44.Google Scholar
- Baldwin DS, Anderson IM, Nutt DJ, et al. Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: a revision of the 2005 guidelines from the British Association for Psychopharmacology. J Psychopharmacol. 2014;28:403–39.CrossRefPubMedGoogle Scholar
- Berlin HA. Antiepileptic drugs for the treatment of post-traumatic stress disorder. Curr Psychiatry Rep. 2007;14:185–9.Google Scholar
- Gabriel A. Lamotrigine adjunctive treatment in resistant unipolar depression: an open, descriptive study. Depress Anxiety. 2006;23:485–8.Google Scholar
- Keller MB. Past, present, and future directions for defining optimal treatment outcome in depression: remission and beyond. JAMA. 2003;289:3152–60.Google Scholar
- Monroe SM, Harkness KL. Life stress, the “kindling” hypothesis, and the recurrence of depression: considerations from a life stress perspective. Psychol Rev. 2005;112:417–45.Google Scholar
- Morishita S. Clonazepam as a therapeutic adjunct to improve the management of depression: a brief review. Hum Psychopharmacol. 2009;24:191–8.Google Scholar
- Post RM, Weis SR, Smith MA. Sensitization and kindling. In: Friedman MJ, Charney DS, Deutch AY, editors. Neurobiological and clinical consequences of stress: from normal adaptation to posttraumatic stress disorder. Philadelphia: Lippincott-Raven; 1995.Google Scholar
- Putnam F. Dissociation in children and adolescents. A developmental perspective. London/New York: The Guilford Press; 1997.Google Scholar