Stress, Kindling and PTSD: Typical Symptoms of Temporal Lobe Epilepsy and Antiepileptic Medication

  • Petr BobEmail author
Reference work entry


According to recent reported findings, stress experiences are related to neurobiological processes that may have lasting consequences and significantly influence brain functions. These stress experiences may lead to cognitive and emotional dysregulation related to deficits in inhibitory functions and increased limbic excitability that may cause temporo-limbic seizure-like activity and specific changes in neural dynamics and complexity of neural networks. These findings indicate that stress-activated limbic kindling may be involved in the pathogenesis of post-traumatic stress disorder and some other psychiatric disorders which may explain the efficacy of antiepileptic drugs.


Anticonvulsants PTSD Sensitization Stress Kindling 



The study was supported by the grant GACR P407/12/1957 and the project “CEITEC – Central European Institute of Technology” (CZ.1.05/1.1.00/02.0068) from European Regional Development Fund.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Center for Neuropsychiatric Research of Traumatic Stress, Department of PsychiatryCharles University, First Faculty of MedicinePragueCzech Republic

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