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Pediatric Nephrologist and the Infant or Child Before Kidney Transplantation

  • Christopher LaRosa
Reference work entry
Part of the Organ and Tissue Transplantation book series (OTT)

Abstract

Renal transplantation is the standard of care for the management of pediatric end-stage renal disease. Many infants, children, and adolescents require dialysis prior to transplant, and due to this therapeutic modality, transplant is considered elective. However, significant short-term and long-term morbidities are associated with dialysis, especially when necessary for prolonged periods. For this reason, preemptive renal transplant is desirable when it can be planned. Most chronic kidney disease and end-stage renal disease in pediatrics is due to congenital structural abnormalities, although the predominant causes of renal disease vary by age, geography, and ethnicity. A substantial proportion of pediatric renal disease has a known genetic cause. Effective management of chronic kidney disease, specifically its complications, can have a significant impact on outcomes and potentially delay the onset of end-stage renal disease.

Keywords

End-stage renal disease Chronic kidney disease Renal replacement therapy Hemodialysis Peritoneal dialysis Hypertension Growth hormone Glomerular filtration rate Congenital abnormalities of the kidney and urinary tract Next-generation sequencing Steroid-resistant nephrotic syndrome Focal segmental glomerulosclerosis Glomerulonephritis Mineral and bone disease Angiotensin-converting enzyme inihibitor Angiotensin receptor blocker 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Nemours/Alfred I. duPont Hospital for ChildrenWilmingtonUSA

Section editors and affiliations

  • J Jeffrey Malatack
    • 1
  1. 1.Diagnostic Referral DivisionNemours/Alfred I. duPont Hospital for ChildrenWilmingtonUSA

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