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Optical Coherence Tomography for Gastrointestinal Endoscopy

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Optical Coherence Tomography

Abstract

Researchers have long been exploring OCT as a diagnostic tool for the early epithelial dysplastic changes in the gastrointestinal tract. One reason is that the subsurface microscopic changes are within the depth-penetrating and detail-resolving capability of OCT. However, endoscopically imaging a large lumen (i.e. esophagus and colon) has been challenging. In this chapter, the key technologies to overcome the obstacles are introduced: 1) Rapid imaging acquisition based on spectral-domain OCT technology; 2) Miniature scanning probe and balloon-based catheter for volumetric imaging; and 3) Image reconstruction and computer-aided diagnosis algorithms. Animal and clinical studies based on these technologies will be presented.

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Acknowledgements

The authors thank Michael W. Jenkins, Zhao Wang, Yinsheng Pan, Zhilin Hu, Gerard A. Isenberg, Amitabh Chak, and Michael Sivak. Some research presented here was supported in part by the National Institutes of Health (R01CA114276).

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Authors and Affiliations

  1. St. Jude Medical, Westford, MA, USA

    Wei Kang

  2. Rutgers University, Piscataway, NJ, USA

    Xin Qi

  3. American Medical Systems, San Jose, CA, USA

    Hui Wang

  4. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA

    Andrew M. Rollins

Authors
  1. Wei Kang
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  2. Xin Qi
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  3. Hui Wang
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  4. Andrew M. Rollins
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Correspondence to Wei Kang .

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Editors and Affiliations

  1. Center for Medical Physics and Biomedical Engineering, Medical University Vienna, General Hospital Vienna, Vienna, Austria

    Wolfgang Drexler

  2. Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    James G. Fujimoto

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Kang, W., Qi, X., Wang, H., Rollins, A.M. (2015). Optical Coherence Tomography for Gastrointestinal Endoscopy. In: Drexler, W., Fujimoto, J. (eds) Optical Coherence Tomography. Springer, Cham. https://doi.org/10.1007/978-3-319-06419-2_69

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