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MUW Approach of PS OCT

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Optical Coherence Tomography

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Abstract

Polarization sensitive (PS) OCT is a functional extension of OCT that exploits the light’s polarization state to generate intrinsic, tissue specific contrast and enables quantitative measurements of tissue parameters. This chapter explains the technique, discusses polarization-changing light-tissue interactions and demonstrates the application of PS-OCT to retinal imaging. Two polarization-changing light-tissue interactions are discussed and their use for retinal diagnostics are demonstrated: (i) birefringence, which is found in fibrous tissues like the retinal nerve fiber layer and can be used for glaucoma diagnostics; and (ii) depolarization, which is observed in the retinal pigment epithelium (RPE) and can be used to segment the RPE and associated lesions like drusen or geographic atrophies in age related macular degeneration.

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Acknowledgments

We thank B. Baumann, M. Bonesi, E. Götzinger, T. Torzicky, and S. Zotter, Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, and C. Ahlers, M. Bolz, J. Lammer, S. Michels, M. Ritter, P. Roberts, F. Schlanitz, C. Schütze, C. Vass, and U. Schmidt-Erfurth, Department of Ophthalmology, Medical University of Vienna, for cooperation. Part of this work was financially supported by the Austrian Science Fund (grants P16776 and P19624), by the European Commission (project FUN OCT, FP7 HEALTH, contract no. 201880), and by Canon Inc., Tokyo.

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  1. Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria

    Christoph K. Hitzenberger & Michael Pircher

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  1. Christoph K. Hitzenberger
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Correspondence to Christoph K. Hitzenberger .

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  1. Center for Medical Physics and Biomedical Engineering, Medical University Vienna, General Hospital Vienna, Vienna, Austria

    Wolfgang Drexler

  2. Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    James G. Fujimoto

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Hitzenberger, C.K., Pircher, M. (2015). MUW Approach of PS OCT. In: Drexler, W., Fujimoto, J. (eds) Optical Coherence Tomography. Springer, Cham. https://doi.org/10.1007/978-3-319-06419-2_35

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