Live Donor Intestinal Transplantation

  • Ivo Tzvetanov
  • Giuseppe D’Amico
  • Enrico Benedetti
Living reference work entry
Part of the Organ and Tissue Transplantation book series (OTT)

Abstract

Living donor intestinal transplantation (LDIT) has been perfected in relation to technical details, leading to results comparable to those obtained with deceased donors. Because the availability of adequate supply of intestinal deceased grafts, LDIT should be limited to specific indications. In particular, the best indication is probably combined living donor intestinal/liver transplantation (CLDILT) in pediatric recipients with intestinal and hepatic failure. In this setting, the virtual elimination of waiting time may avoid the high mortality currently experienced by candidates on the deceased waiting list. Isolated LDIT may be indicated for candidates to intestinal transplantation with lack of central venous access as a rapid rescue strategy. Potentially, LDIT could be also used in highly sensitized recipients to allow the application of desensitization protocols. Finally, in the specific case of available identical twins or HLA-identical sibling, LDIT has a significant immunological advantage and should be offered.

Keywords

Intestinal failure Pediatric recipients Living donor small bowel transplantation Combined living donor intestinal/liver transplantation 

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Ivo Tzvetanov
    • 1
  • Giuseppe D’Amico
    • 1
  • Enrico Benedetti
    • 1
  1. 1.Division of Transplantation, Department of SurgeryUniversity of Illinois at ChicagoChicagoUSA

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