Anti-Epileptic Activity

  • Mary Jeanne Kallman
Reference work entry


Epilepsy is a disease of high prevalence, being well known since thousands of years as “morbus sacer.” In spite of intensive investigations, the pathophysiology of epilepsy is still poorly understood. Studies with various animal models have provided ample evidence for heterogeneity in the mechanisms of epileptogenesis. New evidence derives from investigations of kindling, which involves the delivery of brief, initially subliminal, electrical, or chemical stimuli to various areas of the brain. After 10–15 days of once-daily stimulation, the duration and intensity of afterdischarges reach a stable maximum, and a characteristic seizure is produced. Subsequent stimulation then regularly elicits seizures.

References and Further Reading

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4-Aminopyridine-Induced Seizures in Mice

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3-Nitropropionic Acid-Induced Seizures in Mice

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Epilepsy Induced by Focal Lesions

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Kindled Rat Seizure Model

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Posthypoxic Myoclonus in Rats

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Rat Kainate Model of Epilepsy

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Pilocarpine Model of Epilepsy

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Self-Sustained Status Epilepticus

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Rat Model of Cortical Dysplasia

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Kallman Preclinical ConsultingGreenfieldUSA

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