Patch-Clamp and Voltage-Clamp Techniques

  • Michael Gralinski
  • Liomar A. A. Neves
  • Olga Tiniakova
Reference work entry


The introduction of the patch-clamp technique (Neher and Sakmann 1976) revolutionized the study of cellular physiology by providing a high-resolution method of observing the function of individual ionic channels in a variety of normal and pathological cell types. By the use of variations of the basic recording methodology, cellular function and regulation can be studied at a molecular level by observing currents through individual ionic channels (Liem et al. 1995; Sakmann and Neher 1995).


Cystic Fibrosis Transmembrane Conductance Regulator Xenopus Oocyte Patch Pipette Tyrode Solution Borosilicate Glass Capillary 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References and Further Reading

Patch-Clamp Technique

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Patch Clamp Technique in Isolated Cardiac Myocytes

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Voltage Clamp Studies on Sodium Channels

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Voltage Clamp Studies on Potassium Channels

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Studies on Kv1.5 Channel

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Voltage Clamp Studies on Calcium Channels

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Michael Gralinski
    • 1
  • Liomar A. A. Neves
    • 1
  • Olga Tiniakova
    • 1
  1. 1.CorDynamics, Inc.ChicagoUSA

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