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Drug Discovery and Evaluation: Pharmacological Assays pp 555–566Cite as

Na+/H+ Exchange

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Abstract

Na+/H+ exchange was first described by Murer et al. (1976) in a study of intestinal and renal brush-border vesicles. The plasma membrane Na/H exchanger is an ubiquitous pH-regulating cellular ion transport system. It is driven by the Na+ gradient and extrudes protons from the cytosol in exchange for extracellular Na+ ions (Aronson 1985; Frelin et al. 1988; Fliegel and Dyck 1995; Orlowski and Grinstein 1997; Wakabayshi et al. 1997; Dibrov and Fliegel 1998). Six mammalian Na+/H+ exchangers, NHE1, NHE2, NHE3, NHE4, NHE5 (Attaphitaya et al. 1999; Szabo et al. 2000), and NHE6, have been described (Tse et al. 1994; Orlowski 1999; Counillon and Pouysségur 2000).

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  1. CorDynamics, Inc., 2242 W. Harrison St., Suite 108, Chicago, IL, 60612, USA

    Michael Gralinski, Liomar A. A. Neves & Olga Tiniakova

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  1. Michael Gralinski
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  2. Liomar A. A. Neves
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  3. Olga Tiniakova
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Correspondence to Michael Gralinski .

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  1. CorDynamics, Dieburg, Germany

    Franz J. Hock

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Gralinski, M., Neves, L.A.A., Tiniakova, O. (2016). Na+/H+ Exchange. In: Hock, F. (eds) Drug Discovery and Evaluation: Pharmacological Assays. Springer, Cham. https://doi.org/10.1007/978-3-319-05392-9_144

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