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Biomolecule Adsorption and Release from Porous Silicon

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Handbook of Porous Silicon

Abstract

Pore size, surface chemistry, and surface area are the three most important criteria to consider when designing a porous silicon (pSi) biomolecule carrier matrix, and their effects are reviewed. Matrices possessing optimum pore diameter distributions facilitate restricted diffusion of small and large biomolecules into and out of the pores. Thermal oxidation is a popular means to remove reactive hydride species from the surface which would otherwise denature adsorbed biomolecules. Hydrophilic/hydrophobic characteristics of the pSi surface can be tuned to facilitate “ordered” adsorption of a protein and improve its stability. The physiochemical properties of a biomolecule also dictate protein-surface interaction. Moreover, the size (hydrodynamic radius) and shape (globular, fibrous, etc.) of biomolecules also govern their mobility and arrangement on the surface.

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Authors and Affiliations

  1. Psivida Corp, Malvern, Worcestershire, UK

    Dinesh Nadarassan

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  1. Dinesh Nadarassan
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Correspondence to Dinesh Nadarassan .

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  1. Malvern Hills Science Park, Chief Scientific Officer, Intrinsiq Mate, Malvern, Worcestershire, United Kingdom

    Leigh Canham

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Nadarassan, D. (2016). Biomolecule Adsorption and Release from Porous Silicon. In: Canham, L. (eds) Handbook of Porous Silicon. Springer, Cham. https://doi.org/10.1007/978-3-319-04508-5_124-1

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  • DOI: https://doi.org/10.1007/978-3-319-04508-5_124-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-04508-5

  • Online ISBN: 978-3-319-04508-5

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