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Diagnosis and Management of Vaginal Cancer

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Handbook of Gynecology

Abstract

Primary malignancies of the vagina are rare, comprising only about 1–4% of all gynecologic malignancies. The majority of vaginal cancers are metastases from other sites. Among primary vaginal tumors, squamous cell carcinoma is the most common, followed by adenocarcinoma, melanoma, and other rare histologies. Squamous cell carcinomas are frequently associated with chronic HPV infection, whereas adenocarcinomas are associated with in utero DES exposure. Vaginal intraepithelial neoplasia is a premalignant condition thought to progress to invasive squamous cell carcinoma if untreated. Vaginal intraepithelial neoplasia is generally asymptomatic, and diagnosed by abnormal vaginal cytology followed by vaginal colposcopy and biopsies. Most vaginal cancers present with abnormal vaginal bleeding or a vaginal mass. Diagnosis is made by physical exam and confirmatory biopsy. Treatment of vaginal cancer depends on the primary histology, stage at diagnosis, and patient characteristics. Treatment options include surgical excision, radiation therapy, and chemotherapy. The majority of vaginal cancers are treated with radiation, frequently in combination with chemotherapy. Prognosis varies depending on underlying histology and stage at presentation; however, with advances in radiation techniques, survival rates are similar to those seen in cervical cancer.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Stanford University, Palo Alto, CA, USA

    E. Clair McClung

  2. Department of Pathology, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA

    Ardeshir Hakam

  3. Department of Gynecologic Oncology, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA

    Mian M. K. Shahzad

Authors
  1. E. Clair McClung
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  2. Ardeshir Hakam
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  3. Mian M. K. Shahzad
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Corresponding author

Correspondence to E. Clair McClung .

Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Donna Shoupe

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McClung, E.C., Hakam, A., Shahzad, M.M.K. (2023). Diagnosis and Management of Vaginal Cancer. In: Shoupe, D. (eds) Handbook of Gynecology. Springer, Cham. https://doi.org/10.1007/978-3-031-14881-1_8

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  • DOI: https://doi.org/10.1007/978-3-031-14881-1_8

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-14880-4

  • Online ISBN: 978-3-031-14881-1

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