Abstract
Since its first discovery in 1930, immunohistochemistry (IHC) has become an important staple in all pathology departments. Its usage gained popularity in early 1970 when the “immunoperoxidase” method to produce formalin paraffin-embedded tissues was developed. This ancillary technology has become a routine and essential tool in diagnostic and research laboratories. Application of IHC in medical practice is commonly used in helping to identify the origin of malignancy, predicting prognosis, and helping select targeted therapy. Gynecologic pathology is not an exception. Example and just to name a few, pair box gene 8 (PAX8) has been used to identify the Müllerian origin of a carcinoma while alpha-inhibin and calretinin identifies sex cord tumors. This chapter will describe the principles and the interpretation of IHC and discuss various immunomarkers that are commonly used in gynecologic pathology.
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Wang, Y., Mhawech-Fauceglia, P. (2023). Immunohistochemistry of Gynecologic Malignancies. In: Shoupe, D. (eds) Handbook of Gynecology. Springer, Cham. https://doi.org/10.1007/978-3-031-14881-1_65
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DOI: https://doi.org/10.1007/978-3-031-14881-1_65
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