Skip to main content
SpringerLink
Log in

Diagnosis and Management of the Cancer of the Uterus

  • Reference work entry
  • First Online:
Handbook of Gynecology

  • 413 Accesses

Abstract

Uterine cancer is the most common malignancy of the female genital tract. Treatment of uterine cancer is related to cell type, grade, and stage. However, the vast majority of uterine cancers will be low grade, early-stage endometrial cancers with obesity being the primary risk factor associated with these cancers. Surgery is an important part of staging and management of uterine cancers.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 999.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 999.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Amant F, Floquet A, Friedlander M, Kristensen G, Mahner S, Nam EJ, Powell MA, Ray-Coquard I, Siddiqui N, Sykes P, Westermann AM, Seddon B. Gynecologic Cancer InterGroup (GCIG) consensus review for endometrial stromal sarcoma. Int J Gynecol Cancer. 2014;24(9 Suppl 3):S67–72.

    Article  PubMed  Google Scholar 

  • American College of Obstetricians and Gynecologists. Lynch syndrome. Practice bulletin no. 147. Obstet Gynecol. 2014;124:1042–54.

    Article  Google Scholar 

  • Cantrell LA, Havrilesky L, Moore DT, O’Malley D, Liotta M, Secord AA, Nagel CI, Cohn DE, Fader AN, Wallace AH, Rose P, Gehrig PA. A multi-institutional cohort study of adjuvant therapy in stage I-II uterine carcinosarcoma. Gynecol Oncol. 2012;127(1):22.

    Article  PubMed  Google Scholar 

  • Cowden syndrome – Genetics Home Reference. 2014;1–7. http://ghr.nlm.nih.gov/condition/cowden-syndrome. Accessed 20 Jan 14.

  • Creutzberg CL, van Putten WL, Koper PC, Lybert ML, et al. Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post operative radiation therapy in endometrial carcinoma. Lancet. 2000;355:1404–11.

    Article  CAS  PubMed  Google Scholar 

  • D’Angelo E, Prat J. Uterine sarcomas: a review. Gynecol Oncol. 2009:1–9. https://doi.org/10.1016/j.ygyno.2009.09.023.

  • Decruze SB, Green JA. Hormone therapy in advanced and recurrent endometrial cancer: a systematic review. Int J Gynecol Cancer. 2007;17:964.

    Article  CAS  PubMed  Google Scholar 

  • Fader AN, Drake RD, O’Malley DM, Gibbons HE, Huh WK, Havrilesky LJ, et al. Platinum/taxane based chemotherapy with or without radiotherapy favorably impacts survival outcomes in stage I uterine papillary serous carcinoma. Cancer. 2009;115:2119–27.

    Article  CAS  PubMed  Google Scholar 

  • Friedlander ML, Covens A, Glasspool RM, Hilpert F, Kristensen G, Kwon S, Selle F, Small W, Witteveen E, Russell P. Gynecologic Cancer InterGroup (GCIG) consensus review for mullerian adenosarcoma of the female genital tract. Int J Gynecol Cancer. 2014;24(9 Suppl 3):S78–82.

    Article  PubMed  Google Scholar 

  • Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61(2):69–90. https://doi.org/10.3322/caac.20107.

    Article  PubMed  Google Scholar 

  • Kapp DS, Shin JY, Chan JK. Prognostic factors and survival in 1396 patients with uterine leiomyosarcomas: emphasis on impact of lymphadenectomy and oophorectomy. Cancer. 2008;112(4):820.

    Article  PubMed  Google Scholar 

  • Keys HM, Roberts JA, Brunetto VL, Zaino RJ, Spirtos NM, Bloss JD, Pearlman A, Bell JG. A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study. Gynecol Oncol. 2004;92(3):744–51.

    Article  PubMed  Google Scholar 

  • Lau HY, Twu NF, Yen MS, Tsai HW, Wang PH, Chuang CM, Wu HH, Chao KC, Chen YJ. Impact of ovarian preservation in women with endometrial cancer. J Chin Med Assoc. 2014;77(7):379–84.

    Article  PubMed  Google Scholar 

  • Lee TS, Lee JY, Kim JW, Oh S, Seong SJ, Lee JM, Kim TJ, Cho CH, Kim SM, Park CY. Outcomes of ovarian preservation in a cohort of premenopausal women with early-stage endometrial cancer: a Korean Gynecologic Oncology Group study. Gynecol Oncol. 2013;131(2):289–93.

    Article  PubMed  Google Scholar 

  • Lynch syndrome – Genetics home reference. 2014;1–7. http://ghr.nlm.nih.gov/condition/lynch-syndrome. Accessed 20 Jan 14.

  • Major FJ, Blessing JA, Silverberg SG, Morrow CP, Creasman WT, Currie JL, Yordan E, Brady MF. Prognostic factors in early-stage uterine sarcoma. A Gynecologic Oncology Group study. Cancer. 1993;71(Suppl 4):1702.

    Article  CAS  PubMed  Google Scholar 

  • Mariani A, Sebo TJ, Katzmann JA, Keeney GL, Roche PC, Lesnick TG, Podratz KC. Pretreatment assessment of prognostic indicators in endometrial cancer. Am J Obstet Gynecol. 2000;182(6):1535–44.

    Article  CAS  PubMed  Google Scholar 

  • Mutch DG. The new FIGO staging system for cancers of the vulva, cervix, endometrium, and sarcomas. Gynecol Oncol. 2009;115:325–8.

    Article  Google Scholar 

  • NCCN. Uterine neoplasm. 2012;1–63.

    Google Scholar 

  • Omura GA, Blessing JA, Major F, Lifshitz S, Ehrlich CE, Mangan C, Beecham J, Park R, Silverberg S. A randomized clinical trial of adjuvant adriamycin in uterine sarcomas: a Gynecologic Oncology Group Study. J Clin Oncol. 1985;3(9):1240.

    Article  CAS  PubMed  Google Scholar 

  • Pautier P, Nam EJ, Provencher DM, Hamilton AL, Mangili G, Siddiqui NA, Westermann AM, Reed NS, Harter P, Ray-Coquard I. Gynecologic Cancer InterGroup (GCIG) consensus review for high-grade undifferentiated sarcomas of the uterus. Int J Gynecol Cancer. 2014;24(9 Suppl 3):S73–7.

    Article  PubMed  Google Scholar 

  • Rauh-Hain JA, Growdon WB, Schorge JO, Goodman AK, Boruta DM, McCAnn C, et al. Prognostic determinants in patients with stage IIIC-Iv uterine papillary serous carcinoma. Gynecol Oncol. 2010;119:299–304.

    Article  PubMed  Google Scholar 

  • Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet. 2008;371(9612):569–78. https://doi.org/10.1016/S0140-6736(08)60269-X.

    Article  PubMed  Google Scholar 

  • Retinoblastoma – Genetics home reference. 2014;1–4. http://ghr.nlm.nih.gov/condition/retinoblastoma. Accessed 20 Jan 14.

  • Seamon LG, Cohn DE, Henretta MS, Kim KH, Carlson MJ, Phillips GS, Fowler JM. Minimally invasive comprehensive surgical staging for endometrial cancer: robotics or laparoscopy? Gynecol Oncol. 2009;113(1):36–41.

    Article  PubMed  Google Scholar 

  • SEER. Cancer of the endometrium – SEER Stat Fact Sheets. 2013. 1–10. http://seer.cancer.gov/statfacts/html/corp.html. Accessed 20 Jan 14.

  • Sorosky JI. Endometrial cancer. Obstet Gynecol. 2012;120(2, Part 1):383–97. https://doi.org/10.1097/AOG.0b013e3182605bf1.

    Article  PubMed  Google Scholar 

  • Tanner EJ, Leitao MM Jr, Garg K, Chi DS, Sonoda Y, Gardner GJ, Barakat RR, Jewell EL. The role of cytoreductive surgery for newly diagnosed advanced-stage uterine carcinosarcoma. Gynecol Oncol. 2011;123(3):548–52.

    Article  PubMed  Google Scholar 

  • Thigpen T, Brady MF, Homesley HD, et al. Tamoxifen in the treatment of advanced or recurrent endometrial carcinoma: a Gynecologic Oncology Group Study. J Clin Oncol. 2001;19:364.

    Article  CAS  PubMed  Google Scholar 

  • Trimble CL, Kauderer J, Zaino R, et al. Concurrent endometrial carcinoma in women with a biopsy diagnosis of atypical endometrial hyperplasia. Cancer. 2006;106(4):812–9. https://doi.org/10.1002/cncr.21650.

    Article  PubMed  Google Scholar 

  • Trimble CL, Method M, Leitao M, et al. Management of endometrial precancers. Obstet Gynecol. 2012;120(5):1160. https://doi.org/10.1097/AOG.0b013e31826bb121.

    Article  PubMed  PubMed Central  Google Scholar 

  • Walker JL, Piedmonte MR, Spirtos NM, Eisenkop SM, Schlaerth JB, Mannel RS, Barakat R, Pearl ML, Sharma SK. Recurrence and survival after random assignment to laparoscopy versus laparotomy for comprehensive surgical staging of uterine cancer: Gynecologic Oncology Group LAP2 Study. J Clin Oncol. 2012;30(13):695–700.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wright JD, Buck AM, Shah M, Burke WM, Schiff PB, Herzog TJ. Safety of ovarian preservation in premenopausal women with endometrial cancer. J Clin Oncol. 2009;27(8):1214–9.

    Article  PubMed  Google Scholar 

  • Zullo F, Falbo A, Palomba S. Safety of laparoscopy vs laparotomy in the surgical staging of endometrial cancer: a systematic review and metaanalysis of randomized controlled trials. Am J Obstet Gynecol. 2012;207(2):94–100.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, West Virginia University, Morgantown, WV, USA

    Kristy K. Ward

  2. WellStar Gynecologic Oncology, Austell, GA, USA

    Amy R. Carroll

Authors
  1. Kristy K. Ward
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Amy R. Carroll
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kristy K. Ward .

Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

    Donna Shoupe

Rights and permissions

Reprints and permissions

Copyright information

© 2023 Springer Nature Switzerland AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Ward, K.K., Carroll, A.R. (2023). Diagnosis and Management of the Cancer of the Uterus. In: Shoupe, D. (eds) Handbook of Gynecology. Springer, Cham. https://doi.org/10.1007/978-3-031-14881-1_2

Download citation

  • DOI: https://doi.org/10.1007/978-3-031-14881-1_2

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-031-14880-4

  • Online ISBN: 978-3-031-14881-1

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation