Epithelioid Trophoblastic Tumor
Definition
Epithelioid trophoblastic tumor (ETT) is a malignant gestational trophoblastic neoplasm composed of chorionic-type intermediate trophoblast.
Clinical Features
Incidence
ETT is rare, accounting for between <1% and 2% of gestational trophoblastic tumors with an incidence rate of 0.04 per 100,000 deliveries (Lybol et al. 2011).
Age
Most ETT arise in patients of reproductive age but rare cases are reported after menopause (Fadare et al. 2006; Lybol et al. 2011). The preceding gestation is most commonly a full-term viable pregnancy (>50%), with a subset of ETT following a hydatidiform mole (up to 37%) or spontaneous abortion. The latency interval following the prior gestation ranges from 1–18 years with an average of 76 months (Davis et al. 2015).
Sex
Female.
Site
ETT typically arises in the lower uterine segment or endocervix (50%), in the uterine corpus (30%) or in extrauterine sites (20%), such as the broad ligament, para-adnexal tissue,...
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Rabban, J.T., Ladwig, N.R. (2023). Gestational Trophoblastic Neoplasms, Pathology of the Placenta. In: Stolnicu, S., Ali-Fehmi, R. (eds) Gynecologic Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-97378-0_5684
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