Adenomatoid Tumor
Definition
Benign tumor of mesothelial origin.
Clinical Features
Incidence
Infrequent. Adenomatoid tumors may disproportionately occur in immunocompromised patients.
Age
Middle-aged patients, 28–68 years.
Sex
Female and male.
Site
In the female, adenomatoid tumors most commonly occur in the myometrium and the fallopian tube wall, but may rarely arise in the ovary, the omentum, the bowel mesentery, and the peritoneum. In the male, adenomatoid tumors may be located in the epididymis and less commonly in the spermatic cord, prostate, and ejaculatory ducts.
Treatment
Usually an incidental finding at surgery for other indications.
Outcome
This is a benign tumor.
Macroscopy
Well circumscribed and usually not exceeding 2 cm in size. Typically located subjacent to serosal surfaces.
Microscopy
Composed of pseudoglandular and pseudovascular spaces lined by flat to cuboidal cells (Fig. 1). The spaces may be small and anastomosing or large and pseudocystic. Occasionally,...
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References and Further Reading
Alakus, H., Yost, S. E., Woo, B., French, R., Lin, G. Y., Jepsen, K., Frazer, K. A., et al. (2015). BAP1 mutation is a frequent somatic event in peritoneal malignant mesothelioma. Journal of Translational Medicine, 13, 122.
Alexander, H. R., Jr., Li, C. Y., & Kennedy, T. J. (2018). Current management and future opportunities for peritoneal metastases: Peritoneal mesothelioma. Annals of Surgical Oncology, 25, 2159–2164.
Andrici, J., Jung, J., Sheen, A., D’Urso, L., Sioson, L., Pickett, J., Parkhill, T. R., et al. (2016). Loss of BAP1 expression is very rare in peritoneal and gynecologic serous adenocarcinomas and can be useful in the differential diagnosis with abdominal mesothelioma. Human Pathology, 51, 9–15.
Baker, P. M., Clement, P. B., & Young, R. H. (2005). Malignant peritoneal mesothelioma in women: A study of 75 cases with emphasis on their morphologic spectrum and differential diagnosis. American Journal of Clinical Pathology, 123, 724–737.
Berzenji, L., & Van Schil, P. (2018). Multimodality treatment of malignant pleural mesothelioma. F1000Research, 7, F1000 Faculty Rev-1681. https://doi.org/10.12688/f1000research.15796.1.
Cerruto, C. A., Brun, E. A., Chang, D., & Sugarbaker, P. H. (2006). Prognostic significance of histomorphologic parameters in diffuse malignant peritoneal mesothelioma. Archives of Pathology & Laboratory Medicine, 130, 1654–1661.
Chen, X., Sheng, W., & Wang, J. (2013). Well-differentiated papillary mesothelioma: A clinicopathological and immunohistochemical study of 18 cases with additional observation. Histopathology, 62, 805–813.
Churg, A., & Galateau-Salle, F. (2012). The separation of benign and malignant mesothelial proliferations. Archives of Pathology & Laboratory Medicine, 136, 1217–1226.
Clement, P. B., Young, R. H., & Scully, R. E. (1996). Malignant mesotheliomas presenting as ovarian masses. A report of nine cases, including two primary ovarian mesotheliomas. The American Journal of Surgical Pathology, 20, 1067–1080.
Craig, J. R., & Hart, W. R. (1979). Extragenital adenomatoid tumor: Evidence for the mesothelial theory of origin. Cancer, 43, 1678–1681.
Desmeules, P., Joubert, P., Zhang, L., Al-Ahmadie, H. A., Fletcher, C. D., Vakiani, E., Delair, D. F., et al. (2017). A subset of malignant mesotheliomas in young adults are associated with recurrent EWSR1/FUS-ATF1 fusions. The American Journal of Surgical Pathology, 41, 980–988.
Enomoto, L. M., Shen, P., Levine, E. A., & Votanopoulos, K. I. (2019). Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for peritoneal mesothelioma: Patient selection and special considerations. Cancer Management and Research, 11, 4231–4241.
Goode, B., Joseph, N. M., Stevers, M., Van Ziffle, J., Onodera, C., Talevich, E., Grenert, J. P., et al. (2018). Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation. Modern Pathology, 31, 660–673.
Hoekstra, A. V., Riben, M. W., Frumovitz, M., Liu, J., & Ramirez, P. T. (2005). Well-differentiated papillary mesothelioma of the peritoneum: a pathological analysis and review of the literature. Gynecologic Oncology, 98, 161–167.
Hung, Y. P., Dong, F., Watkins, J. C., Nardi, V., Bueno, R., Dal Cin, P., Godleski, J. J., et al. (2018). Identification of ALK rearrangements in malignant peritoneal mesothelioma. JAMA Oncology, 4, 235–238.
Joseph, N. M., Chen, Y. Y., Nasr, A., Yeh, I., Talevich, E., Onodera, C., Bastian, B. C., et al. (2017). Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X. Modern Pathology, 30, 246–254.
Kerrigan, S. A., Turnnir, R. T., Clement, P. B., Young, R. H., & Churg, A. (2002). Diffuse malignant epithelial mesotheliomas of the peritoneum in women: A clinicopathologic study of 25 patients. Cancer, 94, 378–385.
Keshava, H. B., Tang, A., Siddiqui, H. U., Raja, S., Raymond, D. P., Bribriesco, A., Stevenson, J., et al. (2019). Largely unchanged annual incidence and overall survival of pleural mesothelioma in the USA. World Journal of Surgery, 43, 3239–3247.
Kim, J., Bhagwandin, S., & Labow, D. M. (2017). Malignant peritoneal mesothelioma: A review. The Annals of Translational Medicine, 5, 236. https://doi.org/10.21037/tlcr.2018.10.04.
Leblay, N., Lepretre, F., Le Stang, N., Gautier-Stein, A., Villeneuve, L., Isaac, S., Maillet, D., et al. (2017). BAP1 is altered by copy number loss, mutation, and/or loss of protein expression in more than 70% of malignant peritoneal mesotheliomas. Journal of Thoracic Oncology, 12, 724–733.
Liu, S., Staats, P., Lee, M., Alexander, H. R., & Burke, A. P. (2014). Diffuse mesothelioma of the peritoneum: Correlation between histological and clinical parameters and survival in 73 patients. Pathology, 46, 604–609.
Malpica, A., Sant’Ambrogio, S., Deavers, M. T., & Silva, E. G. (2012). Well-differentiated papillary mesothelioma of the female peritoneum: A clinicopathologic study of 26 cases. The American Journal of Surgical Pathology, 36, 117–127.
Markowitz, S. (2015). Asbestos-related lung cancer and malignant mesothelioma of the pleura: Selected current issues. Seminars in Respiratory and Critical Care Medicine, 36, 334–346.
Ordonez, N. G. (2013a). Application of immunohistochemistry in the diagnosis of epithelioid mesothelioma: A review and update. Human Pathology, 44, 1–19.
Ordonez, N. G. (2013b). Value of claudin-4 immunostaining in the diagnosis of mesothelioma. American Journal of Clinical Pathology, 139, 611–619.
Panou, V., Gadiraju, M., Wolin, A., Weipert, C. M., Skarda, E., Husain, A. N., Patel, J. D., et al. (2018). Frequency of germline mutations in cancer susceptibility genes in malignant mesothelioma. Journal of Clinical Oncology, 36, 2863–2871.
Pavlisko, E. N., Liu, B., Green, C., Sporn, T. A., & Roggli, V. L. (2020). Malignant diffuse mesothelioma in women: A study of 354 cases. The American Journal of Surgical Pathology, 44, 293–304.
Pillappa, R., Maleszewski, J. J., Sukov, W. R., Bedroske, P. P., Greipp, P. T., Boland, J. M., Yi, E. S., et al. (2018). Loss of BAP1 expression in atypical mesothelial proliferations helps to predict malignant mesothelioma. The American Journal of Surgical Pathology, 42, 256–263.
Sangoi, A. R., McKenney, J. K., Schwartz, E. J., Rouse, R. V., & Longacre, T. A. (2009). Adenomatoid tumors of the female and male genital tracts: a clinicopathological and immunohistochemical study of 44 cases. Modern Pathology, 22, 1228–1235.
Shrestha, R., Nabavi, N., Volik, S., Anderson, S., Haegert, A., McConeghy, B., Sar, F., et al. (2020). Well-differentiated papillary mesothelioma of the peritoneum is genetically distinct from malignant mesothelioma. Cancers (Basel), 12, 1568.
Stevers, M., Rabban, J. T., Garg, K., Van Ziffle, J., Onodera, C., Grenert, J. P., Yeh, I., et al. (2019). Well-differentiated papillary mesothelioma of the peritoneum is genetically defined by mutually exclusive mutations in TRAF7 and CDC42. Modern Pathology, 32, 88–99.
Sun, M., Zhao, L., Weng Lao, I., Yu, L., & Wang, J. (2019). Well-differentiated papillary mesothelioma: A 17-year single institution experience with a series of 75 cases. Annals of Diagnostic Pathology, 38, 43–50.
Tamura, D., Maeda, D., Halimi, S. A., Okimura, M., Kudo-Asabe, Y., Ito, S., Sato, N., et al. (2018). Adenomatoid tumour of the uterus is frequently associated with iatrogenic immunosuppression. Histopathology, 73, 1013–1022.
Tandon, R. T., Jimenez-Cortez, Y., Taub, R., & Borczuk, A. C. (2018). Immunohistochemistry in peritoneal mesothelioma: A single-center experience of 244 cases. Archives of Pathology & Laboratory Medicine, 142, 236–242.
Testa, J. R., Cheung, M., Pei, J., Below, J. E., Tan, Y., Sementino, E., Cox, N. J., et al. (2011). Germline BAP1 mutations predispose to malignant mesothelioma. Nature Genetics, 43, 1022–1025.
Xing, D., Banet, N., Sharma, R., Vang, R., Ronnett, B. M., & Illei, P. B. (2018). Aberrant Pax-8 expression in well-differentiated papillary mesothelioma and malignant mesothelioma of the peritoneum: A clinicopathologic study. Human Pathology, 72, 160–166.
Yeh, C. J., Chuang, W. Y., Chou, H. H., Jung, S. M., & Hsueh, S. (2008). Multiple extragenital adenomatoid tumors in the mesocolon and omentum. Acta Pathologica, Microbiologica, et Immunologica Scandinavica, 116, 1016–1019.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 Springer Nature Switzerland AG
About this entry
Cite this entry
Davidson, B., Djordjevic, B. (2023). Mesothelial Tumors, Pathology of the Peritoneum. In: Stolnicu, S., Ali-Fehmi, R. (eds) Gynecologic Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-97378-0_5674
Download citation
DOI: https://doi.org/10.1007/978-3-030-97378-0_5674
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-97377-3
Online ISBN: 978-3-030-97378-0
eBook Packages: MedicineReference Module Medicine