Brenner Tumors, Pathology of the Ovary

Benign Brenner Tumor

Definition

Benign Brenner tumor is a rare neoplasm with unknown etiology, deriving through metaplasia of the ovarian surface epithelium, from metaplastic transitional epithelium (Walthard nests) located in the hilar region of the ovary or beneath the serosa of the fallopian tube or from a teratoma. Benign Brenner tumor is composed of bland transitional-type epithelium, proliferating in a dense fibromatous stroma.

Clinical Features

• Incidence

  Benign Brenner tumor is a rare condition in the ovary representing approximately 5% of all benign epithelial tumors (Herrington et al. 2020).

• Age

  The tumor usually occurs in adult patients (fifth–seventh decade of life) but can develop at any age (Herrington et al. 2020).

• Sex

  Female.

• Site

  Ovary.

• Treatment

  Surgical excision is indicated and is curative.

• Outcome

  The tumor has no risk of recurrence or progression.

Macroscopy

Benign Brenner tumor is usually unilateral (with less than 10% being bilateral) and small (<2 cm), being...