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Diosmin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology

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  • First Online:
Handbook of Dietary Flavonoids

Abstract

This chapter will cover the advancement in the research on diosmin, based, mainly, in the last two decades. Diosmin, a flavone glycoside belonging to the class of flavonoids, secondary metabolites present in a huge number in plants and vegetables, has attracted researchers’ attention due to its potential involvement in human wellness. In particular, diosmin is the glycoside of the aglycon diosmetin (3′, 5, 7-trihydroxy-4′-methoxyflavone) that occurs naturally and abundant in citrus fruits and in several herbal preparations and it plays an important role in the treatment of various ailments. Numerous in vitro and in vivo studies have highlighted its biological roles with remarkable antioxidative, antihyperglycemic, anti-inflammatory, anticancer, and antimicrobial activity, just to mention a few, and its utilization as phlebotonic agent. We have provided, in this chapter, an overview of diosmin, focalizing on its chemistry, biochemistry, and pharmacology, based on its major biological properties on its therapeutic applications and, potential targets of action, following activation/block of the pathways associated with its utilization.

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Authors and Affiliations

  1. Dipartimento di Scienze biomediche, odontoiatriche e delle immagini morfologiche e funzionali, University of Messina, Messina, Italy

    Teresa Gervasi

  2. Dipartimento di Scienze Chimiche, biologiche, farmaceutiche ed ambientali, Università di Messina, Messina, Italy

    Giuseppe Tancredi Patanè, Antonella Calderaro, Giuseppina Mandalari & Davide Barreca

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  1. Teresa Gervasi
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  5. Davide Barreca
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Correspondence to Davide Barreca .

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  1. Department of Analytical Chemistry and Food Science, Universidade de Vigo, Vigo, Spain

    Jianbo Xiao

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Gervasi, T., Patanè, G.T., Calderaro, A., Mandalari, G., Barreca, D. (2023). Diosmin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology. In: Xiao, J. (eds) Handbook of Dietary Flavonoids. Springer, Cham. https://doi.org/10.1007/978-3-030-94753-8_7-1

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  • DOI: https://doi.org/10.1007/978-3-030-94753-8_7-1

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  • Print ISBN: 978-3-030-94753-8

  • Online ISBN: 978-3-030-94753-8

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