Abstract
Apigenin is an important flavone widespread in the plant kingdom. It displays a broad range of pharmacological properties and health beneficial effects suggesting a promising therapeutic potential in a wide variety of human chronic diseases, mainly cancer, neurodegenerative, and cardiometabolic disorders. Apigenin is a pleiotropic modulator of manifold signal cellular pathways interfering the function of numerous molecular targets such as transcriptional and growth factors, cytokines, receptors, and enzymes. This chapter provides an overview of apigenin focusing on its bioactivity, molecular mechanisms, and therapeutic use based on the main findings from in vitro cell lines models and in vivo research including animal experimental models and clinical trials. The chemistry, pharmacokinetics, toxicity, and safety of apigenin are also discussed. Perspectives on the apigenin research are outlined.
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Aprotosoaie, A.C., Miron, A. (2023). Apigenin: Chemistry and Pharmacology. In: Xiao, J. (eds) Handbook of Dietary Flavonoids. Springer, Cham. https://doi.org/10.1007/978-3-030-94753-8_2-1
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