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Galangin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology

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Handbook of Dietary Flavonoids

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Abstract

Galangin (GA) is a polyphenolic compound that belongs to the category of flavanol. This chapter deals with the biosynthesis, biotransformation, pharmacokinetics, pharmacology, and mechanism of action of galangin studied in various in vitro and in vivo models. It is well reported that galangin gets oxidized to kaempferol; however, GA is metabolized preferentially by glucuronide conjugation rather than sulfation and oxidation reactions. GA is extensively reported for its anticancer activity with different mechanisms of action. Next to that GA is a well-reported anti-inflammatory and antioxidant agent. It was also reported to show other activities like antidiabetic, chemoprotective, antiarthritic, enzyme-modulating, and immunomodulatory. There is much more needs on extensive studies to be performed to prove the efficacy of galangin as anticancer, anti-inflammatory, and antioxidant agents in human volunteers and to ensure its safety and efficacy in human system.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, University College of Engineering, Bharathidasan Institute of Technology Campus, Anna University, Tiruchirappalli, Tamil Nadu, India

    Sanmuga Priya Ekambaram, Senthamil Selvan Perumal & Sivasakthi Paramasivam

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  1. Sanmuga Priya Ekambaram
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  2. Senthamil Selvan Perumal
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  3. Sivasakthi Paramasivam
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Correspondence to Sanmuga Priya Ekambaram .

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  1. Department of Analytical Chemistry and Food Science, Universidade de Vigo, Vigo, Spain

    Jianbo Xiao

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Ekambaram, S.P., Perumal, S.S., Paramasivam, S. (2023). Galangin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology. In: Xiao, J. (eds) Handbook of Dietary Flavonoids. Springer, Cham. https://doi.org/10.1007/978-3-030-94753-8_10-1

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