Synonyms
Definition
The Baker-Lonsdale model describes the drug release from spherical monolithic drug delivery devices, in which the active pharmaceutical ingredient is initially dispersed throughout an inert diffusion matrix. It was derived from prior work by Higuchi on finely dispersed drug particles in an ointment base (in fact, it has been referred by some authors as Higuchi, Baker, and Lonsdale model). Higuchi originally assumed a flat geometry (thin film, slab); however, he later adapted his model to spherical geometries, in a similar manner that Baker and Lonsdale did.
In principle, the Baker-Lonsdale model is applied to homogeneous polymeric matrix systems (with no pores, fractures, or capillaries), through which transport occurs by dissolution of the permeating species in the polymer, and subsequent diffusion down a concentration gradient. In essence, the release kinetics are estimated by solving Fick’s laws with the appropriate boundary...
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bellera CL, Enrique AV, Talevi A, Bruno-Blanch LE. Advances in applications of nanotechnology to drug delivery: a biopharmaceutical perspective. In: Mercader AG, Castro EA, Haghi AK, editors. Nanoscience and computational chemistry: research progress. New York: Apple Academic Press; 2013. p. 1–24.
Scioli Montoto S, Muraca G, Ruiz ME. Solid lipid nanoparticles for drug delivery: pharmacological and biopharmaceutical aspects. Front Mol Biosci. 2020;7:319.
USP42 <1151> Pharmaceutical dosage forms. United States Pharmacopeia; 2019.
British Pharmacopoeia Commission. The British pharmacopoeia. London: British Pharmacopoeia Commission; 2008.
Sivasankaran S, Jonnalagadda S. Advances in controlled release hormonal technologies for contraception: a review of existing devices, underlying mechanisms, and future directions. J Control Release. 2021;330:797–811.
Baker RW, Sanders LM. Controlled release delivery systems. In: Synthetic membranes: science, engineering and applications. Dordrecht: Springer Netherlands; 1986. p. 581–624.
Baker RW, Lonsdale HK. Controlled release: mechanisms and rates. In: Tanquary AC, Lacey RE, editors. Controlled release of biologically active agents. New York: Plenum Press; 1975. p. 15–72.
Higuchi T. Rate of release of medicaments from ointment bases containing drugs in suspension. J Pharm Sci. 1961;50:874–5.
Lee PI. Modeling of drug release from matrix systems involving moving boundaries: approximate analytical solutions. Int J Pharm. 2011;418:18–27.
Siepmann J, Peppas NA. Higuchi equation: derivation, applications, use and misuse. Int J Pharm. 2011;418:6–12.
Roseman TJ, Higuchi WI. Release of medroxyprogesterone acetate from a silicone polymer. J Pharm Sci. 1970;59:353–7.
Higuchi T. Mechanism of sustained-action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices. J Pharm Sci. 1963;52:1145–9.
Costa P. An alternative method to the evaluation of similarity factor in dissolution testing. Int J Pharm. 2001;220:77–83.
Costa P, Sousa Lobo JM. Modeling and comparison of dissolution profiles. Eur J Pharm Sci. 2001;13:123–33.
Paul DR, McSpadden SK. Diffusional release of a solute from a polymer matrix. J Membr Sci. 1976;1:33–48.
Lapidus H, Lordi NG. Some factors affecting the release of a water-soluble drug from a compressed hydrophilic matrix. J Pharm Sci. 1966;55:840–3.
Lapidus H, Lordi NG. Drug release from compressed hydrophilic matrices. J Pharm Sci. 1968;57:1292–301.
Seki T, Kawaguchi T, Endoh H, Ishikawa K, Juni K, Nakano M. Controlled release of 3′, 5′-diester prodrugs of 5-fluoro-2′-deoxyuridine from poly-L-lactic acid microspheres. J Pharm Sci. 1990;79:985–7.
Desai SJ, Singh P, Simonelli AP, Higuchi WI. Investigation of factors influencing release of solid drug dispersed in inert matrices II quantitation of procedures. J Pharm Sci. 1966;55:1224–9.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Section Editor information
Rights and permissions
Copyright information
© 2022 Springer Nature Switzerland AG
About this entry
Cite this entry
Talevi, A., Ruiz, M.E. (2022). Baker-Lonsdale Model of Drug Release. In: Talevi, A. (eds) The ADME Encyclopedia. Springer, Cham. https://doi.org/10.1007/978-3-030-84860-6_37
Download citation
DOI: https://doi.org/10.1007/978-3-030-84860-6_37
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-84859-0
Online ISBN: 978-3-030-84860-6
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences