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Transdermal Drug Delivery

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The ADME Encyclopedia

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Synonyms

Emplastra transcutanea; Self-adhering transdermal drug delivery systems (TDS); Transdermal patches

Definition

The European Pharmacopoeia and the United States Pharmacopeia share similar definitions of transdermal delivery systems (TDS) which are presented as follows, respectively:

  • TDS are flexible pharmaceutical preparations of varying sizes, containing one or more active substances. They are intended to be applied to the unbroken skin in order to deliver the active substance(s) to the systemic circulation after passing through the skin barrier [1].

  • TDS are placed onto intact skin to deliver the drug to the systemic circulation. They are designed for prolonged release (up to 7 days) [2].

Historical Development

Topical remedies applied to the skin have been used since the origin of man, in most ancient cultures. References of medicated plasters (emplastra) can be found in ancient China (around 2000 BC). These early plasters generally contained multiple ingredients of herbal...

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References

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Author information

Authors and Affiliations

  1. Departamento de Tecnología Farmacéutica, Cátedra de Tecnología Farmacéutica II, Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina

    Marcelo Carlos Nacucchio

  2. Cátedra de Tecnología Farmacéutica II, Departamento de Tecnología Farmacéutica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina

    Héctor Juan Prado

  3. Instituto de Tecnología de Alimentos y Procesos Químicos (ITAPROQ), CONICET - Universidad de Buenos Aires, Buenos Aires, Argentina

    Héctor Juan Prado

Authors
  1. Marcelo Carlos Nacucchio
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  2. Héctor Juan Prado
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Editor information

Editors and Affiliations

  1. University of La Plata (UNLP), Argentinian National Council of Scientific and Technical Research (CONICET), La Plata, Argentina

    Alan Talevi

Section Editor information

  1. Quality Control of Pharmaceutical Products, National University of La Plata, La Plata, Argentina

    María Esperanza Ruiz

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Nacucchio, M.C., Prado, H.J. (2022). Transdermal Drug Delivery. In: Talevi, A. (eds) The ADME Encyclopedia. Springer, Cham. https://doi.org/10.1007/978-3-030-84860-6_16

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