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Microbial Production of Pantothenic Acid

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Microbial Production of Food Bioactive Compounds

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Abstract

Sustainable biosynthesis of value-added chemicals has been gaining interest in the last two decades due to increased environmental concerns and the depletion of petroleum resources. Metabolic engineering of microorganisms has been recognized as a significant development in making such bio-based production economical at a large scale to produce chemicals, fuels, amino acids, vitamins, polymers, and many others. D-pantothenic acid (DPA) encompasses many applications in the food, cosmetic, and pharmaceutical industries. Chemical, chemo-enzymatic, and biological routes were reported for the production of DPA. High-yielding chemical and chemo-enzymatic methods of DPA synthesis are limited by using poisonous chemicals and DL-pantolactone racemic mixture formation. Alternatively, the safe microbial fermentative route of DPA production was found promising. In this chapter, we have summarized the various metabolic engineering strategies and microbial systems reported for the microbial production of DPA.

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Abbreviations

ADC:

Aspartate-1-decarboxylase

ASP:

L-aspartic acid

AspA:

Aspartate ammonia-lyase

AspB:

Aspartate aminotransferase

aspB :

Gene encoding for aspartate aminotransferase

BA:

β-alanine

CH2-THF:

5,10-methylenetetrahydrofolate

CoA:

Coenzyme A

DPA:

D-pantothenic acid

DPL:

D-pantolactone

FA:

Fumaric acid

OD:

Optical density

panC :

Gene encoding for pantoate-β-alanine ligase

panD :

Gene encoding for aspartate-1-decarboxylase

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Authors and Affiliations

  1. BioPAT Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, India

    Subbi Rami Reddy Tadi, Ganesh Nehru & Senthilkumar Sivaprakasam

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  1. Subbi Rami Reddy Tadi
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  2. Ganesh Nehru
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  3. Senthilkumar Sivaprakasam
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Correspondence to Senthilkumar Sivaprakasam .

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Editors and Affiliations

  1. Iberian Agri-Food Center, University of Vigo, Vigo, Spain

    Seid Mahdi Jafari

  2. Department of Microbiology, Alzahra University, Tehran, Iran

    Farshad Darvishi Harzevili

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Tadi, S.R.R., Nehru, G., Sivaprakasam, S. (2022). Microbial Production of Pantothenic Acid. In: Jafari, S.M., Harzevili, F.D. (eds) Microbial Production of Food Bioactive Compounds. Springer, Cham. https://doi.org/10.1007/978-3-030-81403-8_6-1

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  • DOI: https://doi.org/10.1007/978-3-030-81403-8_6-1

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