Abstract
Colorectal cancer is the third most commonly diagnosed cancer worldwide and the second leading cause of death among all malignancies. Despite advances in colorectal cancer screening, the number of deaths has increased. Given that the incidence of colorectal cancer increases with age, it’s important to tailor treatment to this population with special needs. Here we discuss how to incorporate frailty, rather than age, to assess perioperative outcomes. To this end, several useful scoring systems that can easily be incorporated into general practice have been developed. In addition, chemotherapy risk calculators such as CARG or G8 can help predict the likelihood of chemotherapy toxicity in older patients. Focused geriatric assessment in patients with colorectal cancer is associated with improved outcomes such as a decrease in the incidence of chemotherapy toxicity and decreased risk of falls. Overall, geriatricians are an important part of the oncological treatment course and can advocate for their patients to receive tailored treatments to their functional status rather than their age alone.
References
Douaiher J, et al. Colorectal cancer-global burden, trends, and geographical variations. J Surg Oncol. 2017;115(5):619–30.
Bray F, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.
Silva A, et al. Impact of adiposity on staging and prognosis of colorectal cancer. Crit Rev Oncol Hematol. 2020;145:102857.
Siegel RL, et al. Colorectal cancer statistics, 2020. CA Cancer J Clin. 2020;70(3):145–64.
Henderson RH, et al. The economic burden of colorectal cancer across Europe: a population-based cost-of-illness study. Lancet Gastroenterol Hepatol. 2021;6(9):709–22.
Chen CT, et al. Medicare spending for breast, prostate, lung, and colorectal cancer patients in the year of diagnosis and year of death. Health Serv Res. 2018;53(4):2118–32.
Wilson LE, et al. Rapid rise in the cost of targeted cancer therapies for Medicare patients with solid tumors from 2006 to 2015. J Geriatr Oncol. 2021;12(3):375–80.
Reyes C, et al. Cost of disease progression in patients with metastatic breast, lung, and colorectal cancer. Oncologist. 2019;24(9):1209–18.
Wong MCS, et al. Differences in incidence and mortality trends of colorectal cancer worldwide based on sex, age, and anatomic location. Clin Gastroenterol Hepatol. 2021;19(5):955–966.e61.
Baijal P, Periyakoil V. Understanding frailty in cancer patients. Cancer J. 2014;20(5):358–66.
Collard RM, et al. Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc. 2012;60(8):1487–92.
de’Angelis N, et al. Surgical and regional treatments for colorectal cancer metastases in older patients: a systematic review and meta-analysis. PLoS One. 2020;15(4):e0230914.
Booth CM, et al. Management and outcome of colorectal cancer liver metastases in elderly patients: a population-based study. JAMA Oncol. 2015;1(8):1111–9.
Martínez-Cecilia D, Cipriani F, Vishal S, Ratti F, Tranchart H, Barkhatov L, … Hilal MA. Laparoscopic versus open liver resection for colorectal metastases in elderly and octogenarian patients: a multicenter propensity score based analysis of short-and long-term outcomes. Ann Surg. 2017;265(6):1192–200.
Mehta HB, Hughes BD, Sieloff E, Sura SO, Shan Y, Adhikari D, Senagore A. Outcomes of laparoscopic colectomy in younger and older patients: an analysis of nationwide readmission database. J Laparoendosc Adv Surg Tech. 2018;28(4):370–8.
Shahrokni A, Alexander K. The age of talking about age alone is over. Ann Surg Oncol. 2019;26:12–4.
Korc-Grodzicki B, Holmes HM, Shahrokni A. Geriatric assessment for oncologists. Cancer Biol Med. 2015;12(4):261–74.
Borson S, et al. The Mini-Cog as a screen for dementia: validation in a population-based sample. J Am Geriatr Soc. 2003;51(10):1451–4.
Creavin ST, et al. Mini-Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations. Cochrane Database Syst Rev. 2016;2016(1):CD011145.
Hamaker ME, Wildes TM, Rostoft S. Time to stop saying geriatric assessment is too time consuming. J Clin Oncol. 2017;35(25):2871–4.
Kristjansson SR, et al. Comprehensive geriatric assessment can predict complications in elderly patients after elective surgery for colorectal cancer: a prospective observational cohort study. Crit Rev Oncol Hematol. 2010;76(3):208–17.
Kristjansson SR, et al. Which elements of a comprehensive geriatric assessment (CGA) predict post-operative complications and early mortality after colorectal cancer surgery? J Geriatr Oncol. 2010;1(2):57–65.
Lee YH, et al. Use of a comprehensive geriatric assessment to predict short-term postoperative outcome in elderly patients with colorectal cancer. Ann Coloproctol. 2016;32(5):161.
Shahrokni A, et al. Geriatric assessment, not ASA physical status, is associated with 6-month postoperative survival in patients with cancer aged≥ 75 years. J Natl Compr Cancer Netw. 2019;17(6):687–94.
Decoster L, et al. Relevance of geriatric assessment in older patients with colorectal cancer. Clin Colorectal Cancer. 2017;16(3):e221–9.
Xue D-D, et al. Comprehensive geriatric assessment prediction of postoperative complications in gastrointestinal cancer patients: a meta-analysis. Clin Interv Aging. 2018;13:723–36.
Chen X, Mao G, Leng SX. Frailty syndrome: an overview. Clin Interv Aging. 2014;9:433–41.
Fried LP, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.
Rønning B, et al. Frailty indicators and functional status in older patients after colorectal cancer surgery. J Geriatr Oncol. 2014;5(1):26–32.
Michaud Maturana M, et al. The impact of frailty on clinical outcomes in colorectal cancer surgery: a systematic literature review. ANZ J Surg. 2021;91(11):2322–9.
Rockwood K, Mitnitski A. Frailty defined by deficit accumulation and geriatric medicine defined by frailty. Clin Geriatr Med. 2011;27(1):17–26.
Cohen HJ, et al. Frailty as determined by a comprehensive geriatric assessment-derived deficit-accumulation index in older patients with cancer who receive chemotherapy. Cancer. 2016;122(24):3865–72.
de Vries J, et al. Association of deficits identified by geriatric assessment with deterioration of health-related quality of life in patients treated for head and neck cancer. JAMA Otolaryngol Head Neck Surg. 2021;147(12):1089–99.
Kenig J, et al. Cumulative deficit model of geriatric assessment to predict the postoperative outcomes of older patients with solid abdominal cancer. J Geriatr Oncol. 2015;6(5):370–9.
Clough-Gorr KM, et al. Older breast cancer survivors: geriatric assessment domains are associated with poor tolerance of treatment adverse effects and predict mortality over 7 years of follow-up. J Clin Oncol. 2010;28(3):380–6.
Hamaker ME, et al. Baseline comprehensive geriatric assessment is associated with toxicity and survival in elderly metastatic breast cancer patients receiving single-agent chemotherapy: results from the OMEGA study of the Dutch breast cancer trialists’ group. Breast. 2014;23(1):81–7.
Antonio M, et al. Geriatric assessment predicts survival and competing mortality in elderly patients with early colorectal cancer: can it help in adjuvant therapy decision-making? Oncologist. 2017;22(8):934–43.
Shahrokni A, et al. Electronic rapid fitness assessment: a novel tool for preoperative evaluation of the geriatric oncology patient. J Natl Compr Cancer Netw. 2017;15(2):172–9.
Hurria A, et al. Reliability, validity, and feasibility of a computer-based geriatric assessment for older adults with cancer. J Oncol Pract. 2016;12(12):e1025–34.
McCleary NJ, et al. Feasibility of computer-based self-administered cancer-specific geriatric assessment in older patients with gastrointestinal malignancy. Oncologist. 2013;18(1):64–72.
Guerard E, et al. Electronic geriatric assessment: is it feasible in a multi-institutional study that included a notable proportion of older African American patients? (Alliance A171603). JCO Clin Cancer Inform. 2021;5:435–41.
Cuadra A, et al. The association between perioperative frailty and ability to complete a web-based geriatric assessment among older adults with cancer. Eur J Surg Oncol. 2023;49(3):662–6.
Cuadra A, et al. Introducing the v-RFA, a voice assistant-based geriatric assessment. J Geriatr Oncol. 2022;13(8):1253–5.
Hurria A, et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol. 2011;29(25):3457–65.
Hurria A, et al. Validation of a prediction tool for chemotherapy toxicity in older adults with cancer. J Clin Oncol. 2016;34(20):2366–71.
Ostwal V, et al. Cancer aging research group (CARG) score in older adults undergoing curative intent chemotherapy: a prospective cohort study. BMJ Open. 2021;11(6):e047376.
Bellera C, et al. Screening older cancer patients: first evaluation of the G-8 geriatric screening tool. Ann Oncol. 2012;23(8):2166–72.
van Walree IC, et al. A systematic review on the association of the G8 with geriatric assessment, prognosis and course of treatment in older patients with cancer. J Geriatr Oncol. 2019;10(6):847–58.
Marcucci M, et al. Interventions to prevent, delay or reverse frailty in older people: a journey towards clinical guidelines. BMC Med. 2019;17(1):193.
Cesari M, et al. The geriatric management of frailty as paradigm of “the end of the disease era”. Eur J Intern Med. 2016;31:11–4.
Mohile SG, et al. Practical assessment and management of vulnerabilities in older patients receiving chemotherapy: ASCO guideline for geriatric oncology. J Clin Oncol. 2018;36(22):2326–47.
Mohile SG, et al. Evaluation of geriatric assessment and management on the toxic effects of cancer treatment (GAP70+): a cluster-randomised study. Lancet. 2021;398(10314):1894–904.
Montroni I, et al. Surgical considerations for older adults with cancer: a multidimensional, multiphase pathway to improve care. J Clin Oncol. 2021;39(19):2090–101.
Hijazi Y, Gondal U, Aziz O. A systematic review of prehabilitation programs in abdominal cancer surgery. Int J Surg. 2017;39:156–62.
Briggs LG, et al. Prehabilitation exercise before urologic cancer surgery: a systematic and interdisciplinary review. Eur Urol. 2022;81(2):157–67.
Trevino KM, et al. Is screening for psychosocial risk factors associated with mental health care in older adults with cancer undergoing surgery? Cancer. 2020;126(3):602–10.
Grigoryan KV, Javedan H, Rudolph JL. Orthogeriatric care models and outcomes in hip fracture patients: a systematic review and meta-analysis. J Orthop Trauma. 2014;28(3):e49–55.
Eamer G, et al. Comprehensive geriatric assessment for older people admitted to a surgical service. Cochrane Database Syst Rev. 2018;1(1):CD012485.
Van Heghe A, et al. Effects of Orthogeriatric care models on outcomes of hip fracture patients: a systematic review and meta-analysis. Calcif Tissue Int. 2022;110(2):162–84.
Filippova OT, et al. Geriatric co-management leads to safely performed cytoreductive surgery in older women with advanced stage ovarian cancer treated at a tertiary care cancer center. Gynecol Oncol. 2019;154(1):77–82.
Shahrokni A, et al. Association of Geriatric comanagement and 90-day postoperative mortality among patients aged 75 years and older with cancer. JAMA Netw Open. 2020;3(8):e209265.
McMillan S, et al. Association of frailty with 90-day postoperative mortality & geriatric comanagement among older adults with cancer. Eur J Surg Oncol. 2022;48(4):903–8.
Giannotti C, et al. Effect of geriatric comanagement in older patients undergoing surgery for gastrointestinal cancer: a retrospective, before-and-after study. J Am Med Dir Assoc. 2022;23(11):1868.e9–1868.e16.
Letica-Kriegel AS, et al. Feasibility of a geriatric comanagement (GERICO) pilot program for patients 75 and older undergoing radical cystectomy. Eur J Surg Oncol. 2022;48(6):1427–32.
Cooper L, et al. Launching a geriatric surgery center: recommendations from the Society for Perioperative Assessment and Quality Improvement. J Am Geriatr Soc. 2020;68(9):1941–6.
Raphael MJ, et al. Neurotoxicity outcomes in a population-based cohort of elderly patients treated with adjuvant oxaliplatin for colorectal cancer. Clin Colorectal Cancer. 2017;16(4):397–404. e1
Tournigand C, et al. Adjuvant therapy with fluorouracil and oxaliplatin in stage II and elderly patients (between ages 70 and 75 years) with colon cancer: subgroup analyses of the Multicenter International Study of Oxaliplatin, Fluorouracil, and Leucovorin in the Adjuvant Treatment of Colon Cancer trial. J Clin Oncol. 2012;30(27):3353–60.
Grothey A, et al. Duration of adjuvant chemotherapy for stage III colon cancer. N Engl J Med. 2018;378(13):1177–88.
Jin J, et al. Multicenter, randomized, phase III trial of short-term radiotherapy plus chemotherapy versus long-term chemoradiotherapy in locally advanced rectal cancer (STELLAR). J Clin Oncol. 2022;40(15):1681.
O’Brien TN, Shahrokni A, Horgan AM. Total neoadjuvant therapy for rectal cancer: totally not translatable to the older patient? J Geriatr Oncol. 2023;14(1):101348.
Cercek A, et al. PD-1 blockade in mismatch repair–deficient, locally advanced rectal cancer. N Engl J Med. 2022;386(25):2363–76.
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Shahrokni, A., Pozdniakova, H., Nightingale, B. (2024). Colorectal Cancer in Older Adults. In: Wasserman, M.R., Bakerjian, D., Linnebur, S., Brangman, S., Cesari, M., Rosen, S. (eds) Geriatric Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-74720-6_78
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DOI: https://doi.org/10.1007/978-3-030-74720-6_78
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