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Colorectal Cancer in Older Adults

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Geriatric Medicine

Abstract

Colorectal cancer is the third most commonly diagnosed cancer worldwide and the second leading cause of death among all malignancies. Despite advances in colorectal cancer screening, the number of deaths has increased. Given that the incidence of colorectal cancer increases with age, it’s important to tailor treatment to this population with special needs. Here we discuss how to incorporate frailty, rather than age, to assess perioperative outcomes. To this end, several useful scoring systems that can easily be incorporated into general practice have been developed. In addition, chemotherapy risk calculators such as CARG or G8 can help predict the likelihood of chemotherapy toxicity in older patients. Focused geriatric assessment in patients with colorectal cancer is associated with improved outcomes such as a decrease in the incidence of chemotherapy toxicity and decreased risk of falls. Overall, geriatricians are an important part of the oncological treatment course and can advocate for their patients to receive tailored treatments to their functional status rather than their age alone.

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References

  1. Douaiher J, et al. Colorectal cancer-global burden, trends, and geographical variations. J Surg Oncol. 2017;115(5):619–30.

    Article  PubMed  Google Scholar 

  2. Bray F, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.

    Article  PubMed  Google Scholar 

  3. Silva A, et al. Impact of adiposity on staging and prognosis of colorectal cancer. Crit Rev Oncol Hematol. 2020;145:102857.

    Article  PubMed  Google Scholar 

  4. Siegel RL, et al. Colorectal cancer statistics, 2020. CA Cancer J Clin. 2020;70(3):145–64.

    Article  PubMed  Google Scholar 

  5. Henderson RH, et al. The economic burden of colorectal cancer across Europe: a population-based cost-of-illness study. Lancet Gastroenterol Hepatol. 2021;6(9):709–22.

    Article  PubMed  Google Scholar 

  6. Chen CT, et al. Medicare spending for breast, prostate, lung, and colorectal cancer patients in the year of diagnosis and year of death. Health Serv Res. 2018;53(4):2118–32.

    Article  PubMed  Google Scholar 

  7. Wilson LE, et al. Rapid rise in the cost of targeted cancer therapies for Medicare patients with solid tumors from 2006 to 2015. J Geriatr Oncol. 2021;12(3):375–80.

    Article  CAS  PubMed  Google Scholar 

  8. Reyes C, et al. Cost of disease progression in patients with metastatic breast, lung, and colorectal cancer. Oncologist. 2019;24(9):1209–18.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Wong MCS, et al. Differences in incidence and mortality trends of colorectal cancer worldwide based on sex, age, and anatomic location. Clin Gastroenterol Hepatol. 2021;19(5):955–966.e61.

    Article  PubMed  Google Scholar 

  10. Baijal P, Periyakoil V. Understanding frailty in cancer patients. Cancer J. 2014;20(5):358–66.

    Article  PubMed  Google Scholar 

  11. Collard RM, et al. Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc. 2012;60(8):1487–92.

    Article  PubMed  Google Scholar 

  12. de’Angelis N, et al. Surgical and regional treatments for colorectal cancer metastases in older patients: a systematic review and meta-analysis. PLoS One. 2020;15(4):e0230914.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Booth CM, et al. Management and outcome of colorectal cancer liver metastases in elderly patients: a population-based study. JAMA Oncol. 2015;1(8):1111–9.

    Article  PubMed  Google Scholar 

  14. Martínez-Cecilia D, Cipriani F, Vishal S, Ratti F, Tranchart H, Barkhatov L, … Hilal MA. Laparoscopic versus open liver resection for colorectal metastases in elderly and octogenarian patients: a multicenter propensity score based analysis of short-and long-term outcomes. Ann Surg. 2017;265(6):1192–200.

    Google Scholar 

  15. Mehta HB, Hughes BD, Sieloff E, Sura SO, Shan Y, Adhikari D, Senagore A. Outcomes of laparoscopic colectomy in younger and older patients: an analysis of nationwide readmission database. J Laparoendosc Adv Surg Tech. 2018;28(4):370–8.

    Article  Google Scholar 

  16. Shahrokni A, Alexander K. The age of talking about age alone is over. Ann Surg Oncol. 2019;26:12–4.

    Article  PubMed  Google Scholar 

  17. Korc-Grodzicki B, Holmes HM, Shahrokni A. Geriatric assessment for oncologists. Cancer Biol Med. 2015;12(4):261–74.

    PubMed  PubMed Central  Google Scholar 

  18. Borson S, et al. The Mini-Cog as a screen for dementia: validation in a population-based sample. J Am Geriatr Soc. 2003;51(10):1451–4.

    Article  PubMed  Google Scholar 

  19. Creavin ST, et al. Mini-Mental State Examination (MMSE) for the detection of dementia in clinically unevaluated people aged 65 and over in community and primary care populations. Cochrane Database Syst Rev. 2016;2016(1):CD011145.

    PubMed  PubMed Central  Google Scholar 

  20. Hamaker ME, Wildes TM, Rostoft S. Time to stop saying geriatric assessment is too time consuming. J Clin Oncol. 2017;35(25):2871–4.

    Article  PubMed  Google Scholar 

  21. Kristjansson SR, et al. Comprehensive geriatric assessment can predict complications in elderly patients after elective surgery for colorectal cancer: a prospective observational cohort study. Crit Rev Oncol Hematol. 2010;76(3):208–17.

    Article  PubMed  Google Scholar 

  22. Kristjansson SR, et al. Which elements of a comprehensive geriatric assessment (CGA) predict post-operative complications and early mortality after colorectal cancer surgery? J Geriatr Oncol. 2010;1(2):57–65.

    Article  Google Scholar 

  23. Lee YH, et al. Use of a comprehensive geriatric assessment to predict short-term postoperative outcome in elderly patients with colorectal cancer. Ann Coloproctol. 2016;32(5):161.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Shahrokni A, et al. Geriatric assessment, not ASA physical status, is associated with 6-month postoperative survival in patients with cancer aged≥ 75 years. J Natl Compr Cancer Netw. 2019;17(6):687–94.

    Article  Google Scholar 

  25. Decoster L, et al. Relevance of geriatric assessment in older patients with colorectal cancer. Clin Colorectal Cancer. 2017;16(3):e221–9.

    Article  PubMed  Google Scholar 

  26. Xue D-D, et al. Comprehensive geriatric assessment prediction of postoperative complications in gastrointestinal cancer patients: a meta-analysis. Clin Interv Aging. 2018;13:723–36.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Chen X, Mao G, Leng SX. Frailty syndrome: an overview. Clin Interv Aging. 2014;9:433–41.

    PubMed  PubMed Central  Google Scholar 

  28. Fried LP, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56.

    Article  CAS  PubMed  Google Scholar 

  29. Rønning B, et al. Frailty indicators and functional status in older patients after colorectal cancer surgery. J Geriatr Oncol. 2014;5(1):26–32.

    Article  PubMed  Google Scholar 

  30. Michaud Maturana M, et al. The impact of frailty on clinical outcomes in colorectal cancer surgery: a systematic literature review. ANZ J Surg. 2021;91(11):2322–9.

    Article  PubMed  Google Scholar 

  31. Rockwood K, Mitnitski A. Frailty defined by deficit accumulation and geriatric medicine defined by frailty. Clin Geriatr Med. 2011;27(1):17–26.

    Article  PubMed  Google Scholar 

  32. Cohen HJ, et al. Frailty as determined by a comprehensive geriatric assessment-derived deficit-accumulation index in older patients with cancer who receive chemotherapy. Cancer. 2016;122(24):3865–72.

    Article  PubMed  Google Scholar 

  33. de Vries J, et al. Association of deficits identified by geriatric assessment with deterioration of health-related quality of life in patients treated for head and neck cancer. JAMA Otolaryngol Head Neck Surg. 2021;147(12):1089–99.

    Article  PubMed  Google Scholar 

  34. Kenig J, et al. Cumulative deficit model of geriatric assessment to predict the postoperative outcomes of older patients with solid abdominal cancer. J Geriatr Oncol. 2015;6(5):370–9.

    Article  PubMed  Google Scholar 

  35. Clough-Gorr KM, et al. Older breast cancer survivors: geriatric assessment domains are associated with poor tolerance of treatment adverse effects and predict mortality over 7 years of follow-up. J Clin Oncol. 2010;28(3):380–6.

    Article  PubMed  Google Scholar 

  36. Hamaker ME, et al. Baseline comprehensive geriatric assessment is associated with toxicity and survival in elderly metastatic breast cancer patients receiving single-agent chemotherapy: results from the OMEGA study of the Dutch breast cancer trialists’ group. Breast. 2014;23(1):81–7.

    Article  CAS  PubMed  Google Scholar 

  37. Antonio M, et al. Geriatric assessment predicts survival and competing mortality in elderly patients with early colorectal cancer: can it help in adjuvant therapy decision-making? Oncologist. 2017;22(8):934–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Shahrokni A, et al. Electronic rapid fitness assessment: a novel tool for preoperative evaluation of the geriatric oncology patient. J Natl Compr Cancer Netw. 2017;15(2):172–9.

    Article  Google Scholar 

  39. Hurria A, et al. Reliability, validity, and feasibility of a computer-based geriatric assessment for older adults with cancer. J Oncol Pract. 2016;12(12):e1025–34.

    Article  PubMed  PubMed Central  Google Scholar 

  40. McCleary NJ, et al. Feasibility of computer-based self-administered cancer-specific geriatric assessment in older patients with gastrointestinal malignancy. Oncologist. 2013;18(1):64–72.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Guerard E, et al. Electronic geriatric assessment: is it feasible in a multi-institutional study that included a notable proportion of older African American patients? (Alliance A171603). JCO Clin Cancer Inform. 2021;5:435–41.

    Article  PubMed  Google Scholar 

  42. Cuadra A, et al. The association between perioperative frailty and ability to complete a web-based geriatric assessment among older adults with cancer. Eur J Surg Oncol. 2023;49(3):662–6.

    Article  PubMed  Google Scholar 

  43. Cuadra A, et al. Introducing the v-RFA, a voice assistant-based geriatric assessment. J Geriatr Oncol. 2022;13(8):1253–5.

    Article  CAS  PubMed  Google Scholar 

  44. Hurria A, et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol. 2011;29(25):3457–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Hurria A, et al. Validation of a prediction tool for chemotherapy toxicity in older adults with cancer. J Clin Oncol. 2016;34(20):2366–71.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Ostwal V, et al. Cancer aging research group (CARG) score in older adults undergoing curative intent chemotherapy: a prospective cohort study. BMJ Open. 2021;11(6):e047376.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Bellera C, et al. Screening older cancer patients: first evaluation of the G-8 geriatric screening tool. Ann Oncol. 2012;23(8):2166–72.

    Article  CAS  PubMed  Google Scholar 

  48. van Walree IC, et al. A systematic review on the association of the G8 with geriatric assessment, prognosis and course of treatment in older patients with cancer. J Geriatr Oncol. 2019;10(6):847–58.

    Article  PubMed  Google Scholar 

  49. Marcucci M, et al. Interventions to prevent, delay or reverse frailty in older people: a journey towards clinical guidelines. BMC Med. 2019;17(1):193.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Cesari M, et al. The geriatric management of frailty as paradigm of “the end of the disease era”. Eur J Intern Med. 2016;31:11–4.

    Article  PubMed  Google Scholar 

  51. Mohile SG, et al. Practical assessment and management of vulnerabilities in older patients receiving chemotherapy: ASCO guideline for geriatric oncology. J Clin Oncol. 2018;36(22):2326–47.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Mohile SG, et al. Evaluation of geriatric assessment and management on the toxic effects of cancer treatment (GAP70+): a cluster-randomised study. Lancet. 2021;398(10314):1894–904.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Montroni I, et al. Surgical considerations for older adults with cancer: a multidimensional, multiphase pathway to improve care. J Clin Oncol. 2021;39(19):2090–101.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Hijazi Y, Gondal U, Aziz O. A systematic review of prehabilitation programs in abdominal cancer surgery. Int J Surg. 2017;39:156–62.

    Article  PubMed  Google Scholar 

  55. Briggs LG, et al. Prehabilitation exercise before urologic cancer surgery: a systematic and interdisciplinary review. Eur Urol. 2022;81(2):157–67.

    Article  PubMed  Google Scholar 

  56. Trevino KM, et al. Is screening for psychosocial risk factors associated with mental health care in older adults with cancer undergoing surgery? Cancer. 2020;126(3):602–10.

    Article  PubMed  Google Scholar 

  57. Grigoryan KV, Javedan H, Rudolph JL. Orthogeriatric care models and outcomes in hip fracture patients: a systematic review and meta-analysis. J Orthop Trauma. 2014;28(3):e49–55.

    Article  PubMed  PubMed Central  Google Scholar 

  58. Eamer G, et al. Comprehensive geriatric assessment for older people admitted to a surgical service. Cochrane Database Syst Rev. 2018;1(1):CD012485.

    PubMed  Google Scholar 

  59. Van Heghe A, et al. Effects of Orthogeriatric care models on outcomes of hip fracture patients: a systematic review and meta-analysis. Calcif Tissue Int. 2022;110(2):162–84.

    Article  PubMed  Google Scholar 

  60. Filippova OT, et al. Geriatric co-management leads to safely performed cytoreductive surgery in older women with advanced stage ovarian cancer treated at a tertiary care cancer center. Gynecol Oncol. 2019;154(1):77–82.

    Article  PubMed  PubMed Central  Google Scholar 

  61. Shahrokni A, et al. Association of Geriatric comanagement and 90-day postoperative mortality among patients aged 75 years and older with cancer. JAMA Netw Open. 2020;3(8):e209265.

    Article  PubMed  PubMed Central  Google Scholar 

  62. McMillan S, et al. Association of frailty with 90-day postoperative mortality & geriatric comanagement among older adults with cancer. Eur J Surg Oncol. 2022;48(4):903–8.

    Article  PubMed  Google Scholar 

  63. Giannotti C, et al. Effect of geriatric comanagement in older patients undergoing surgery for gastrointestinal cancer: a retrospective, before-and-after study. J Am Med Dir Assoc. 2022;23(11):1868.e9–1868.e16.

    Article  PubMed  Google Scholar 

  64. Letica-Kriegel AS, et al. Feasibility of a geriatric comanagement (GERICO) pilot program for patients 75 and older undergoing radical cystectomy. Eur J Surg Oncol. 2022;48(6):1427–32.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Cooper L, et al. Launching a geriatric surgery center: recommendations from the Society for Perioperative Assessment and Quality Improvement. J Am Geriatr Soc. 2020;68(9):1941–6.

    Article  PubMed  Google Scholar 

  66. Raphael MJ, et al. Neurotoxicity outcomes in a population-based cohort of elderly patients treated with adjuvant oxaliplatin for colorectal cancer. Clin Colorectal Cancer. 2017;16(4):397–404. e1

    Article  PubMed  Google Scholar 

  67. Tournigand C, et al. Adjuvant therapy with fluorouracil and oxaliplatin in stage II and elderly patients (between ages 70 and 75 years) with colon cancer: subgroup analyses of the Multicenter International Study of Oxaliplatin, Fluorouracil, and Leucovorin in the Adjuvant Treatment of Colon Cancer trial. J Clin Oncol. 2012;30(27):3353–60.

    Article  CAS  PubMed  Google Scholar 

  68. Grothey A, et al. Duration of adjuvant chemotherapy for stage III colon cancer. N Engl J Med. 2018;378(13):1177–88.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Jin J, et al. Multicenter, randomized, phase III trial of short-term radiotherapy plus chemotherapy versus long-term chemoradiotherapy in locally advanced rectal cancer (STELLAR). J Clin Oncol. 2022;40(15):1681.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. O’Brien TN, Shahrokni A, Horgan AM. Total neoadjuvant therapy for rectal cancer: totally not translatable to the older patient? J Geriatr Oncol. 2023;14(1):101348.

    Article  PubMed  Google Scholar 

  71. Cercek A, et al. PD-1 blockade in mismatch repair–deficient, locally advanced rectal cancer. N Engl J Med. 2022;386(25):2363–76.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Armin Shahrokni .

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Shahrokni, A., Pozdniakova, H., Nightingale, B. (2024). Colorectal Cancer in Older Adults. In: Wasserman, M.R., Bakerjian, D., Linnebur, S., Brangman, S., Cesari, M., Rosen, S. (eds) Geriatric Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-74720-6_78

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  • DOI: https://doi.org/10.1007/978-3-030-74720-6_78

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