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Thyroid Disorders in Older Adults

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Geriatric Medicine
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Abstract

Thyroid disorders are common in older adults and may range from subclinical disease to overt thyroid under-activity or over-activity. Subclinical disease is common and requires regular follow-up and an evidence-based approach to guide subsequent management, since clinical consequences may be significant. Practitioners should be diligent about ascertaining the specific diagnosis in frail older adults on thyroid supplementation or suppression treatment. Abnormal thyroid function tests should be interpreted in the context of the clinical scenario as well as current medication regimen. A high index of suspicion should be maintained for the presence of secondary thyroid disease due to pituitary dysfunction. The finding of nodular thyroid disease requires systematic measurement of thyroid function and appropriate imaging studies and biopsy if indicated and consistent with the patient’s care goals.

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References

  1. Ajish TP, Jayakumar RV. Geriatric thyroidology: an update. Indian J Endocrinol Metab. 2012;16(4):542–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Andersen S, Bruun NH, Pedersen KM, Laurberg P. Biologic variation is important for interpretation of thyroid function tests. Thyroid. 2003;13:1069–78. https://doi.org/10.1089/105072503770867237.

    Article  CAS  PubMed  Google Scholar 

  3. Antonopoulou M, Sharma R, Farag A, Banerji M, et al. Hypopituitarism in the elderly. Maturitas. 2012;72:277–85.

    Article  CAS  PubMed  Google Scholar 

  4. Baskin J, Cobin R, Duick D, Gharib H, et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism. Endocr Pract. 2002;8(6):457–69.

    Article  PubMed  Google Scholar 

  5. Belchetz PE. Idiopathic hypopituitarism in the elderly. BMJ. 1985;291:247–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Bemben DA, Hamm RM, Morgan L, Winn P, et al. Thyroid disease in the elderly. Part 2. Predictability of subclinical hypothyroidism. J Fam Pract. 1994;38(6):583.

    CAS  PubMed  Google Scholar 

  7. Biondi B, Cappola A, Cooper D. Subclinical hypothyroidism: a review. JAMA. 2019;322(2):153.

    Article  CAS  PubMed  Google Scholar 

  8. Cappola A. The thyrotropin reference range should be changed in older patients. JAMA. 2019;322:1961–2. https://doi.org/10.1001/jama.2019.14728. Online ahead of print.

    Article  PubMed  Google Scholar 

  9. Chaker L, Baumgartner C, den Elzen W, Ikram M, et al. Subclinical hypothyroidism and the risk of stroke events and fatal stroke: an individual participant data analysis. J Clin Endocrinol Metab. 2015;100(6):2181.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Chu J, Crapo L. The treatment of subclinical hypothyroidism is seldom necessary. J Clin Endocrinol Metab. 2001;86(10):4591.

    Article  CAS  PubMed  Google Scholar 

  11. Davies JS, Scanlon MF. Hypopituitarism after coronary artery bypass grafting. BMJ. 1998;316:682–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. DeLuise MA. Thyroid disease in the elderly. J Pharm Pract Res. 2003;33:228–30.

    Article  Google Scholar 

  13. Donangelo I, Young S. Subclinical hyperthyroidism: when to consider treatment. Am Fam Physician. 2017;95(11):710–6.

    PubMed  Google Scholar 

  14. Faggiano A, Del Prete M, Marciello F, Marotta V, et al. Thyroid diseases in the elderly. Minerva Endocrinol. 2011;36:211–31.

    CAS  PubMed  Google Scholar 

  15. Garber JR, Cobin RH, Gharib H, Pessah-Pollack R, Singer PA, Woeber KA, ATA/AACE Guidelines. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocr Pract. 2012a;18(6):988–1028. https://doi.org/10.4158/EP12280.GL.

    Article  PubMed  Google Scholar 

  16. Garber J, Cobin R, Gharib H, Hennessey J, et al. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Thyroid. 2012b;22(12):1200.

    Article  CAS  PubMed  Google Scholar 

  17. Gharib H, Tuttle R, Baskin H, Fish L. Subclinical thyroid dysfunction: a joint statement on management from the American Association of Clinical Endocrinologists, the American Thyroid Association, and the Endocrine Society. J Clin Endocrinol Metab. 2005;90(1):581.

    Article  CAS  PubMed  Google Scholar 

  18. Gibbons V, Lawrenson R, Sleigh P, Yarndley T, et al. Investigating the pathways in primary practice leading to the diagnosis of central hypothyroidism. NZMJ. 2012;125:83–90.

    Google Scholar 

  19. Goldberg P, Inzucchi S. Critical issues in endocrinology. Clin Chest Med. 2003;24:583–606.

    Article  PubMed  Google Scholar 

  20. Harjai K, Licata A. Effects of amiodarone on thyroid function. Ann Intern Med. 1997;126:63–73.

    Article  CAS  PubMed  Google Scholar 

  21. Johnston S, Hoult S, Chan C. Falling again. Lancet. 1997;349:26–8.

    Article  CAS  PubMed  Google Scholar 

  22. Kramer C, von Muhlen D, Kritz-Silverstein D, Barrett-Connor E. Treated hypothyroidism, cognitive function, and depressed mood in old age: the Rancho Bernardo Study. Eur J Endocrinol. 2009;161:917–21.

    Article  CAS  PubMed  Google Scholar 

  23. Mariotti S, et al. The aging thyroid. Endocr Rev. 1995;16:686–715.

    Article  CAS  PubMed  Google Scholar 

  24. Martin F, Deam D. Hyperthyroidism in elderly hospitalized patients. Med J Aust. 1996;164:200–3.

    Article  CAS  PubMed  Google Scholar 

  25. Mazzoccoli G, et al. Hypothalamus-hypophysis-thyroid axis function in healthy aging. J Biol Regul Homeost Agents. 2010;24(4):433–9.

    CAS  PubMed  Google Scholar 

  26. Mitrou P, Raptis S, Dimitriadis G. Thyroid disease in older people. Maturitas. 2011;70:5–9.

    Article  PubMed  Google Scholar 

  27. Moon S, Kong SH, Choi HS, Hwangbo Y, et al. Relation of subclinical hypothyroidism is associated with cardiovascular events and all-cause mortality in adults with high cardiovascular risk. Am J Cardiol. 2018;122(4):571.

    Article  PubMed  Google Scholar 

  28. Narayana S, Woods D, Boos C. Management of amiodarone-related thyroid problems. Ther Adv Endocrinol Metab. 2011;2(3):115–26.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Ochs N, Auer R, Bauer D, Nanchen D, Gussekloo J, et al. Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality. Ann Intern Med. 2008;148:832–45.

    Article  PubMed  Google Scholar 

  30. Perry H. The endocrinology of aging. Clin Chem. 1999;45(8B):1369–76.

    Article  CAS  PubMed  Google Scholar 

  31. Piga M, Serra A, Boi F, Tanda ML, Martino E, Mariotti S. Amiodarone-induced thyrotoxicosis. A review. Minerva Endocrinol. 2008;33(3):213–28.

    CAS  PubMed  Google Scholar 

  32. Rhee C, Curhan G, Alexander E, Bhan I, et al. Subclinical hypothyroidism and survival: the effects of heart failure and race. J Clin Endocrinol Metab. 2013;98(6):2326–36.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Ross DS, Burch HB, Cooper DS, Greenlee MC, et al. American Thyroid Association guidelines for diagnosis and management of hyperthyroidism and other causes of thyrotoxicosis. Thyroid. 2016;26(10):1343.

    Article  PubMed  Google Scholar 

  34. Ruggeri RM, Trimarchi F, Biondi B. l-thyroxine replacement therapy in the frail elderly: a challenge in clinical practice. Eur J Endocrinol. 2017;177:R199–217.

    Article  CAS  PubMed  Google Scholar 

  35. Samuels MH, Schuff KG, Carlson NE, Carello P, et al. Health status, mood, and cognition in experimentally induced subclinical hypothyroidism. J Clin Endocrinol Metab. 2007;92(7):2545.

    Article  CAS  PubMed  Google Scholar 

  36. Solomen B, Glinoer D, Lagasse R, Wartofsky L. Current trends in management of graves’ disease. J Clin Endocrinol Metab. 1990;70:1518–24.

    Article  Google Scholar 

  37. Somwaru LL, Arnold AM, Joshi N, Fried LP, Cappola AR. High frequency of and factors associated with thyroid hormone over-replacement and under-replacement in men and women aged 65 and over. J Clin Endocrinol Metab. 2009;94(4):1342. Epub 2009 Jan 6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Tan Z, Beiser A, Vasan R, Au R, et al. Thyroid function and the risk of Alzheimer disease: the Framingham study. Arch Intern Med. 2008;168(14):1514.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Tognini S, et al. Non-thyroidal illness syndrome and short-term survival in a hospitalized older population. Age Aging. 2010;39:46–50.

    Article  Google Scholar 

  40. Trivalle C, Doucet J, Chassagne P, Landrin I, et al. Differences in the signs and symptoms of hyperthyroidism in older and younger patients. JAGS. 1996;44:50–3.

    Article  CAS  Google Scholar 

  41. Vanderpump MP, et al. The incidence of thyroid disorders in the community: a twenty-year follow-up of the Wickham survey. Clin Endocrinol. 1995;43:55–68.

    Article  CAS  Google Scholar 

  42. Veldhius JD. Altered pulsatile and coordinate secretion of pituitary hormones in aging: evidence of feedback disruption. Aging. 1997;9(4 Suppl):19–20.

    Google Scholar 

Epidemiology

  1. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA, et al. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and nutrition examination survey (NHANES III). J Clin Endocrinol Metab. 2002;87:489–99. https://doi.org/10.1210/jcem.87.2.8182.

    Article  CAS  PubMed  Google Scholar 

  2. Leng O, Razvi S. Hypothyroidism in the older population. Thyroid Res. 2019;12:2. https://doi.org/10.1186/s13044-019-0063-3.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Taylor PN, et al. Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol. 2018;14:301–16. https://doi.org/10.1038/nrendo.2018.18.

    Article  PubMed  Google Scholar 

Drugs and Thyroid Hormone Action

  1. Burch HB. Drug effects on the thyroid. N Engl J Med. 2019;381:749–61. https://doi.org/10.1056/NEJMra1901214.

    Article  CAS  PubMed  Google Scholar 

Thyroid Nodules and Thyroid Cancer

  1. Guerra A, Di Crescenzo V, Garzi A, Cinelli M, Carlomagno C, Pepe S, Zeppa P, Tonacchera M, Vitale M. Diagnostic utility of BRAF V600E mutation testing in thyroid nodules in elderly patients. BMC Surg. 2013;13:S37. http://bmcsurg.biomedcentral.com

    Article  PubMed  PubMed Central  Google Scholar 

  2. Gupta KL. Neoplasm of the thyroid gland. Clin Geriatr Med. 1995;11:271–90.

    Article  CAS  PubMed  Google Scholar 

  3. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L. 2015 American Thyroid Association Management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26(1):1.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Khadra H, Kholmatov R, Monlezun D, Kandil E. Do anticoagulation medications increase the risk of haematoma in ultrasound-guided fine needle aspiration of thyroid lesions? Cytopathology. 2018;29(6):565–8. https://doi.org/10.1111/cyt.12608. Epub 2018 Aug 3. PMID: 29969159.

    Article  PubMed  Google Scholar 

  5. Mazzaferri EL. Management of the solitary thyroid nodule. NEJM. 1993;328:553–9.

    Article  CAS  PubMed  Google Scholar 

  6. Nayar R, Ivanovic M. The indeterminate thyroid fine-needle aspiration: experience from an academic center using terminology similar to that proposed in the 2007 National Cancer Institute Thyroid fine needle aspiration state of the science conference. Cancer. 2009;117:195–202.

    PubMed  Google Scholar 

  7. Rossi ED, Bizzarro T, Martini M, Straccia P, Lombardi CP, Pontecorvi A, Larocca LM, Fadda G. The role of fine-needle aspiration in the thyroid nodules of elderly patients. Oncotarget. 2016;7(11):11850–9. https://doi.org/10.18632/oncotarget.7643.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Sherman SI. Thyroid carcinoma. Lancet. 2003;361(9356):501–11. https://doi.org/10.1016/S0140-6736(03)12488-9.

    Article  PubMed  Google Scholar 

  9. Sipos JA. Advances in ultrasound for the diagnosis and management of thyroid cancer. Thyroid. 2009;19(12):1363–72. https://doi.org/10.1089/thy.2009.1608. PMID: 20001718.

    Article  PubMed  Google Scholar 

  10. Sorrenti S, Baldini E, Tartaglia F, et al. Nodular thyroid disease in the elderly: novel molecular approaches for the diagnosis of malignancy. Aging Clin Exp Res. 2017;29:7–13. https://doi.org/10.1007/s40520-016-0654-y.

    Article  PubMed  Google Scholar 

Thyroid Surgery

  1. Marvin K, Parham K. Differentiated thyroid cancer in people aged 85 and older. J Am Geriatr Soc. 2015;63:932–7.

    Article  PubMed  Google Scholar 

  2. Raffaelli M, Bellantone R, Princi P, De Crea C, Rossi ED, Fadda G, Lombardi CP. Surgical treatment of thyroid diseases in elderly patients. Am J Surg. 2010;200:467–72.

    Article  PubMed  Google Scholar 

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Correspondence to Naushira Pandya .

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Pandya, N., Hames, E. (2024). Thyroid Disorders in Older Adults. In: Wasserman, M.R., Bakerjian, D., Linnebur, S., Brangman, S., Cesari, M., Rosen, S. (eds) Geriatric Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-74720-6_39

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  • DOI: https://doi.org/10.1007/978-3-030-74720-6_39

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