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Immunology of Ageing

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Geriatric Medicine

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Abstract

Immunity protects the host against infection, but becomes dysregulated with increasing age and can be a dangerous ally. Older adults tend to respond less well to infections but at the same time suffer more immunopathology. Better understanding of age-related changes to immunity will lead to more appropriate interventions to enhance protective immunity and at the same time reduce immunopathology. To this end, this chapter briefly overviews what is known about the processes leading to human immunosenescence, considering age-associated changes to innate and adaptive immunity and their clinical consequences.

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Authors and Affiliations

  1. Department of Immunology, University of Tübingen, Tübingen, Germany

    Graham Pawelec

  2. Health Sciences North Research Institute, Sudbury, ON, Canada

    Graham Pawelec

  3. Max Planck Institute for Human Development, Berlin, Germany

    Ludmila Müller

Authors
  1. Graham Pawelec
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  2. Ludmila Müller
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Corresponding author

Correspondence to Graham Pawelec .

Editor information

Editors and Affiliations

  1. California Association of Long Term Care Medicine, Newbury Park, CA, USA

    Michael R. Wasserman

  2. Betty Irene Moore School of Nursing, University of California, Davis, Sacramento, CA, USA

    Debra Bakerjian

  3. Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO, USA

    Sunny Linnebur

  4. Division of Geriatrics, SUNY Upstate Medical University, Syracuse, NY, USA

    Sharon Brangman

  5. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy

    Matteo Cesari

  6. Section of Geriatric Medicine, Division of Internal Medicine, Department of Medicine, Cedars-Sinai, Beverly Hills, CA, USA

    Sonja Rosen

Section Editor information

  1. California Association of Long Term Care Medicine, Newbury Park, California, USA

    Michael R. Wasserman M.D., CMD

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Pawelec, G., Müller, L. (2024). Immunology of Ageing. In: Wasserman, M.R., Bakerjian, D., Linnebur, S., Brangman, S., Cesari, M., Rosen, S. (eds) Geriatric Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-74720-6_104

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