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Safety of Intravenous and Inhalation Anesthetics

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Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

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Abstract

Here is presented, in chronological order, the studies that established the standards and determined the parameters currently considered for the safe use of anesthetic agents administered by intravenous or inhalation routes. The methods used in the experimental settings, as well as the modifications in the protocols to adapt to different clinical conditions, are described and discussed; The pharmacological criteria and the impact of these anesthetics on the cardiovascular and pulmonary systems are highlighted. However, additional information regarding the mechanisms of action of such agents is still needed, which would improve their use in terms of safety and efficacy.

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Author information

Authors and Affiliations

  1. Department of Anesthesiology, School of Medicine, University of Utah, Salt Lake City, UT, USA

    Luiz Fernando Ferrari

  2. Center for Neuroplasticity and Pain (CNAP), SMI, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark

    Lars Arendt-Nielsen

  3. Department of Medical Gastroenterology, Mech-Sense, Aalborg University Hospital, Aalborg, Denmark

    Lars Arendt-Nielsen

Authors
  1. Luiz Fernando Ferrari
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  2. Lars Arendt-Nielsen
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Correspondence to Luiz Fernando Ferrari .

Editor information

Editors and Affiliations

  1. CorDynamics, Dieburg, Hessen, Germany

    Franz J. Hock

  2. CorDynamics, Chicago, IL, USA

    Michael R. Gralinski

  3. Cytokinetics (United States), South San Francisco, CA, USA

    Michael K. Pugsley

Section Editor information

  1. Safety Pharm Consultant, Dieburg, Germany

    Franz J. Hock DSc

  2. CorDynamics, Inc., Chicago, IL, USA

    Michael R. Gralinski Ph.D

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Ferrari, L.F., Arendt-Nielsen, L. (2023). Safety of Intravenous and Inhalation Anesthetics. In: Hock, F.J., Gralinski, M.R., Pugsley, M.K. (eds) Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Springer, Cham. https://doi.org/10.1007/978-3-030-73317-9_68-1

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  • DOI: https://doi.org/10.1007/978-3-030-73317-9_68-1

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  • Print ISBN: 978-3-030-73317-9

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