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Hot Melt Extrusion and Complex Coacervation System for Delivering Nutraceuticals and Nanonutraceuticals

  • Living reference work entry
  • First Online:
Handbook of Nutraceuticals

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Abstract

Nutraceuticals or bioceuticals are termed as oral nutritional constituents considered to have a therapeutic or health benefit. Encapsulation technology has been used in pharmaceutical industry for drug delivery due to various reason, viz., improve bioactive delivery, packing solids, liquids, or gaseous materials in small capsules, lesser degradation of volatile compound, etc. Inside the body various factors can compromise the biologically availability of a compound such as lesser gastric residence time, stability, permeability is very low, and difficulty in gastrointestinal (GI) tract solubility. The delivery systems at various levels and micro- and nanoscale area have fascinated researchers worldwide. Nanocarriers are polymeric, lipid, carbon, metal, etc., based, which are potentially used as delivery tools for various drugs and management and treatment of diseases. Hot-melt extrusion and complex coacervation systems are techniques that are gaining its popularity in the field of nutraceutical industry and has various advantages over conventional processing techniques. Hot melt extrusion technology is successfully adopted for the preparation of solid molecular dispersion of active pharmaceutical ingredients (APIs) whereas in complex coacervation process separation between the insoluble complex coacervates and the liquid will happen due to electrostatic binding between oppositely charged polymers.

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Authors and Affiliations

  1. Department of Food Technology, Rajiv Gandhi University, Doimukh, Arunachal Pradesh, India

    Duyi Samyor

  2. Department of Food Engineering and Technology, Tezpur University, Tezpur, Assam, India

    Nemnunhoi Haokip

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  1. Duyi Samyor
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  2. Nemnunhoi Haokip
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Editors and Affiliations

  1. Mahatma Gandhi University, Kottayam, Kerala, India

    R. Rajakumari

  2. Mahatma Gandhi University, Kottayam, Kerala, India

    Sabu Thomas

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Samyor, D., Haokip, N. (2024). Hot Melt Extrusion and Complex Coacervation System for Delivering Nutraceuticals and Nanonutraceuticals. In: Rajakumari, R., Thomas, S. (eds) Handbook of Nutraceuticals. Springer, Cham. https://doi.org/10.1007/978-3-030-69677-1_43-1

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  • DOI: https://doi.org/10.1007/978-3-030-69677-1_43-1

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