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Anorexia Nervosa and Eye Movements

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Eating Disorders

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Abstract

Eye movement tasks have been used widely in psychiatric and neurological illnesses to gain a better understanding of cognitive processes and the neurobiology involved in these conditions. A range of different eye movement tasks have been employed, most of which have focused on saccadic eye movements – the fast, “jerky” eye movement humans typically use to view their surroundings. This chapter will provide an overview of the eye movement literature in anorexia nervosa (AN) to date and will describe the value of gaining a better understanding of eye movements to inform improved diagnosis, treatment, and prevention of AN.

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Abbreviations

AN:

Anorexia nervosa

BMI:

Body mass index

DLPFC:

Dorsolateral prefrontal cortex

FEF:

Frontal eye fields

GABA:

gamma-Aminobutyric acid

HC:

Healthy control

LIP:

Lateral intraparietal lobule

SD:

Standard deviation

SEF:

Supplementary eye fields

References

  • Abadi R, Gowen E (2004) Characteristics of saccadic intrusions. Vis Res 44:2675–2690

    Article  CAS  PubMed  Google Scholar 

  • Abadi RV, Clement R, Gowen E (2003) Levels of fixation. Levels of perception. Springer

    Google Scholar 

  • Abel LA (2009) Saccades in adult Niemann-Pick disease type C reflect frontal, brainstem, and biochemical deficits. Neurology 72:1083

    Article  CAS  PubMed  Google Scholar 

  • Abel LA, Douglas J (2007) Effects of age on latency and error generation in internally mediated saccades. Neurobiol Aging 28:627–637

    Article  PubMed  Google Scholar 

  • Abel LA, Unverzagt F, Yee RD (2002) Effects of stimulus predictability and interstimulus gap on saccades in Alzheimer’s disease. Dement Geriatr Cogn Disord 13:235–243

    Article  PubMed  Google Scholar 

  • Bahill AT, Adler D, Stark L (1975) Most naturally occurring human saccades have magnitudes of 15° or less. Invest Ophthalmol Vis Sci 14:468–469

    CAS  Google Scholar 

  • Bauer A, Schneider S, Waldorf M, Braks K, Huber TJ, Adolph D, Vocks S (2017a) Selective visual attention towards oneself and associated state body satisfaction: an eye-tracking study in adolescents with different types of eating disorders. J Abnorm Child Psychol 45:1647–1661

    Article  PubMed  Google Scholar 

  • Bauer A, Schneider S, Waldorf M, Cordes M, Huber TJ, Braks K, Vocks S (2017b) Visual processing of one’s own body over the course of time: evidence for the vigilance-avoidance theory in adolescents with anorexia nervosa? Int J Eat Disord 50:1205–1213

    Article  PubMed  Google Scholar 

  • Beauchamp MS, Petit L, Ellmore TM, Ingeholm J, Haxby JV (2001) A parametric fMRI study of overt and covert shifts of visuospatial attention. NeuroImage 14:310–321

    Article  CAS  PubMed  Google Scholar 

  • Beilharz F, Castle DJ, Phillipou A, Rossell SL (2018) Visual training program for body dysmorphic disorder: protocol for a novel intervention pilot and feasibility trial. Pilot Feasibility Stud 4:1–13

    Article  Google Scholar 

  • Blechert J, Ansorge U, Tuschen-Caffier B (2010) A body-related dot-probe task reveals distinct attentional patterns for bulimia nervosa and anorexia nervosa. J Abnorm Psychol 119:575–585

    Article  PubMed  Google Scholar 

  • Bowling AC, Hindman EA, Donnelly JF (2012) Prosaccade errors in the antisaccade task: differences between corrected and uncorrected errors and links to neuropsychological tests. Exp Brain Res 216:169–179

    Google Scholar 

  • Brown MRG, Goltz HC, Vilis T, Ford KA, Everling S (2006) Inhibition and generation of saccades: rapid event-related fMRI of prosaccades, antisaccades, and nogo trials. NeuroImage 33:644–659

    Article  PubMed  Google Scholar 

  • Bruce CJ, Goldberg ME, Bushnell MC, Stanton GB (1985) Primate frontal eye fields. II. Physiological and anatomical correlates of electrically evoked eye movements. J Neurophysiol 54:714–734

    Article  CAS  PubMed  Google Scholar 

  • Buttner U, Buttner-Ennever JA, Henn V (1977) Vertical eye movement related unit activity in the rostral mesencephalic reticular formation of the alert monkey. Brain Res 130:239–252

    Article  CAS  PubMed  Google Scholar 

  • Buttner-Ennever JA, Buttner U (1978) A cell group associated with vertical eye movements in the rostral mesencephalic reticular formation of the monkey. Brain Res 151:31–47

    Article  CAS  PubMed  Google Scholar 

  • Cipolli C, Sancini M, Tuozzi G, Bolzani R, Mutinelli P, Flamigni C, Porcu E (1989) Gaze and eye-contact with anorexic adolescents. Br J Med Psychol 62(Pt 4):365–369

    Article  PubMed  Google Scholar 

  • Clower DM, West RA, Lynch JC, Strick PL (2001) The inferior parietal lobule is the target of output from the superior colliculus, hippocampus, and cerebellum. J Neurosci 21:6283–6291

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Corbetta M, Akbudak E, Conturo TE, Snyder AZ, Ollinger JM, Drury HA, Linenweber MR, Petersen SE, Raichle ME, van Essen DC (1998) A common network of functional areas for attention and eye movements. Neuron 21:761–773

    Article  CAS  PubMed  Google Scholar 

  • Cornelissen KK, Cornelissen PL, Hancock PJ, Tovée MJ (2016) Fixation patterns, not clinical diagnosis, predict body size over-estimation in eating disordered women and healthy controls. Int J Eat Disord 49:507–518

    Article  PubMed  PubMed Central  Google Scholar 

  • Crawford TJ, Higham S, Renvoize T, Patel J, Dale M, Suriya A, Tetley S (2005) Inhibitory control of saccadic eye movements and cognitive impairment in Alzheimer’s disease. Biol Psychiatry 57:1052–1060

    Article  PubMed  Google Scholar 

  • Curtis CE, D’esposito M (2003) Success and failure suppressing reflexive behavior. J Cogn Neurosci 15:409–418

    Article  PubMed  Google Scholar 

  • Dinkler L, Rydberg Dobrescu S, Råstam M, Gillberg IC, Gillberg C, Wentz E, Hadjikhani N (2019) Visual scanning during emotion recognition in long-term recovered anorexia nervosa: an eye-tracking study. Int J Eat Disord 52:691–700

    Article  PubMed  Google Scholar 

  • Edwards SB, Ginsburgh CL, Henkel CK, Stein BE (1979) Sources of subcortical projections to the superior colliculus in the cat. J Comp Neurol 184:309–329

    Article  CAS  PubMed  Google Scholar 

  • Everling S, Fischer B (1998) The antisaccade: a review of basic research and clinical studies. Neuropsychologia 36:885–899

    Article  CAS  PubMed  Google Scholar 

  • Ford KA, Goltz HC, Brown MRG, Everling S (2005) Neural processes associated with antisaccade task performance investigated with event-related FMRI. J Neurophysiol 94:429

    Article  PubMed  Google Scholar 

  • Freeman R, Touyz S, Sara G, Rennie C, Gordon E, Beumont P (1991) In the eye of the beholder: processing body shape information in anorexic and bulimic patients. Int J Eat Disord 10:709–714

    Article  Google Scholar 

  • Fujiwara E, Kube VL, Rochman D, Macrae-Korobkov AK, Peynenburg V, Program UOAHED (2017) Visual attention to ambiguous emotional faces in eating disorders: role of alexithymia. Eur Eat Disord Rev 25:451–460

    Article  PubMed  Google Scholar 

  • George HR, Cornelissen PL, Hancock PJ, Kiviniemi VV, Tovée MJ (2011) Differences in eye-movement patterns between anorexic and control observers when judging body size and attractiveness. Br J Psychol 102:340–354

    Article  CAS  PubMed  Google Scholar 

  • Giel KE, Friederich HC, Teufel M, Hautzinger M, Enck P, Zipfel S (2011) Attentional processing of food pictures in individuals with anorexia nervosa–an eye-tracking study. Biol Psychiatry 69:661–667

    Article  PubMed  Google Scholar 

  • Giel KE, Kullmann S, Preißl H, Bischoff SC, Thiel A, Schmidt U, Zipfel S, Teufel M (2013) Understanding the reward system functioning in anorexia nervosa: crucial role of physical activity. Biol Psychol 94:575–581

    Article  PubMed  Google Scholar 

  • Giel KE, Conzelmann A, Renner TJ, Richter T, Martin Benito S, Zipfel S, Schag K (2020) Attention allocation to illness-compatible information discriminates women with active versus weight-recovered anorexia nervosa. Int J Eat Disord 53:1270–1279

    Article  PubMed  Google Scholar 

  • Gnadt JW (1991) Sensorimotor transformation during eye movements to remembered visual targets. Vis Res 31:693

    Article  CAS  PubMed  Google Scholar 

  • Godier LR, Scaife JC, Braeutigam S, Park RJ (2016) Enhanced early neuronal processing of food pictures in anorexia nervosa: a magnetoencephalography study. Psychiatry J 2016: 1795901

    Google Scholar 

  • Guitton D, Buchtel HA, Douglas RM (1985) Frontal lobe lesions in man cause difficulties in suppressing reflexive glances and in generating goal-directed saccades. Exp Brain Res 58:455–472

    Article  CAS  PubMed  Google Scholar 

  • Hallett PE (1978) Primary and secondary saccades to goals defined by instructions. Vis Res 18:1279–1296

    Article  CAS  PubMed  Google Scholar 

  • Hallett PE, Lightstone AD (1976) Saccadic eye movements to flashed targets. Vis Res 16:107–114

    Article  CAS  PubMed  Google Scholar 

  • Harrison A, Watterson SV, Bennett SD (2018) An experimental investigation into the use of eye-contact in social interactions in women in the acute and recovered stages of anorexia nervosa. Int J Eat Disord 52(1):61–70

    Article  Google Scholar 

  • Hartmann A, Borgers T, Thomas JJ, Giabbiconi CM, Vocks S (2020) Faced with one’s fear: attentional bias in anorexia nervosa and healthy individuals upon confrontation with an obese body stimulus in an eye-tracking paradigm. Brain Behav 10:e01834

    Article  PubMed  PubMed Central  Google Scholar 

  • Heitger MH, Jones RD, Macleod AD, Snell DL, Frampton CM, Anderson TJ (2009) Impaired eye movements in post-concussion syndrome indicate suboptimal brain function beyond the influence of depression, malingering or intellectual ability. Brain 132:2850

    Article  PubMed  Google Scholar 

  • Hikosaka O, Takikawa Y, Kawagoe R (2000) Role of the basal ganglia in the control of purposive saccadic eye movements. Physiol Rev 80:953–978

    Article  CAS  PubMed  Google Scholar 

  • Horley K, Williams LM, Gonsalvez C, Gordon E (2003) Social phobics do not see eye to eye: a visual scanpath study of emotional expression processing. J Anxiety Disord 17:33–44

    Article  PubMed  Google Scholar 

  • Horndasch S, Kratz O, Holczinger A, Heinrich H, Hönig F, Nöth E, Moll GH (2012) “Looks do matter” – visual attentional biases in adolescent girls with eating disorders viewing body images. Psychiatry Res 198:321–323

    Article  PubMed  Google Scholar 

  • Horndasch S, Oschmann S, Graap H, Heinrich H, Moll G, Kratz O (2020) Attention towards food: conflicting mechanisms in anorexia nervosa. Appetite 154:104800

    Article  PubMed  Google Scholar 

  • Hutton SB, Ettinger U (2006) The antisaccade task as a research tool in psychopathology: a critical review. Psychophysiology 43:302–313

    Article  PubMed  Google Scholar 

  • Kaye WH, Bulik CM, Thornton L, Barbarich N, Masters K, Group, P. F. C (2004) Comorbidity of anxiety disorders with anorexia and bulimia nervosa. Am J Psychiatr 161:2215–2221

    Article  PubMed  Google Scholar 

  • Keller EL (1974) Participation of medial pontine reticular formation in eye movement generation in monkey. J Neurophysiol 37:316–332

    Article  CAS  PubMed  Google Scholar 

  • Kerr-Gaffney J, Mason L, Jones E, Hayward H, Ahmad J, Harrison A, Loth E, Murphy D, Tchanturia K (2020) Emotion recognition abilities in adults with anorexia nervosa are associated with autistic traits. J Clin Med 9(4):1057

    Google Scholar 

  • Kerr-Gaffney J, Mason L, Jones E, Hayward H, Harrison A, Murphy D, Tchanturia K (2021) Autistic traits mediate reductions in social attention in adults with anorexia nervosa. J Autism Dev Disord 51:2077–2090

    Article  PubMed  Google Scholar 

  • Krappmann P (1998) Accuracy of visually and memory-guided antisaccades in man. Vis Res 38:2979–2985

    Article  CAS  PubMed  Google Scholar 

  • Liversedge SP, Gilchrist ID, Everling S (2011) The Oxford handbook of eye movements. Oxford University Press, New York

    Book  Google Scholar 

  • Lynch JC, Graybiel AM, Lobeck LJ (1985) The differential projection of two cytoarchitectonic subregions of the inferior parietal lobule of macaque upon the deep layers of the superior colliculus. J Comp Neurol 235:241–254

    Article  CAS  PubMed  Google Scholar 

  • McFadyen J, Dolan RJ, Garrido MI (2020) The influence of subcortical shortcuts on disordered sensory and cognitive processing. Nat Rev Neurosci 21:264–276

    Article  CAS  PubMed  Google Scholar 

  • Meredith MA, Stein BE (1986) Visual, auditory, and somatosensory convergence on cells in superior colliculus results in multisensory integration. J Neurophysiol 56:640–662

    Article  CAS  PubMed  Google Scholar 

  • Mitchell JP, Macrae CN, Gilchrist ID (2002) Working memory and the suppression of reflexive saccades. J Cogn Neurosci 14:95–103

    Article  PubMed  Google Scholar 

  • Munoz DP, Everling S (2004) Look away: the anti-saccade task and the voluntary control of eye movement. Nat Rev Neurosci 5:218–228

    Article  CAS  PubMed  Google Scholar 

  • Munoz DP, Wurtz RH (1993a) Fixation cells in monkey superior colliculus. I. Characteristics of cell discharge. J Neurophysiol 70:559–575

    Article  CAS  PubMed  Google Scholar 

  • Munoz DP, Wurtz RH (1993b) Fixation cells in monkey superior colliculus. II. Reversible activation and deactivation. J Neurophysiol 70:576–589

    Article  CAS  PubMed  Google Scholar 

  • Munoz DP, Wurtz RH (1995) Saccade-related activity in monkey superior colliculus. I. Characteristics of burst and buildup cells. J Neurophysiol 73:2313–2333

    Article  CAS  PubMed  Google Scholar 

  • Myles JB, Rossell SL, Phillipou A, Thomas E, Gurvich C (2017) Insights to the schizophrenia continuum: a systematic review of saccadic eye movements in schizotypy and biological relatives of schizophrenia patients. Neurosci Biobehav Rev 72:278–300

    Article  PubMed  Google Scholar 

  • Nobre AC, Gitelman DR, Dias EC, Mesulam MM (2000) Covert visual spatial orienting and saccades: overlapping neural systems. NeuroImage 11:210–216

    Article  CAS  PubMed  Google Scholar 

  • Olk B, Kingstone A (2003) Why are antisaccades slower than prosaccades? A novel finding using a new paradigm. Neuroreport 14:151–155

    Article  PubMed  Google Scholar 

  • Özyurt J, Rutschmann RM, Greenlee MW (2006) Cortical activation during memory-guided saccades. Neuroreport 17:1005

    Article  PubMed  Google Scholar 

  • Pallanti S, Quercioli L, Zaccara G, Ramacciotti AB, Arnetoli G (1998) Eye movement abnormalities in anorexia nervosa. Psychiatry Res 78:59–70

    Article  CAS  PubMed  Google Scholar 

  • Perry RJ, Zeki S (2000) The neurology of saccades and covert shifts in spatial attention an event-related fMRI study. Brain 123:2273–2288

    Article  PubMed  Google Scholar 

  • Phillipou A, Rossell SL, Castle DJ, Gurvich C, Abel LA (2014) Square wave jerks and anxiety as distinctive biomarkers for anorexia nervosa. Invest Ophthalmol Vis Sci 55:8366–8370

    Article  PubMed  Google Scholar 

  • Phillipou A, Abel LA, Castle DJ, Hughes ME, Gurvich C, Nibbs RG, Rossell SL (2015) Self perception and facial emotion perception of others in anorexia nervosa. Front Psychol 6:1–9

    Article  Google Scholar 

  • Phillipou A, Rossell SL, Gurvich C, Castle DJ, Troje NF, Abel LA (2016a) Body image in anorexia nervosa: body size estimation utilising a biological motion task and eyetracking. Eur Eat Disord Rev 24:131–138

    Article  PubMed  Google Scholar 

  • Phillipou A, Rossell SL, Gurvich C, Hughes ME, Castle DJ, Nibbs RG, Abel LA (2016b) Saccadic eye movements in anorexia nervosa. PLoS One 11:1–16

    Article  Google Scholar 

  • Phillipou A, Kirkovski M, Castle DJ, Gurvich C, Abel LA, Miles S, Rossell SL (2019) High-definition transcranial direct current stimulation in anorexia nervosa: a pilot study. Int J Eat Disord 52:1274–1280

    Article  PubMed  Google Scholar 

  • Phillipou A, Abel LA, Gurvich C, Castle DJ, Rossell SL (2020) Eye movements in anorexia nervosa: state or trait markers? Int J Eat Disord 53:1678–1684

    Article  PubMed  Google Scholar 

  • Phillipou A, Rossell S, Gurvich C, Castle D, Meyer D, Abel L (2022) A biomarker and endophenotype for anorexia nervosa? Aust N Z J Psychiatry 56(8):985–993

    Article  PubMed  Google Scholar 

  • Pierrot-Deseilligny C, Rivaud S, Gaymard B, Agid Y (1991) Cortical control of memory-guided saccades in man. Exp Brain Res 83:607–617

    Article  CAS  PubMed  Google Scholar 

  • Pinhas L, Fok KH, Chen A, Lam E, Schachter R, Eizenman O, Grupp L, Eizenman M (2014) Attentional biases to body shape images in adolescents with anorexia nervosa: an exploratory eye-tracking study. Psychiatry Res 220:519–526

    Article  PubMed  Google Scholar 

  • Robinson DA (1972) Eye movements evoked by collicular stimulation in the alert monkey. Vis Res 12:1795–1808

    Article  CAS  PubMed  Google Scholar 

  • Schiller PH, Stryker M (1972) Single-unit recording and stimulation in superior colliculus of the alert rhesus monkey. J Neurophysiol 35:915–924

    Article  CAS  PubMed  Google Scholar 

  • Selemon LD, Goldman-Rakic PS (1988) Common cortical and subcortical targets of the dorsolateral prefrontal and posterior parietal cortices in the rhesus monkey: evidence for a distributed neural network subserving spatially guided behavior. J Neurosci 8:4049–4068

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shook BL, Schlag-Rey M, Schlag J (1990) Primate supplementary eye field: I. Comparative aspects of mesencephalic and pontine connections. J Comp Neurol 301:618–642

    Article  CAS  PubMed  Google Scholar 

  • Sommer MA, Wurtz RH (2000) Composition and topographic organization of signals sent from the frontal eye field to the superior colliculus. J Neurophysiol 83:1979–2001

    Article  CAS  PubMed  Google Scholar 

  • Sommer MA, Wurtz RH (2008) Brain circuits for the internal monitoring of movements. Annu Rev Neurosci 31:317

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sparks DL (2002) The brainstem control of saccadic eye movements. Nat Rev Neurosci 3:952–964

    Article  CAS  PubMed  Google Scholar 

  • Svaldi J, Bender C, Caffier D, Ivanova V, Mies N, Fleischhaker C, Tuschen-Caffier B (2016) Negative mood increases selective attention to negatively valenced body parts in female adolescents with anorexia nervosa. PLoS One 11:e0154462

    Article  PubMed  PubMed Central  Google Scholar 

  • Tallman JF, Paul SM, Skolnick P, Gallager DW (1980) Receptors for the age of anxiety: pharmacology of the benzodiazepines. Science 207:274–281

    Article  CAS  PubMed  Google Scholar 

  • Tuschen-Caffier B, Bender C, Caffier D, Klenner K, Braks K, Svaldi J (2015) Selective visual attention during mirror exposure in anorexia and bulimia nervosa. PLoS One 10:e0145886

    Article  PubMed  PubMed Central  Google Scholar 

  • van’T Ent D, Apkarian P (1999) Motoric response inhibition in finger movement and saccadic eye movement: a comparative study. Clin Neurophysiol 110:1058–1072

    Article  Google Scholar 

  • von Wietersheim J, Kunzl F, Hoffmann H, Glaub J, Rottler E, Traue HC (2012) Selective attention of patients with anorexia nervosa while looking at pictures of their own body and the bodies of others: an exploratory study. Psychosom Med 74:107–113

    Article  Google Scholar 

  • Watson KK, Werling DM, Zucker NL, Platt ML (2010) Altered social reward and attention in anorexia nervosa. Front Psychol 1:36

    Article  PubMed  PubMed Central  Google Scholar 

  • Werthmann J, Simic M, Konstantellou A, Mansfield P, Mercado D, Van Ens W, Schmidt U (2019) Same, same but different: attention bias for food cues in adults and adolescents with anorexia nervosa. Int J Eat Disord 52:681–690

    PubMed  Google Scholar 

  • Williams IM, Ponsford JL, Gibson KL, Mulhall LE, Curran CA, Abel LA (1997) Cerebral control of saccades and neuropsychological test results after head injury. J Clin Neurosci 4:186–196

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Centre for Mental Health, Swinburne University of Technology, Melbourne, VIC, Australia

    Andrea Phillipou

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  1. Andrea Phillipou
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Correspondence to Andrea Phillipou .

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Editors and Affiliations

  1. Department of Biomedical Sciences, University of Westminster, London, UK

    Vinood Patel

  2. Dept Nutrition & Dietetics, King's College London, London, UK

    Victor Preedy

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Phillipou, A. (2022). Anorexia Nervosa and Eye Movements. In: Patel, V., Preedy, V. (eds) Eating Disorders. Springer, Cham. https://doi.org/10.1007/978-3-030-67929-3_32-1

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  • DOI: https://doi.org/10.1007/978-3-030-67929-3_32-1

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  • Print ISBN: 978-3-030-67929-3

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