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Handbook of Substance Misuse and Addictions pp 1–18Cite as

Public Health Issues of Legalizing Cannabis

Considerations for Future Studies

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Abstract

Cannabis has been used by humans for centuries and contains a number of cannabinoid and non-cannabinoid compounds. In the United States, cannabis has a history of and continues to follow a complicated legislative path, with many states legalizing the recreational or medicinal use of cannabis or decriminalizing its use. There have been a number of studies of the therapeutic potential of cannabis and cannabinoids over the past several decades, and there now exists several cannabinoid-based medications for the treatment of various medical conditions. There has also been emerging evidence of adverse health effects linked to cannabis use. Due to legislative changes in cannabis use and possession, individuals have increasingly looked to studies of cannabis health effects to inform decisions related to cannabis and public health. Thus, it is particularly important that future observational studies of cannabis and health effects strive to produce accurate and reliable study results. Study design considerations related to chemical constituents, exposure measurement, health outcome assessment, study design, confounding variables, and the dose-response relationship should be considered in designing future studies and when drawing conclusions related to cannabis-health outcomes in populations.

Keywords

  • Chemical constituents
  • Cannabis
  • Confounding variables
  • Dose-response relationship
  • Health outcome assessment
  • Exposure measurement
  • Legalization
  • Medical marijuana
  • Pharmacokinetics
  • Study design

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Abbreviations

AIDS:

acquired immunodeficiency syndrome

CB1:

cannabinoid-1 receptor

CB2:

cannabinoid-2 receptor

CBD:

cannabidiol

CBN:

cannabinol

CDC:

Centers for Disease Control and Prevention

EVALI:

e-cigarette or vaping associated lung injury

FDA:

United States Food and Drug Administration

NASEM:

National Academies of Sciences, Engineering, and Medicine

THC:

Δ9-tetrahydrocannabinol

US:

United States

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Authors and Affiliations

  1. Gradient, Boston, MA, USA

    Steven R. Boomhower

  2. Harvard Division of Continuing Education, Harvard University, Cambridge, MA, USA

    Steven R. Boomhower

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  1. Steven R. Boomhower
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Correspondence to Steven R. Boomhower .

Editor information

Editors and Affiliations

  1. Department of Biomedical Sciences, University of Westminster, London, UK

    Dr. Vinood B. Patel

  2. Dept of Nutrition & Dietetics, King's College London, London, UK

    Victor R. Preedy

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Boomhower, S.R. (2022). Public Health Issues of Legalizing Cannabis. In: Patel, V.B., Preedy, V.R. (eds) Handbook of Substance Misuse and Addictions. Springer, Cham. https://doi.org/10.1007/978-3-030-67928-6_74-1

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  • DOI: https://doi.org/10.1007/978-3-030-67928-6_74-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-67928-6

  • Online ISBN: 978-3-030-67928-6

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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