Synonyms
Acidophil stem cell adenoma
Clinical Features
Incidence
These rare tumors represent approximately 2% of surgically resected pituitary neuroendocrine tumors (Mete et al. 2018).
Age
These tumors are too rare to have identified any specific age of onset; they have been reported in the pediatric population (Huang et al. 2006).
Sex
These tumors are too rare to have identified any specific gender predilection.
Site
Acidophil stem cell tumors usually arise in the sella turcica. They are usually macrotumors (>1 cm) at the time of diagnosis and often have invasion downwards into the sphenoid sinus as well as invasion upwards and laterally into the cavernous sinuses. They may arise in the sphenoid sinus...
References and Further Reading
Asa, S. L., & Perry, A. (2020). Tumors of the pituitary gland (AFIP atlas of tumor pathology, Series 5). Silver Spring: ARP Press.
Horvath, E., Kovacs, K., Singer, W., Ezrin, C., & Kerenyi, N. A. (1977). Acidophil stem cell adenoma of the human pituitary. Archives of Pathology & Laboratory Medicine, 101, 594–599.
Horvath, E., Kovacs, K., Singer, W., Smyth, H. S., Killinger, D. W., Ezrin, C., et al. (1981). Acidophil stem cell adenoma of the human pituitary: Clinicopathologic analysis of 15 cases. Cancer, 47, 761–771.
Huang, C., Ezzat, S., Asa, S. L., & Hamilton, J. (2006). Dopaminergic resistant prolactinomas in the peripubertal population. Journal of Pediatric Endocrinology & Metabolism, 19, 951–953.
Mete, O., Cintosun, A., Pressman, I., & Asa, S. L. (2018). Epidemiology and biomarker profile of pituitary adenohypophysial tumors. Modern Pathology, 31, 900–909.
Papathomas, T. G., Gaal, J., Corssmit, E. P., Oudijk, L., Korpershoek, E., Heimdal, K., et al. (2014). Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: Aclinicopathological and molecular analysis. European Journal of Endocrinology, 170, 1–12.
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Asa, S.L. (2022). Acidophil Stem Cell Tumor, Pituitary. In: La Rosa, S., Uccella, S. (eds) Endocrine Pathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-62345-6_5032
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DOI: https://doi.org/10.1007/978-3-030-62345-6_5032
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