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Cryotherapy and Argon Ablation of Barrett’s Epithelium

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Gastrointestinal and Pancreatico-Biliary Diseases: Advanced Diagnostic and Therapeutic Endoscopy

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Abstract

Radiofrequency ablation is the best validated and studied ablation method for dysplastic Barrett’s esophagus. However, alternative ablation methods are becoming more widespread and can be useful in areas where RFA is not available. This review will focus on argon plasma coagulation and cryoablation as potential alternatives. We describe the technical aspects and rationale. Available data are summarized and put in perspective.

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Abbreviations

APC:

Argon plasma coagulation

BE:

Barrett’s esophagus

CA:

Cryoablation

CE-D:

Complete eradication of dysplasia

CbFAS:

Cryoballoon focal ablation system

CE-IM:

Complete eradication of intestinal metaplasia

CO2:

Carbon dioxide

EAC:

Esophageal adenocarcinoma

ER:

Endoscopic resection

F-U:

Follow-up

H-APC:

Hybrid argon plasma coagulation

HGD:

High-grade dysplasia

IFD:

Indefinite for dysplasia

ImCA:

Intramucosal cancer

IQR:

Interquartile range

LGD:

Low-grade dysplasia

LNS:

Liquid nitrogen spray

NDBE:

Nondysplastic Barrett’s esophagus

mo:

Month

MPEC:

Multipolar electrocoagulation

N2O:

Mitrous oxide

NR:

Not related

ND:

Nondysplastic

No:

Number

pts:

Patients

PDT:

Photodynamic therapy

PPI:

Proton pump inhibitor

RFA:

Radiofrequency ablation

SD:

Standard deviation

W:

Watt

y:

Year

″:

Second/site

References

  1. Ackroyd R et al (1999) Ablation treatment for Barrett oesophagus: what depth of tissue destruction is needed? J Clin Pathol 52(7):509–512. https://doi.org/10.1136/jcp.52.7.509. England

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Ackroyd R et al (2004) Prospective randomized controlled trial of argon plasma coagulation ablation vs. endoscopic surveillance of patients with Barrett’s esophagus after antireflux surgery. Gastrointest Endosc 59(1):1–7. https://doi.org/10.1016/s0016-5107(03)02528-8. United States

    Article  PubMed  Google Scholar 

  3. Allaf ME et al (2005) Pain control requirements for percutaneous ablation of renal tumors: cryoablation versus radiofrequency ablation – initial observations. Radiology 237(1):366–370. https://doi.org/10.1148/radiol.2371040829. United States

    Article  PubMed  Google Scholar 

  4. Attwood SEA et al (2003) Argon beam plasma coagulation as therapy for high-grade dysplasia in Barrett’s esophagus. Clinical Gastroenterol Hepatol 1(4):258–263. United States

    Article  Google Scholar 

  5. Basu KK et al (2002) Efficacy and one year follow up of argon plasma coagulation therapy for ablation of Barrett’s oesophagus: factors determining persistence and recurrence of Barrett’s epithelium. Gut 51(6):776–780. https://doi.org/10.1136/gut.51.6.776. England

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Berenson MM et al (1993) Restoration of squamous mucosa after ablation of Barrett’s esophageal epithelium. Gastroenterology 104(6):1686–1691. https://doi.org/10.1016/0016-5085(93)90646-t. United States

    Article  CAS  PubMed  Google Scholar 

  7. Bonavina L et al (1999) Endoscopic laser ablation of nondysplastic Barrett’s epithelium: is it worthwhile? J Gastrointest Surg 3(2):194–199. United States

    Article  CAS  Google Scholar 

  8. Brandt LJ, Kauvar DR (1992) Laser-induced transient regression of Barrett’s epithelium. Gastrointest Endosc 38(5):619–622. https://doi.org/10.1016/s0016-5107(92)70536-7. United States

    Article  CAS  PubMed  Google Scholar 

  9. Bright T et al (2007) Randomized trial of argon plasma coagulation versus endoscopic surveillance for Barrett esophagus after antireflux surgery: late results. Ann Surg 246(6):1016–1020. https://doi.org/10.1097/SLA.0b013e318133fa85. United States

    Article  PubMed  Google Scholar 

  10. Bright T et al (2009) Prospective randomized trial of argon plasma coagulation ablation versus endoscopic surveillance of Barrett’s esophagus in patients treated with antisecretory medication. Dig Dis Sci 54(12):2606–2611. https://doi.org/10.1007/s10620-008-0662-7. United States

    Article  PubMed  Google Scholar 

  11. Byrne JP, Armstrong GR, Attwood SE (1998) Restoration of the normal squamous lining in Barrett’s esophagus by argon beam plasma coagulation. Am J Gastroenterol 93(10):1810–1815. https://doi.org/10.1111/j.1572-0241.1998.525_b.x. United States

    Article  CAS  PubMed  Google Scholar 

  12. Canto MI (2017) Cryotherapy for Barrett’s esophagus. Gastrointest Endosc Clin N Am 27(3):503–513. https://doi.org/10.1016/j.giec.2017.03.004. United States

    Article  PubMed  Google Scholar 

  13. Canto MI et al (2015) Safety and efficacy of carbon dioxide cryotherapy for treatment of neoplastic Barrett’s esophagus. Endoscopy 47(7):582–591. https://doi.org/10.1055/s-0034-1391734

    Article  PubMed  Google Scholar 

  14. Canto MI, Shaheen NJ et al (2018a) Multifocal nitrous oxide cryoballoon ablation with or without EMR for treatment of neoplastic Barrett’s esophagus (with video). Gastrointest Endosc 88:438. https://doi.org/10.1016/j.gie.2018.03.024

    Article  PubMed  Google Scholar 

  15. Canto MI, Abrams JA et al (2018b) Nitrous oxide cryotherapy for treatment of esophageal squamous cell neoplasia: initial multicenter international experience with a novel portable cryoballoon ablation system (with video). Gastrointest Endosc 87(2):574–581. https://doi.org/10.1016/j.gie.2017.07.013. United States

    Article  PubMed  Google Scholar 

  16. Chennat J et al (2009) Advanced pathology under squamous epithelium on initial EMR specimens in patients with Barrett’s esophagus and high-grade dysplasia or intramucosal carcinoma: implications for surveillance and endotherapy management. Gastrointest Endosc 70(3):417–421. https://doi.org/10.1016/j.gie.2009.01.047. United States

    Article  PubMed  Google Scholar 

  17. Coletta M et al (2016) Acetic acid chromoendoscopy for the diagnosis of early neoplasia and specialized intestinal metaplasia in Barrett’s esophagus: a meta-analysis. Gastrointest Endosc 83(1):57–67.e1. https://doi.org/10.1016/J.GIE.2015.07.023. Mosby

    Article  PubMed  Google Scholar 

  18. Das A et al (2008) A comparison of endoscopic treatment and surgery in early esophageal cancer: an analysis of surveillance epidemiology and end results data. Am J Gastroenterol 103(6):1340–1345. https://doi.org/10.1111/j.1572-0241.2008.01889.x. United States

    Article  PubMed  Google Scholar 

  19. Desai TK et al (2012) The incidence of oesophageal adenocarcinoma in non-dysplastic Barrett’s oesophagus: a meta-analysis. Gut 61(7):970 LP–970976. Available at: http://gut.bmj.com/content/61/7/970.abstract

    Article  Google Scholar 

  20. Diehl DL, Jain AK, Greenwald BD (2011) Pneumoperitoneum after esophageal cryoablation in a patient with a PEG. Surg Laparosc Endosc Percutan Tech 21(3):e141–e142. https://doi.org/10.1097/SLE.0b013e31821a9034. United States

    Article  PubMed  Google Scholar 

  21. Dulai GS et al (2005) Randomized trial of argon plasma coagulation vs. multipolar electrocoagulation for ablation of Barrett’s esophagus. Gastrointest Endosc 61(2):232–240. https://doi.org/10.1016/s0016-5107(04)02576-3. United States

    Article  PubMed  Google Scholar 

  22. Dumot JA et al (2009) An open-label, prospective trial of cryospray ablation for Barrett’s esophagus high-grade dysplasia and early esophageal cancer in high-risk patients. Gastrointest Endosc 70(4):635–644. https://doi.org/10.1016/j.gie.2009.02.006. United States

    Article  PubMed  Google Scholar 

  23. Dumoulin FL et al (1997) Treatment of Barrett’s esophagus by endoscopic argon plasma coagulation. Endoscopy 29(8):751–753. https://doi.org/10.1055/s-2007-1004302. Germany

    Article  CAS  PubMed  Google Scholar 

  24. Dunbar KB, Souza RF (2017) Beyond dysplasia grade. Gastrointest Endosc Clin 27(3):447–459. https://doi.org/10.1016/j.giec.2017.02.003. Elsevier

    Article  Google Scholar 

  25. Ell C et al (2007) Curative endoscopic resection of early esophageal adenocarcinomas (Barrett’s cancer). Gastrointest Endosc 65(1):3–10. https://doi.org/10.1016/j.gie.2006.04.033. United States

    Article  PubMed  Google Scholar 

  26. Erinjeri JP, Clark TWI (2010) Cryoablation: mechanism of action and devices. J Vasc Interv Radiol 21(8 Suppl):S187–S191. https://doi.org/10.1016/j.jvir.2009.12.403. United States

    Article  PubMed  PubMed Central  Google Scholar 

  27. Evonich RF 3rd, Nori DM, Haines DE (2007) A randomized trial comparing effects of radiofrequency and cryoablation on the structural integrity of esophageal tissue. J Interv Card Electrophysiol 19(2):77–83. https://doi.org/10.1007/s10840-007-9142-9. Netherlands

    Article  PubMed  Google Scholar 

  28. Faigel DO et al (2002) Effect of multipolar electrocoagulation on EUS findings in Barrett’s esophagus. Gastrointest Endosc 55(1):23–26. https://doi.org/10.1067/mge.2002.120100. United States

    Article  PubMed  Google Scholar 

  29. Ferraris R et al (2007) Barrett’s oesophagus: long-term follow-up after complete ablation with argon plasma coagulation and the factors that determine its recurrence. Aliment Pharmacol Ther 25(7):835–840. https://doi.org/10.1111/j.1365-2036.2007.03251.x. England

    Article  CAS  PubMed  Google Scholar 

  30. Fink MA, Martin CJ, Ewing HP, Thompson ME, Macher D, R. J. (1992) Reversal of experimental Barrett’s esophagus by endoscopic laser ablation and reduction of acid reflux [abstract]. Gastroenterology 102:A924

    Article  Google Scholar 

  31. Franchimont D, Van Laethem J-L, Deviere J (2003) Argon plasma coagulation in Barrett’s esophagus. Gastrointest Endosc Clin N Am 13(3):457–466. United States

    Article  Google Scholar 

  32. Friedland S, Triadafilopoulos G (2011) A novel device for ablation of abnormal esophageal mucosa (with video). Gastrointest Endosc 74(1):182–188. https://doi.org/10.1016/j.gie.2011.03.1119. United States

    Article  PubMed  Google Scholar 

  33. Fujishiro M et al (2006) Submucosal injection of normal saline may prevent tissue damage from argon plasma coagulation: an experimental study using resected porcine esophagus, stomach, and colon. Surg Laparosc Endosc Percutan Tech 16(5):307–311. https://doi.org/10.1097/01.sle.0000213739.85277.3d. United States

    Article  PubMed  Google Scholar 

  34. Fujishiro M et al (2008) Submucosal injection of normal saline can prevent unexpected deep thermal injury of argon plasma coagulation in the in vivo porcine stomach. Gut and liver 2(2):95–98. https://doi.org/10.5009/gnl.2008.2.2.95.. Korea (South)

    Article  PubMed  PubMed Central  Google Scholar 

  35. Gage AA, Baust J (1998) Mechanisms of tissue injury in cryosurgery. Cryobiology 37(3):171–186. https://doi.org/10.1006/cryo.1998.2115. Netherlands

    Article  CAS  PubMed  Google Scholar 

  36. Ganz RA et al (2004) Complete ablation of esophageal epithelium with a balloon-based bipolar electrode: a phased evaluation in the porcine and in the human esophagus. Gastrointest Endosc 60(6):1002–1010. https://doi.org/10.1016/s0016-5107(04)02220-5. United States

    Article  PubMed  Google Scholar 

  37. Ghorbani S et al (2016) Safety and efficacy of endoscopic spray cryotherapy for Barrett’s dysplasia: results of the National Cryospray Registry. Dis Esophagus 29:241. https://doi.org/10.1111/dote.12330

    Article  CAS  PubMed  Google Scholar 

  38. Glover JL et al (1982) The plasma scalpel: a new thermal knife. Lasers Surg Med 2(1):101–106. https://doi.org/10.1002/lsm.1900020113. United States

    Article  CAS  PubMed  Google Scholar 

  39. Goldberg ME, Horwhat D, Cash BD (2012) Tu1609 long-term analysis of outcomes associated with endoscopic spray cryotherapy for Barrett’s esophagus with and without dysplasia. Gastrointest Endosc 75(4):AB463. https://doi.org/10.1016/j.gie.2012.03.1255. Elsevier

    Article  Google Scholar 

  40. Gosain S et al (2013) Liquid nitrogen spray cryotherapy in Barrett’s esophagus with high-grade dysplasia: long-term results. Gastrointest Endosc 78(2):260–265. https://doi.org/10.1016/j.gie.2013.03.002. United States

    Article  PubMed  Google Scholar 

  41. Grade AJ et al (1999) The efficacy and safety of argon plasma coagulation therapy in Barrett’s esophagus. Gastrointest Endosc 50(1):18–22. https://doi.org/10.1016/s0016-5107(99)70338-x. United States

    Article  CAS  PubMed  Google Scholar 

  42. Gray NA, Odze RD, Spechler SJ (2011) Buried metaplasia after endoscopic ablation of Barrett’s esophagus: a systematic review. Am J Gastroenterol 106(11):1899–1908; quiz 1909. https://doi.org/10.1038/ajg.2011.255. United States

  43. Greenwald BD, Dumot JA (2011) Cryotherapy for Barrett’s esophagus and esophageal cancer. Curr Opin Gastroenterol 27(4):363–367. https://doi.org/10.1097/MOG.0b013e328347bae8. United States

    Article  PubMed  Google Scholar 

  44. Greenwald BD et al (2010) Safety, tolerability, and efficacy of endoscopic low-pressure liquid nitrogen spray cryotherapy in the esophagus. Dis Esophagus 23(1):13–19. https://doi.org/10.1111/j.1442-2050.2009.00991.x. United States

    Article  PubMed  Google Scholar 

  45. Grund KE (1997) Argon plasma coagulation (APC): ballyhoo or breakthrough? Endoscopy 29:196–198. https://doi.org/10.1055/s-2007-1004163. Germany

    Article  CAS  PubMed  Google Scholar 

  46. Grund KE, Storek D, Farin G (1994) Endoscopic argon plasma coagulation (APC) first clinical experiences in flexible endoscopy. Endosc Surg Allied Technol 2(1):42–46. Germany

    CAS  PubMed  Google Scholar 

  47. Haidry RJ et al (2013) Radiofrequency ablation and endoscopic mucosal resection for dysplastic barrett’s esophagus and early esophageal adenocarcinoma: outcomes of the UK National Halo RFA Registry. Gastroenterology. United States 145(1):87–95. https://doi.org/10.1053/j.gastro.2013.03.045

    Article  PubMed  Google Scholar 

  48. Halsey KD et al (2011) Recurrent disease following endoscopic ablation of Barrett’s high-grade dysplasia with spray cryotherapy. Endoscopy 43(10):844–848. https://doi.org/10.1055/s-0030-1256649. Germany

    Article  CAS  PubMed  Google Scholar 

  49. Hamade N et al (2019) Efficacy of cryotherapy as first line therapy in patients with Barrett’s neoplasia: a systematic review and pooled analysis. Dis Esophagus 32. https://doi.org/10.1093/dote/doz040. United States

  50. Hvid-Jensen F et al (2011) Incidence of adenocarcinoma among patients with Barrett’s esophagus. N Engl J Med Mass Med Soc 365(15):1375–1383. https://doi.org/10.1056/NEJMoa1103042.

    Article  CAS  Google Scholar 

  51. Johnston MH (2003) Cryotherapy and other newer techniques. Gastrointest Endosc Clin N Am 13(3):491–504. United States

    Article  Google Scholar 

  52. Johnston MH (2013) Sa1388 low pressure cryospray ablation of high grade dysplasia in Barrett’s esophagus: 2 year follow-up. Gastrointest Endosc 77(5):AB187. https://doi.org/10.1016/j.gie.2013.03.439. Elsevier

    Article  Google Scholar 

  53. Johnston CM et al (1999) Endoscopic spray cryotherapy: a new technique for mucosal ablation in the esophagus. Gastrointest Endosc 50(1):86–92. United States

    Article  CAS  Google Scholar 

  54. Johnston MH et al (2005) Cryoablation of Barrett’s esophagus: a pilot study. Gastrointest Endosc 62(6):842–848. https://doi.org/10.1016/j.gie.2005.05.008. United States

    Article  PubMed  Google Scholar 

  55. Kahaleh M et al (2002) Long-term follow-up and factors predictive of recurrence in Barrett’s esophagus treated by argon plasma coagulation and acid suppression. Endoscopy 34(12):950–955. https://doi.org/10.1055/s-2002-35847. Germany

    Article  CAS  PubMed  Google Scholar 

  56. Kunzli HT et al (2017) Efficacy of the CryoBalloon Focal Ablation System for the eradication of dysplastic Barrett’s esophagus islands. Endoscopy 49(2):169–175. https://doi.org/10.1055/s-0042-120117. Germany

    Article  PubMed  Google Scholar 

  57. Lal P, Thota PN (2018) Cryotherapy in the management of premalignant and malignant conditions of the esophagus. World J Gastroenterol 24(43):4862–4869. https://doi.org/10.3748/wjg.v24.i43.4862. United States

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Laukka MA, Wang KK (1995) Initial results using low-dose photodynamic therapy in the treatment of Barrett’s esophagus. Gastrointest Endosc 42(1):59–63. https://doi.org/10.1016/s0016-5107(95)70245-8. United States

    Article  CAS  PubMed  Google Scholar 

  59. Louie BE et al (2018) Evaluation of a novel cryoballoon swipe ablation system in bench, porcine, and human esophagus models. Dis Esophagus 31(8). https://doi.org/10.1093/dote/dox155. United States

  60. Madisch A et al (2005) Long-term follow-up after complete ablation of Barrett’s esophagus with argon plasma coagulation. World J Gastroenterol 11(8):1182–1186. https://doi.org/10.3748/wjg.v11.i8.1182. United States

    Article  PubMed  PubMed Central  Google Scholar 

  61. Manner H (2008) Argon plasma coagulation therapy. Curr Opin Gastroenterol 24(5):612–616. https://doi.org/10.1097/MOG.0b013e32830bf825. United States

    Article  CAS  PubMed  Google Scholar 

  62. Manner H et al (2006) Ablation of nonneoplastic Barrett’s mucosa using argon plasma coagulation with concomitant esomeprazole therapy (APBANEX): a prospective multicenter evaluation. Am J Gastroenterol 101(8):1762–1769. https://doi.org/10.1111/j.1572-0241.2006.00709.x. United States

    Article  CAS  PubMed  Google Scholar 

  63. Manner H, Rabenstein T et al (2014a) Ablation of residual Barrett’s epithelium after endoscopic resection: a randomized long-term follow-up study of argon plasma coagulation vs. surveillance (APE study). Endoscopy 46(1):6–12. https://doi.org/10.1055/s-0033-1358813. Germany

    Article  PubMed  Google Scholar 

  64. Manner H, Neugebauer A et al (2014b) The tissue effect of argon-plasma coagulation with prior submucosal injection (Hybrid-APC) versus standard APC: a randomized ex-vivo study. United European Gastroenterol J 2(5):383–390. https://doi.org/10.1177/2050640614544315. England

    Article  PubMed  PubMed Central  Google Scholar 

  65. Manner H et al (2016) Efficacy and safety of Hybrid-APC for the ablation of Barrett’s esophagus. Surg Endosc 30(4):1364–1370. https://doi.org/10.1007/s00464-015-4336-1. Germany

    Article  PubMed  Google Scholar 

  66. Martin WR et al (1999) Treatment of Barrett esophagus with argon plasma coagulation with acid suppression – a prospective study. Z Gastroenterol 37(9):779–784. Germany

    CAS  PubMed  Google Scholar 

  67. May A et al (2002) Local endoscopic therapy for intraepithelial high-grade neoplasia and early adenocarcinoma in Barrett’s oesophagus: acute-phase and intermediate results of a new treatment approach. Eur J Gastroenterol Hepatol 14(10):1085–1091. https://doi.org/10.1097/00042737-200210000-00009. England

    Article  PubMed  Google Scholar 

  68. Milashka M et al (2014) Sixteen-year follow-up of Barrett’s esophagus, endoscopically treated with argon plasma coagulation. United European Gastroenterol J 2(5):367–373. https://doi.org/10.1177/2050640614549095. England

    Article  PubMed  PubMed Central  Google Scholar 

  69. Mohan BP et al (2019) Liquid nitrogen spray cryotherapy in treatment of Barrett’s esophagus, where do we stand? A systematic review and meta-analysis. Dis Esophagus 32(6). https://doi.org/10.1093/dote/doy130. United States

  70. Morino M et al (2003) Endoscopic ablation of Barrett’s esophagus using argon plasma coagulation (APC) following surgical laparoscopic fundoplication. Surg Endosc 17(4):539–542. https://doi.org/10.1007/s00464-002-9119-9. Germany

    Article  CAS  PubMed  Google Scholar 

  71. Mork H et al (1998) Reconstitution of squamous epithelium in Barrett’s oesophagus with endoscopic argon plasma coagulation: a prospective study. Scand J Gastroenterol 33(11):1130–1134. https://doi.org/10.1080/00365529850172458. England

    Article  CAS  PubMed  Google Scholar 

  72. Morris CD et al (2001) Prevention of the neoplastic progression of Barrett’s oesophagus by endoscopic argon beam plasma ablation. Br J Surg 88(10):1357–1362. https://doi.org/10.1046/j.0007-1323.2001.01926.x. England

    Article  CAS  PubMed  Google Scholar 

  73. Moss A et al (2010) Endoscopic resection for Barrett’s high-grade dysplasia and early esophageal adenocarcinoma: an essential staging procedure with long-term therapeutic benefit. Am J Gastroenterol 105(6):1276–1283. https://doi.org/10.1038/ajg.2010.1. United States

    Article  PubMed  Google Scholar 

  74. Oh DS et al (2006) Clinical biology and surgical therapy of intramucosal adenocarcinoma of the esophagus. J Am Coll Surg 203(2):152–161. https://doi.org/10.1016/j.jamcollsurg.2006.05.006. United States

    Article  PubMed  Google Scholar 

  75. Orman ES, Li N, Shaheen NJ (2013) Efficacy and durability of radiofrequency ablation for Barrett’s esophagus: systematic review and meta-analysis. Clin Gastroenterol Hepatol 11(10):1245–1255. https://doi.org/10.1016/j.cgh.2013.03.039. United States

    Article  PubMed  Google Scholar 

  76. Otaki F, Iyer PG (2018) Point-counterpoint: screening and surveillance for Barrett’s esophagus, is it worthwhile? Dig Dis Sci 63(8):2081–2093. https://doi.org/10.1007/s10620-018-5065-9. United States

    Article  PubMed  Google Scholar 

  77. Overwater A, Weusten BLAM (2017) Cryoablation in the management of Barrett’s esophagus. Curr Opin Gastroenterol 33(4):261–269. https://doi.org/10.1097/MOG.0000000000000372. United States

    Article  PubMed  Google Scholar 

  78. Pagani M et al (2003) Barrett’s esophagus: combined treatment using argon plasma coagulation and laparoscopic antireflux surgery. Dis Esophagus 16(4):279–283. https://doi.org/10.1111/j.1442-2050.2003.00347.x. United States

    Article  CAS  PubMed  Google Scholar 

  79. Pasricha PJ et al (1999) Endoscopic cryotherapy: experimental results and first clinical use. Gastrointest Endosc 49(5):627–631. https://doi.org/10.1016/s0016-5107(99)70393-7. United States

    Article  CAS  PubMed  Google Scholar 

  80. Pech O et al (2008) Long-term results and risk factor analysis for recurrence after curative endoscopic therapy in 349 patients with high-grade intraepithelial neoplasia and mucosal adenocarcinoma in Barrett’s oesophagus. Gut 57(9):1200–1206. https://doi.org/10.1136/gut.2007.142539. England

    Article  CAS  PubMed  Google Scholar 

  81. Pech O et al (2011) Comparison between endoscopic and surgical resection of mucosal esophageal adenocarcinoma in Barrett’s esophagus at two high-volume centers. Ann Surg 254(1):67–72. https://doi.org/10.1097/SLA.0b013e31821d4bf6. United States

    Article  PubMed  Google Scholar 

  82. Pedrazzani C et al (2005) Endoscopic ablation of Barrett’s esophagus using high power setting argon plasma coagulation: a prospective study. World J Gastroenterol 11(12):1872–1875. https://doi.org/10.3748/wjg.v11.i12.1872. United States

    Article  PubMed  PubMed Central  Google Scholar 

  83. Peerally MF et al (2019) Radiofrequency ablation compared with argon plasma coagulation after endoscopic resection of high-grade dysplasia or stage T1 adenocarcinoma in Barrett’s esophagus: a randomized pilot study (BRIDE). Gastrointest Endosc 89(4):680–689. https://doi.org/10.1016/j.gie.2018.07.031. United States

    Article  PubMed  Google Scholar 

  84. Pereira-Lima JC et al (2000) High power setting argon plasma coagulation for the eradication of Barrett’s esophagus. Am J Gastroenterol 95(7):1661–1668. https://doi.org/10.1111/j.1572-0241.2000.02197.x. United States

    Article  CAS  PubMed  Google Scholar 

  85. Peters FP et al (2005) Endoscopic treatment of high-grade dysplasia and early stage cancer in Barrett’s esophagus. Gastrointest Endosc 61(4):506–514. United States

    Article  Google Scholar 

  86. Phoa KN et al (2014) Radiofrequency ablation vs endoscopic surveillance for patients with Barrett esophagus and low-grade dysplasia: a randomized clinical trial. JAMA 311(12):1209–1217. https://doi.org/10.1001/jama.2014.2511. United States

    Article  CAS  PubMed  Google Scholar 

  87. Phoa KN et al (2016) Multimodality endoscopic eradication for neoplastic Barrett oesophagus: results of an European multicentre study (EURO-II). Gut 65(4):555–562. https://doi.org/10.1136/gutjnl-2015-309298. England

    Article  CAS  PubMed  Google Scholar 

  88. Pinotti AC et al (2004) Endoscopic ablation of Barrett’s esophagus using argon plasma coagulation: a prospective study after fundoplication. Dis Esophagus 17(3):243–246. https://doi.org/10.1111/j.1442-2050.2004.00415.x. United States

    Article  CAS  PubMed  Google Scholar 

  89. Pouw RE et al (2014) Pseudo-buried Barrett’s post radiofrequency ablation for Barrett’s esophagus, with or without prior endoscopic resection. Endoscopy 46(2):105–109. https://doi.org/10.1055/s-0033-1358883. Germany

    Article  PubMed  Google Scholar 

  90. Prasad GA et al (2009) Endoscopic and surgical treatment of mucosal (T1a) esophageal adenocarcinoma in Barrett’s esophagus. Gastroenterology 137(3):815–823. https://doi.org/10.1053/j.gastro.2009.05.059. United States

    Article  PubMed  Google Scholar 

  91. Ramay FH, Cui Q, Greenwald BD (2017) Outcomes after liquid nitrogen spray cryotherapy in Barrett’s esophagus-associated high-grade dysplasia and intramucosal adenocarcinoma: 5-year follow-up. Gastrointest Endosc 86(4):626–632. https://doi.org/10.1016/j.gie.2017.02.006. United States

    Article  PubMed  PubMed Central  Google Scholar 

  92. Ribeiro A et al (2014) Depth of injury caused by liquid nitrogen cryospray: study of human patients undergoing planned esophagectomy. Dig Dis Sci 59(6):1296–1301. https://doi.org/10.1007/s10620-013-2991-4

    Article  CAS  PubMed  Google Scholar 

  93. Rösch T et al (2017) 1151 Multicenter feasibility study of combined injection and argon plasma coagulation (Hybrid-APC) in the ablation therapy of neoplastic Barrett esophagus. Gastrointest Endosc 85(5):AB154. https://doi.org/10.1016/j.gie.2017.03.331. Elsevier

    Article  Google Scholar 

  94. Rösch T et al (2018) 479 Multicenter feasibility study of combined injection and argon plasma coagulation (Hybrid-APC) in ablation therapy of neoplastic Barrett’s esophagus. Gastrointest Endosc 87(6):AB82. https://doi.org/10.1016/j.gie.2018.04.088. Elsevier

    Article  Google Scholar 

  95. Samarasena J et al (2017) Successful closure of a cryotherapy-induced bleeding jejunal perforation with the over-the-scope clip system. Gastrointest Endosc 85(2):451. https://doi.org/10.1016/j.gie.2016.10.038. United States

    Article  PubMed  Google Scholar 

  96. Sampliner RE, Fennerty B, Garewal HS (1996) Reversal of Barrett’s esophagus with acid suppression and multipolar electrocoagulation: preliminary results. Gastrointest Endosc 44(5):532–535. United States

    Article  CAS  Google Scholar 

  97. Scholvinck DW et al (2015) Treatment of Barrett’s esophagus with a novel focal cryoablation device: a safety and feasibility study. Endoscopy 47(12):1106–1112. https://doi.org/10.1055/s-0034-1392417. Germany

    Article  PubMed  Google Scholar 

  98. Scholvinck DW et al (2017) Balloon-based esophageal cryoablation with a novel focal ablation device: dose-finding and safety in porcine and human models. Dis Esophagus 30(11):1–8. https://doi.org/10.1093/dote/dox019. United States

    Article  CAS  PubMed  Google Scholar 

  99. Schulz H et al (2000) Ablation of Barrett’s epithelium by endoscopic argon plasma coagulation in combination with high-dose omeprazole. Gastrointest Endosc 51(6):659–663. United States

    CAS  PubMed  Google Scholar 

  100. Sengupta N et al (2015) Salvage cryotherapy after failed radiofrequency ablation for Barrett’s esophagus-related dysplasia is safe and effective. Gastrointest Endosc 82(3):443–448. https://doi.org/10.1016/j.gie.2015.01.033

    Article  PubMed  Google Scholar 

  101. Shaheen NJ et al (2000) Is there publication bias in the reporting of cancer risk in Barrett’s esophagus? Gastroenterology 119(2):333–338. United States

    Article  CAS  Google Scholar 

  102. Shaheen NJ et al (2009) Radiofrequency ablation in Barrett’s esophagus with dysplasia. N Engl J Med 360(22):2277–2288. https://doi.org/10.1056/NEJMoa0808145. United States

    Article  CAS  PubMed  Google Scholar 

  103. Shaheen NJ et al (2010) Safety and efficacy of endoscopic spray cryotherapy for Barrett’s esophagus with high-grade dysplasia. Gastrointest Endosc. United States 71(4):680–685. https://doi.org/10.1016/j.gie.2010.01.018

    Article  PubMed  PubMed Central  Google Scholar 

  104. Shaheen NJ et al (2011) Durability of radiofrequency ablation in Barrett’s esophagus with dysplasia. Gastroenterology 141(2):460–468. https://doi.org/10.1053/j.gastro.2011.04.061. United States

    Article  PubMed  Google Scholar 

  105. Shaheen NJ et al (2016) ACG clinical guideline: diagnosis and management of Barrett’s esophagus. Am J Gastroenterol. https://doi.org/10.1038/ajg.2015.322

  106. Shand A et al (2001) Adenocarcinoma arising in columnar lined oesophagus following treatment with argon plasma coagulation. Gut:580–581. https://doi.org/10.1136/gut.48.4.580b. England

  107. Sharma P et al (2006a) A randomised controlled trial of ablation of Barrett’s oesophagus with multipolar electrocoagulation versus argon plasma coagulation in combination with acid suppression: long term results. Gut 55(9):1233–1239. https://doi.org/10.1136/gut.2005.086777. England

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  108. Sharma P et al (2006b) Dysplasia and Cancer in a large Multicenter cohort of patients with Barrett’s esophagus. Clin Gastroenterol Hepatol 4(5):566–572. https://doi.org/10.1016/j.cgh.2006.03.001

    Article  PubMed  Google Scholar 

  109. Sie C et al (2013) Argon plasma coagulation ablation versus endoscopic surveillance of Barrett’s esophagus: late outcomes from two randomized trials. Endoscopy 45(11):859–865. https://doi.org/10.1055/s-0033-1344584. Germany

    Article  PubMed  Google Scholar 

  110. Solomon SS et al (2019) Liquid Nitrogen spray cryotherapy is associated with less postprocedural pain than radiofrequency ablation in Barrett’s esophagus: a multicenter prospective study. J Clin Gastroenterol 53(2):e84–e90. https://doi.org/10.1097/MCG.0000000000000999. United States

    Article  CAS  PubMed  Google Scholar 

  111. Spiceland CM et al (2019) Salvage cryotherapy in patients undergoing endoscopic eradication therapy for complicated Barrett’s esophagus. Endosc Int Open 7(7):E904–E911. https://doi.org/10.1055/a-0902-4587. Germany

    Article  PubMed  PubMed Central  Google Scholar 

  112. Stein HJ, Siewert JR (1993) Barrett’s esophagus: pathogenesis, epidemiology, functional abnormalities, malignant degeneration, and surgical management. Dysphagia 8(3):276–288. https://doi.org/10.1007/BF01354551

    Article  CAS  PubMed  Google Scholar 

  113. Stein HJ et al (2005) Early esophageal cancer: pattern of lymphatic spread and prognostic factors for long-term survival after surgical resection. Ann Surg 242(4):565–566. https://doi.org/10.1097/01.sla.0000184211.75970.85. United States

    Article  Google Scholar 

  114. Suchniak-Mussari K et al (2017) Efficacy and safety of liquid nitrogen cryotherapy for treatment of Barrett’s esophagus. World J Gastrointest Endosc 9(9):480–485. https://doi.org/10.4253/wjge.v9.i9.480. United States

    Article  PubMed  PubMed Central  Google Scholar 

  115. Thota PN et al (2018) Cryotherapy and radiofrequency ablation for eradication of Barrett’s esophagus with dysplasia or intramucosal cancer. Dig Dis Sci 63(5):1311–1319. https://doi.org/10.1007/s10620-018-5009-4. Springer US

    Article  PubMed  PubMed Central  Google Scholar 

  116. Tigges H et al (2001) Combination of endoscopic argon plasma coagulation and antireflux surgery for treatment of Barrett’s esophagus. J Gastrointest Surg 5(3):251–259. United States

    Article  CAS  Google Scholar 

  117. Trindade AJ et al (2017) Feasibility of liquid nitrogen cryotherapy after failed radiofrequency ablation for Barrett’s esophagus. Dig Endosc 29(6):680–685. https://doi.org/10.1111/den.12869

    Article  PubMed  Google Scholar 

  118. Trindade AJ et al (2018) Efficacy of liquid nitrogen cryotherapy for Barrett’s esophagus after endoscopic resection of intramucosal cancer: a multicenter study. J Gastroenterol Hepatol 33(2):461–465. https://doi.org/10.1111/jgh.13909. Australia

    Article  CAS  PubMed  Google Scholar 

  119. Van Laethem JL et al (1998) Eradication of Barrett’s mucosa with argon plasma coagulation and acid suppression: immediate and midterm results. Gut 43(6):747–751. https://doi.org/10.1136/gut.43.6.747. England

    Article  PubMed  PubMed Central  Google Scholar 

  120. Van Laethem JL et al (2000) Intramucosal adenocarcinoma arising under squamous re-epithelialisation of Barrett’s oesophagus. Gut 46(4):574–577. https://doi.org/10.1136/gut.46.4.574. England

    Article  PubMed  PubMed Central  Google Scholar 

  121. Van Laethem JL et al (2001) Argon plasma coagulation in the treatment of Barrett’s high-grade dysplasia and in situ adenocarcinoma. Endoscopy 33(3):257–261. https://doi.org/10.1055/s-2001-12803. Germany

    Article  PubMed  Google Scholar 

  122. van Munster SN et al (2018) Focal cryoballoon versus radiofrequency ablation of dysplastic Barrett’s esophagus: impact on treatment response and postprocedural pain. Gastrointest Endosc 88(5):795–803.e2. https://doi.org/10.1016/j.gie.2018.06.015

    Article  PubMed  Google Scholar 

  123. van Munster SN, Pouw RE, Bergman JJGHM (2019) Randomized studies for Barrett’s ablation: just because we can doesn’t mean we should. Gastrointest Endosc:690–692. https://doi.org/10.1016/j.gie.2018.11.007. United States

  124. Vargo JJ (2004) Clinical applications of the argon plasma coagulator. Gastrointest Endosc 59(1):81–88. https://doi.org/10.1016/s0016-5107(03)02296-x. United States

    Article  PubMed  Google Scholar 

  125. Verbeek RE et al (2015) Cryospray ablation using pressurized CO2 for ablation of Barrett’s esophagus with early neoplasia: early termination of a prospective series. Endosc Int open:E107–E112. https://doi.org/10.1055/s-0034-1390759. Germany

  126. Visrodia K et al (2018a) Cryotherapy for persistent Barrett’s esophagus after radiofrequency ablation: a systematic review and meta-analysis. Gastrointest Endosc 87(6):1396–1404.e1. https://doi.org/10.1016/j.gie.2018.02.021. United States

    Article  PubMed  PubMed Central  Google Scholar 

  127. Visrodia K, Zakko L, Wang KK (2018b) Mucosal ablation in patients with Barrett’s esophagus: fry or freeze? Dig Dis Sci 63(8):2129–2135. https://doi.org/10.1007/s10620-018-5064-x

    Article  PubMed  Google Scholar 

  128. Wahab PJ et al (1997) Argon plasma coagulation in flexible gastrointestinal endoscopy: pilot experiences. Endoscopy 29(3):176–181. https://doi.org/10.1055/s-2007-1004159. Germany

    Article  CAS  PubMed  Google Scholar 

  129. Wani S et al (2009) Esophageal adenocarcinoma in Barrett’s esophagus after endoscopic ablative therapy: a meta-analysis and systematic review. Am J Gastroenterol 104(2):502–513. https://doi.org/10.1038/ajg.2008.31. United States

    Article  PubMed  Google Scholar 

  130. Wani S et al (2018) Endoscopic eradication therapy for patients with Barrett’s esophagus-associated dysplasia and intramucosal cancer. Gastrointest Endosc 87(4):907–931.e9. https://doi.org/10.1016/j.gie.2017.10.011. United States

    Article  PubMed  Google Scholar 

  131. Weston AP et al (2005) Visible endoscopic and histologic changes in the cardia, before and after complete Barrett’s esophagus ablation. Gastrointest Endosc 61(4):515–521. United States

    Article  Google Scholar 

  132. Weusten BLAM, Bergman JJGHM (2015) Cryoablation for managing Barrett’s esophagus refractory to radiofrequency ablation? Don’t embrace the cold too soon! Gastrointest Endosc 82(3):449–451. https://doi.org/10.1016/j.gie.2015.03.1965

    Article  PubMed  Google Scholar 

  133. Weusten B et al (2017) Endoscopic management of Barrett’s esophagus: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement. Endoscopy 49(02):191–198. https://doi.org/10.1055/s-0042-122140

    Article  PubMed  Google Scholar 

  134. Wijnhoven BP et al (1999) Adenocarcinomas of the distal oesophagus and gastric cardia are one clinical entity. Rotterdam Oesophageal Tumour Study Group. Br J Surg 86(4):529–535. https://doi.org/10.1046/j.1365-2168.1999.01082.x. England

    Article  CAS  PubMed  Google Scholar 

  135. Xue HB et al (2011) A pilot study of endoscopic spray cryotherapy by pressurized carbon dioxide gas for Barrett’s esophagus. Endoscopy 43(5):379–385. https://doi.org/10.1055/s-0030-1256334. Germany

    Article  CAS  PubMed  Google Scholar 

  136. Zhou C et al (2012) Characterization of buried glands before and after radiofrequency ablation by using 3-dimensional optical coherence tomography (with videos). Gastrointest Endosc 76(1):32–40. https://doi.org/10.1016/j.gie.2012.02.003. United States

    Article  PubMed  PubMed Central  Google Scholar 

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  1. Gastroenterology and Hepatology, University Hospital Leuven, Leuven, Belgium

    Philippe Leclercq & Raf Bisschops

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  1. Philippe Leclercq
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  1. Division of Gastroenterology and Gastrointestinal Endoscopy IRCCS, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

    Pier Alberto Testoni

  2. Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan

    Haruhiro Inoue

  3. Department of Gastroenterology and Hepatology, Mayo Clinic Florida, Jacksonville, FL, USA

    Michael B. Wallace

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  1. Cancer Center, Mayo Clinic, Jacksonville, FL, USA

    Michael B. Wallace

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Leclercq, P., Bisschops, R. (2022). Cryotherapy and Argon Ablation of Barrett’s Epithelium. In: Testoni, P.A., Inoue, H., Wallace, M.B. (eds) Gastrointestinal and Pancreatico-Biliary Diseases: Advanced Diagnostic and Therapeutic Endoscopy. Springer, Cham. https://doi.org/10.1007/978-3-030-56993-8_7

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