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Sublingual Route of Drug Delivery

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The ADME Encyclopedia

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Overview on the Sublingual Drug Administration

Sublingual drug administration is the process of placing a dosage form (usually tablets, lozenges, or strips) under the tongue where it dissolves completely, allowing the drug to directly reach systemic blood circulation upon absorption. Sublingual drops and sprays are also administered via this route. Many small- and macromolecules have been successfully absorbed following their sublingual administration [1,2,3]. Sublingual administration is commonly used for both local and systemic drug treatments [4]. Protection of drugs against destruction by the gastric acid and the intestinal and hepatic enzymes is achieved by this route. The delivery of a drug through the sublingual route is favorable due to the substantially rich blood and lymphatic vessel supply.

As with other routes of administration, drug delivery and absorption from this route depend on the drug permeability across the sublingual mucosa, the drug physicochemical properties, and...

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References

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Authors and Affiliations

  1. Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia

    Tarek A. Ahmed & Khalid M. El-Say

  2. Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt

    Tarek A. Ahmed & Khalid M. El-Say

Authors
  1. Tarek A. Ahmed
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  2. Khalid M. El-Say
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Corresponding author

Correspondence to Tarek A. Ahmed .

Section Editor information

  1. Quality Control of Pharmaceutical Products, National University of La Plata, La Plata, Argentina

    María Esperanza Ruiz

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Ahmed, T.A., El-Say, K.M. (2021). Sublingual Route of Drug Delivery. In: The ADME Encyclopedia. Springer, Cham. https://doi.org/10.1007/978-3-030-51519-5_95-1

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  • DOI: https://doi.org/10.1007/978-3-030-51519-5_95-1

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  • Print ISBN: 978-3-030-51519-5

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