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The Beneficial Role of Natural Antioxidants in Alleviating Neuroinflammatory Disorders Including Neurodegeneration

Book cover Plant Antioxidants and Health

Part of the book series: Reference Series in Phytochemistry ((RSP))

  • 34 Accesses

Abstract

The inflammatory response is a highly self-regulated process that arises due to the common consequence of injury or infection and it has been observed that chronic inflammations cause tissue damage. The complexity of this process attracted huge scientific interest which deals with understanding inflammatory responses at their molecular level. Generally inflammatory response occurring within the brain and spinal cord is known as neuroinflammation. The severity of neuroinflammation is highly dependent on the type of disease, injury, infection, or stress while the duration and course of neuroinflammatory responses equally contribute to understand these processes and the subsequent physiological, biochemical, and behavioral changes. Neuroinflammatory responses are mediated by microglia which are the innate immune cells of the central nervous system (CNS). Many years of research support the fact that chronic inflammation along with increasing age increases the risk of progressive neurodegenerative diseases. Neuroinflammation and increasing oxidative stress form the basis of neuronal apoptosis ending up with synaptic loss leading to physiological and behavioral changes in the patients. Several natural compounds have been proven to possess a strong antioxidant effect that reduces neuroinflammation in many neurodegenerative diseases. In this review, we present the reports on few natural antioxidants which act against neuroinflammatory disorders while focusing on their molecular mechanism of action.

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Abbreviations

AD:

Alzheimer’s disease

ALS:

Amyotrophic lateral sclerosis

ARE:

Antioxidant response element

HD:

Huntington’s disease

MMP:

Matrix metalloproteinase

MS:

Multiple sclerosis

Nrf2:

Nuclear factor erythroid 2-related factor 2

PD:

Parkinson’s disease

SVD:

Small vessel disease

References

  1. Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140(6):918–934

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Zheng Z, Lee JE, Yenari MA (2003) Stroke: molecular mechanisms and potential targets for treatment. CurrMol Med 3(4):361–372

    CAS  Google Scholar 

  3. Hirsch EC, Hunot S, Hartmann A. Neuroinflammatory processes in Parkinson’s disease. Parkinsonism Relat Disord 2005;11:S9–S15

    Google Scholar 

  4. McGeer EG, McGeer PL (2003) Inflammatory processes in Alzheimer’s disease. Prog Neuro-Psychopharmacol Biol Psychiatry 27(5):741–749

    Article  CAS  Google Scholar 

  5. Gao HM, Hong JS (2008) Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression. Trends Immunol 29(8):357–365

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH (2010) Mechanisms underlying infl ammation in neurodegeneration. Cell 140:918–934

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Philips T, Robberecht W (2011) Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease. Lancet Neurol:10, 253–263. 107

    Google Scholar 

  8. Vlad SC, Miller DR, Kowall NW, Felson DT (2008) Protective effects of NSAIDs on the development of Alzheimer disease. Neurology 70(19):1672–1677

    Article  CAS  PubMed  Google Scholar 

  9. Allison DJ, Ditor DS (2014) The common inflammatory etiology of depression and cognitive impairment: a therapeutic target. J Neuroinflammation 11(1):1–2

    Article  CAS  Google Scholar 

  10. Shimizu M, Ishikawa J, Yano Y, Hoshide S, Shimada K, Kario K (2011) The relationship between the morning blood pressure surge and low-grade inflammation on silent cerebral infarct and clinical stroke events. Atherosclerosis 219(1):316–321

    Article  CAS  PubMed  Google Scholar 

  11. Johnson FA, Dawson AJ, Meyer RL (1999) Activity-dependent refinement in the goldfish retinotectal system is mediated by the dynamic regulation of processes withdrawal: an in vivo imaging study. J Comp Neurol 406(4):548–562

    Article  CAS  PubMed  Google Scholar 

  12. Capuron L, Su S, Miller AH, Bremner JD, Goldberg J, Vogt GJ, Maisano C, Jones L, Murrah NV, Vaccarino V (2008) Depressive symptoms and metabolic syndrome: is inflammation the underlying link? Biol Psychiatry 64(10):896–900

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Whelton A, Watson AJ (1998) Nonsteroidal anti-inflammatory drugs: effects on kidney function. In: Clinical Nephrotoxins. Springer, Dordrecht, pp 203–216

    Chapter  Google Scholar 

  14. DiSabato DJ, Quan N, Godbout JP (2016) Neuroinflammation: the devil is in the details. J Neurochem 139:136–153

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Harms AS, Standaert DG (2014) Monocytes and Parkinson’s disease: invaders from outside? Mov Disord 29(10):1242

    Article  CAS  PubMed  Google Scholar 

  16. Jones KA, Maltby S, Plank MW, Kluge M, Nilsson M, Foster PS, Walker FR (2018) Peripheral immune cells infiltrate into sites of secondary neurodegeneration after ischemic stroke. Brain Behav Immun 67:299–307

    Article  CAS  PubMed  Google Scholar 

  17. Muneer PA, Alikunju S, Szlachetka AM, Haorah J (2012) The mechanisms of cerebral vascular dysfunction and neuroinflammation by MMP-mediated degradation of VEGFR-2 in alcohol ingestion. Arterioscler Thromb Vasc Biol 32(5):1167–1177

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  18. Liu Y, Zhang M, Hao W, Mihaljevic I, Liu X, Xie K, Walter S, Fassbender K (2013) Matrix metalloproteinase-12 contributes to neuroinflammation in the aged brain. Neurobiol Aging 34(4):1231–1239

    Article  PubMed  CAS  Google Scholar 

  19. Vafadari B, Salamian A, Kaczmarek L (2016) MMP-9 in translation: from molecule to brain physiology, pathology, and therapy. J Neurochem 139:91–114

    Article  CAS  PubMed  Google Scholar 

  20. Niranjan R (2013) Molecular basis of etiological implications in Alzheimer’s disease: focus on neuroinflammation. Mol Neurobiol 48(3):412–428

    Article  CAS  PubMed  Google Scholar 

  21. Kumar P, Kumar D, Jha SK, Jha NK, Ambasta RK (2016) Ion channels in neurological disorders. In: Advances in protein chemistry and structural biology, vol 103. Academic Press, Waltham, pp 97–136

    Google Scholar 

  22. Frank-Cannon TC, Alto LT, McAlpine FE, Tansey MG (2009) Does neuroinflammation fan the flame in neurodegenerative diseases? Mol Neurodegener 4(1):47

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  23. Firdaus F, Zafeer MF, Anis E, Ahmad M, Afzal M (2018) Ellagic acid attenuates arsenic -induced neuro-inflammation and mitochondrial dysfunction associated apoptosis. Toxicol Rep 5:411–417

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Gülçin İ (2006) Antioxidant activity of caffeic acid (3, 4-dihydroxycinnamic acid). Toxicology 217(2–3):213–220

    Article  PubMed  CAS  Google Scholar 

  25. Mallik SB, Mudgal J, Nampoothiri M, Hall S, Anoopkumar-Dukie S, Grant G, Rao CM, Arora D (2016) Caffeic acid attenuates lipopolysaccharide – induced sickness behaviour and neuroinflammation in mouse. Neurosci Lett 632:218–223

    Article  CAS  Google Scholar 

  26. Essa MM, Subash S, Akbar M, Al-Adawi S, Guillemin GJ (2015) Long-term dietary supplementation of pomegranates, figs and dates alleviate neuroinflammation in a transgenic mouse model of Alzheimer’s disease. PLoS One 10(3):p.e0120964

    Google Scholar 

  27. Kumar M, Kaur D, Bansal N (2017) Caffeic acid phenethyl ester (CAPE) prevents development of STZ-ICV -induced dementia in rats. Pharmacogn Mag 13(Suppl 1):S10

    PubMed  PubMed Central  Google Scholar 

  28. Morroni F, Sita G, Graziosi A, Turrini E, Fimognari C, Tarozzi A, Hrelia P (2018) Neuroprotective effect of caffeic acid phenethyl ester in a mouse model of Alzheimer’s disease involves Nrf2/HO-1 pathway. Aging Dis 9(4):605

    Article  PubMed  PubMed Central  Google Scholar 

  29. Fontanilla CV, Ma Z, Wei X, Klotsche J, Zhao L, Wisniowski P, Dodel RC, Farlow MR, Oertel WH, Du Y (2011) Caffeic acid phenethyl ester prevents 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine – induced neurodegeneration. Neuroscience 188:135–141

    Article  CAS  PubMed  Google Scholar 

  30. Van Eldik LJ, Carrillo MC, Cole PE, Feuerbach D, Greenberg BD, Hendrix JA, Kennedy M, Kozauer N, Margolin RA, Molinuevo JL, Mueller R (2016) The roles of inflammation and immune mechanisms in Alzheimer’s disease. Alzheimer’s Dement 2(2):99–109

    Article  Google Scholar 

  31. Mancuso C, Santangelo R (2014) Ferulic acid: pharmacological and toxicological aspects. Food Chem Toxicol 65:185–195

    Article  CAS  PubMed  Google Scholar 

  32. Zhao Z, Moghadasian MH (2008) Chemistry, natural sources, dietary intake and pharmacokinetic properties of ferulic acid: a review. Food Chem 109(4):691–702

    Article  CAS  PubMed  Google Scholar 

  33. Smith BG, Harris PJ (2001) Ferulic acid is esterified to glucuronoarabinoxylans in pineapple cell walls. Phytochemistry 56(5):513–519

    Article  CAS  PubMed  Google Scholar 

  34. Barone E, Calabrese V, Mancuso C (2009) Ferulic acid and its therapeutic potential as a hormetin for age-related diseases. Biogerontology 10(2):97–108

    Article  CAS  PubMed  Google Scholar 

  35. Smith MM, Hartley RD (1983) Occurrence and nature of ferulic acid substitution of cell-wall polysaccharides in graminaceous plants. Carbohydr Res 118:65–80

    Article  CAS  Google Scholar 

  36. Nyström L, Mäkinen M, Lampi AM, Piironen V (2005) Antioxidant activity of steryl ferulate extracts from rye and wheat bran. J Agric Food Chem 53(7):2503–2510

    Article  PubMed  CAS  Google Scholar 

  37. Herrmann K, Nagel CW (1989) Occurrence and content of hydroxycinnamic and hydroxybenzoic acid compounds in foods. Crit Rev Food Sci Nutr 28(4):315–347

    Article  CAS  PubMed  Google Scholar 

  38. Schieber A, Keller P, Carle R (2001) Determination of phenolic acids and flavonoids of apple and pear by high-performance liquid chromatography. J Chromatogr A 910(2):265–273

    Article  CAS  PubMed  Google Scholar 

  39. Price KR, Casuscelli F, Colquhoun IJ, Rhodes MJ (1997) Hydroxycinnamic acid esters from broccoli florets. Phytochemistry 45(8):1683–1687

    Article  CAS  Google Scholar 

  40. Plumb GW, Price KR, Modes MJ, Williamson G (1997) Antioxidant properties of the major polyphenolic compounds in broccoli. Free Radic Res 27(4):429–435

    Article  CAS  PubMed  Google Scholar 

  41. Paganga G, Miller N, Rice-Evans CA (1999) The polyphenolic content of fruit and vegetables and their antioxidant activities. What does a serving constitute? Free Radic Res 30(2):153–162

    Article  CAS  PubMed  Google Scholar 

  42. Sakakibara H, Honda Y, Nakagawa S, Ashida H, Kanazawa K (2003) Simultaneous determination of all polyphenols in vegetables, fruits, and teas. J Agric Food Chem 51(3):571–581

    Article  CAS  PubMed  Google Scholar 

  43. Yang SA, Jung YS, Lee SJ, Park SC, Kim MJ, Lee EJ, Byun HJ, Jhee KH, Lee SP (2014) Hepatoprotective effects of fermented field water-dropwort (Oenanthe javanica) extract and its major constituents. Food Chem Toxicol 67:154–160

    Article  CAS  PubMed  Google Scholar 

  44. Kikuzaki H, Hisamoto M, Hirose K, Akiyama K, Taniguchi H (2002) Antioxidant properties of ferulic acid and its related compounds. J Agric Food Chem 50(7):2161–2168

    Article  CAS  PubMed  Google Scholar 

  45. Ou S, Kwok KC (2004) Ferulic acid: pharmaceutical functions, preparation and applications in foods. J Sci Food Agric 84(11):1261–1269

    Article  CAS  Google Scholar 

  46. Calkins MJ, Johnson DA, Townsend JA et al (2009) The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease. Antioxid Redox Signal 11:497–508

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Joshi G, Johnson JA (2012) The Nrf2-ARE pathway: a valuable therapeutic target for the treatment of neurodegenerative diseases. Recent Pat CNS Drug Discov 7(3):218–229

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Huang WY, Chao XJ, Ouyang Y, Liu AM, He XX, Chen MH, Wang LH, Liu J, Yu SW, Rapposelli S, Pi RB (2012) Tacrine-6-ferulic acid, a novel multifunctional dimer against Alzheimer’s disease, prevents oxidative stress-induced neuronal death through activating Nrf2/ARE/HO-1 pathway in HT22 cells. CNS Neurosci Ther 18(11):950

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Kanski J, Aksenova M, Stoyanova A, Butterfield DA (2002) Ferulic acid antioxidant protection against hydroxyl and peroxyl radical oxidation in synaptosomal and neuronal cell culture systems in vitro: structure-activity studies. J Nutr Biochem 13(5):273–281

    Article  CAS  PubMed  Google Scholar 

  50. Yang H, Qu Z, Zhang J, Huo L, Gao J, Gao W (2016) Ferulic acid ameliorates memory impairment in d-galactose – induced aging mouse model. Int J Food Sci Nutr 67(7):806–817

    Article  CAS  PubMed  Google Scholar 

  51. Wenk GL, McGann-Gramling K, Hauss-Wegrzyniak B, Ronchetti D, Maucci R, Rosi S, Gasparini L, Ongini E (2004) Attenuation of chronic neuroinflammation by a nitric oxide-releasing derivative of the antioxidant ferulic acid. J Neurochem 89(2):484–493

    Article  CAS  PubMed  Google Scholar 

  52. Rehman SU, Ali T, Alam SI, Ullah R, Zeb A, Lee KW, Rutten BP, Kim MO (2019) Ferulic acid rescues LPS – induced neurotoxicity via modulation of the TLR4 receptor in the mouse hippocampus. Mol Neurobiol 56(4):2774–2790

    Article  CAS  PubMed  Google Scholar 

  53. Wang H, Sun X, Zhang N, Ji Z, Ma Z, Fu Q, Qu R, Ma S (2017) Ferulic acid attenuates diabetes – induced cognitive impairment in rats via regulation of PTP1B and insulin signaling pathway. Physiol Behav 182:93–100

    Article  CAS  PubMed  Google Scholar 

  54. Ojha S, Javed H, Azimullah S, Khair SB, Haque ME (2015) Neuroprotective potential of ferulic acid in the rotenone model of Parkinson’s disease. Drug Des Devel Ther 9:5499

    CAS  PubMed  PubMed Central  Google Scholar 

  55. Gupta SC, Patchva S, Aggarwal BB (2013) Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J 15(1):195–218

    Article  CAS  PubMed  Google Scholar 

  56. Tiwari V, Chopra K (2013) Protective effect of curcumin against chronic alcohol – induced cognitive deficits and neuroinflammation in the adult rat brain. Neuroscience 244:147–158

    Article  CAS  PubMed  Google Scholar 

  57. Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM (2001) The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 21(21):8370–8377

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Kim DS, Park SY, Kim JY (2001) Curcuminoids from Curcuma longa L.(Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from βA (1–42) insult. Neurosci Lett 303(1):57–61

    Article  CAS  PubMed  Google Scholar 

  59. Baum L, Ng A (2004) Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer’s disease animal models. J Alzheimers Dis 6(4):367–377

    Article  CAS  PubMed  Google Scholar 

  60. Ishrat T, Hoda MN, Khan MB, Yousuf S, Ahmad M, Khan MM, Ahmad A, Islam F (2009) Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer’s type (SDAT). Eur Neuropsychopharmacol 19(9):636–647

    Article  CAS  PubMed  Google Scholar 

  61. Ahmed T, N Setzer W, Fazel Nabavi S, Erdogan Orhan I, Braidy N, Sobarzo-Sanchez E, Mohammad Nabavi S (2016) Insights into effects of ellagic acid on the nervous system: a mini review. Curr Pharm Des 22(10):1350–1360

    Article  CAS  PubMed  Google Scholar 

  62. Farbood Y, Sarkaki A, Dolatshahi M, Mansouri SM, Khodadadi A (2015) Ellagic acid protects the brain against 6-hydroxydopamine -induced neuroinflammation in a rat model of Parkinson’s disease. Basic Clin Neurosci 6(2):83

    PubMed  PubMed Central  Google Scholar 

  63. Sarkaki A, Farbood Y, Dolatshahi M, Mansouri SM, Khodadadi A (2016) Neuroprotective effects of ellagic acid in a rat model of Parkinson’s disease. Acta Med Iran:494–502

    Google Scholar 

  64. Kaur J, Kumar M, Bansal N (2016) Ellagic acid administration reverses colchicine – induced dementia in rats. J Pharm Technol Res Manag 4:31–46

    Article  Google Scholar 

  65. Baluchnejadmojarad T, Rabiee N, Zabihnejad S, Roghani M (2017) Ellagic acid exerts protective effect in intrastriatal 6-hydroxydopamine rat model of Parkinson’s disease: possible involvement of ERβ/Nrf2/HO-1 signaling. Brain Res 1662:23–30

    Article  CAS  PubMed  Google Scholar 

  66. Kiasalari Z, Heydarifard R, Khalili M, Afshin-Majd S, Baluchnejadmojarad T, Zahedi E, Sanaierad A, Roghani M (2017) Ellagic acid ameliorates learning and memory deficits in a rat model of Alzheimer’s disease: an exploration of underlying mechanisms. Psychopharmacology 234(12):1841–1852

    Article  CAS  PubMed  Google Scholar 

  67. Mashhadizadeh S, Farbood Y, Dianat M, Khodadadi A, Sarkaki A (2017) Therapeutic effects of ellagic acid on memory, hippocampus electrophysiology deficits, and elevated TNF-α level in brain due to experimental traumatic brain injury. Iran J Basic Med Sci 20(4):399

    PubMed  PubMed Central  Google Scholar 

  68. Firdaus F, Zafeer MF, Anis E, Ahmad M, Afzal M (2018) Ellagic acid attenuates arsenic -induced neuro-inflammation and mitochondrial dysfunction associated apoptosis. Toxicol Rep 5:411–417

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  69. Ijomone OM, Obi AU (2013) Kolaviron, isolated from Garcinia kola, inhibits acetylcholinesterase activities in the hippocampus and striatum of Wistar rats. Ann Neurosci 20(2):42

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. Akinmoladun AC, Akinrinola BL, Olaleye MT, Farombi EO (2015) Kolaviron, a Garcinia kola biflavonoid complex, protects against ischemia/reperfusion injury: pertinent mechanistic insights from biochemical and physical evaluations in rat brain. Neurochem Res 40(4):777–787

    Article  CAS  PubMed  Google Scholar 

  71. Onasanwo SA, Velagapudi R, El-Bakoush A, Olajide OA (2016) Inhibition of neuroinflammation in BV2 microglia by the biflavonoid kolaviron is dependent on the Nrf2/ARE antioxidant protective mechanism. Mol Cell Biochem 414(1–2):23–36

    Article  CAS  PubMed  Google Scholar 

  72. Farombi EO, Awogbindin IO, Farombi TH, Oladele JO, Izomoh ER, Aladelokun OB, Ezekiel IO, Adebambo OI, Abah VO (2019) Neuroprotective role of kolaviron in striatal redo-inflammation associated with rotenone model of Parkinson’s disease. Neurotoxicology 73:132–141

    Article  CAS  PubMed  Google Scholar 

  73. Ishola IO, Adamson FM, Adeyemi OO (2017) Ameliorative effect of kolaviron, a biflavonoid complex from Garcinia kola seeds against scopolamine – induced memory impairment in rats: role of antioxidant defense system. Metab Brain Dis 32(1):235–245

    Article  CAS  PubMed  Google Scholar 

  74. Omotoso GO, Ukwubile II, Arietarhire L, Sulaimon F, Gbadamosi IT (2018) Kolaviron protects the brain in cuprizone – induced model of experimental multiple sclerosis via enhancement of intrinsic antioxidant mechanisms: possible therapeutic applications. Pathophysiology 25(4):299–306

    Article  CAS  PubMed  Google Scholar 

  75. Farombi EO, Abolaji AO, Farombi TH, Oropo AS, Owoje OA, Awunah MT (2018) Garcinia kola seed biflavonoid fraction (Kolaviron), increases longevity and attenuates rotenone – induced toxicity in Drosophila melanogaster. Pestic Biochem Physiol 145:39–45

    Article  CAS  PubMed  Google Scholar 

  76. Ganeshpurkar A, Saluja AK (2017) The pharmacological potential of rutoside. Saudi Pharm J 25(2):149–164

    Article  PubMed  Google Scholar 

  77. Javed H, Khan MM, Ahmad A, Vaibhav K, Ahmad ME, Khan A, Ashafaq M, Islam F, Siddiqui MS, Safhi MM (2012) Rutoside prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type. Neuroscience 210:340–352

    Article  CAS  PubMed  Google Scholar 

  78. Xu PX, Wang SW, Yu XL, Su YJ, Wang T, Zhou WW, Zhang H, Wang YJ, Liu RT (2014) Rutoside improves spatial memory in Alzheimer’s disease transgenic mouse by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation. Behav Brain Res 264:173–180

    Article  CAS  PubMed  Google Scholar 

  79. Khan MM, Raza SS, Javed H, Ahmad A, Khan A, Islam F, Safhi MM, Islam F (2012) Rutoside protects dopaminergic neurons from oxidative stress in an animal model of Parkinson’s disease. Neurotox Res 22(1):1–5

    Article  PubMed  CAS  Google Scholar 

  80. Nkpaa KW, Onyeso GI (2018) Rutoside attenuates neurobehavioral deficits, oxidative stress, neuro-inflammation and apoptosis in fluoride treated rats. Neurosci Lett 682:92–99

    Article  CAS  PubMed  Google Scholar 

  81. Suganya SN, Sumathi T (2017) Effect of rutoside against a mitochondrial toxin, 3-nitropropionicacid -induced biochemical, behavioral and histological alterations-a pilot study on Huntington’s disease model in rats. Metab Brain Dis 32(2):471–481

    Article  CAS  PubMed  Google Scholar 

  82. Koçancı FG, Aslim B (2017) Neuroprotective effects of rutoside and quercetin flavonoids in glaucium corniculatum methanol and water extracts. Int J Second Metab 4(3, Special Issue 1):85–93

    Article  Google Scholar 

  83. Shakya A, Singh GK, Chatterjee SS, Kumar V (2014) Role of fumaric acid in anti-inflammatory and analgesic activities of a Fumaria indica extracts. J Intercult Ethnopharmacol 3(4):173

    Article  PubMed  PubMed Central  Google Scholar 

  84. Gill AJ, Kolson DL (2013) Dimethyl fumarate modulation of immune and antioxidant responses: application to HIV therapy. Crit Rev Immunol 33(4):57

    Article  Google Scholar 

  85. Bjelobaba I, Savic D, Lavrnja I (2017) Multiple sclerosis and neuroinflammation: the overview of current and prospective therapies. Curr Pharm Des 23(5):693–730

    Article  CAS  PubMed  Google Scholar 

  86. Linker RA, Lee DH, Ryan S, van Dam AM, Conrad R, Bista P, Zeng W, Hronowsky X, Buko A, Chollate S, Ellrichmann G (2011) Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134(3):678–692

    Article  PubMed  Google Scholar 

  87. Lee DH, Gold R, Linker RA (2012) Mechanisms of oxidative damage in multiple sclerosis and neurodegenerative diseases: therapeutic modulation via fumaric acid esters. Int J Mol Sci 13(9):11783–11803

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Ahuja M, Kaidery NA, Yang L, Calingasan N, Smirnova N, Gaisin A, Gaisina IN, Gazaryan I, Hushpulian DM, Kaddour-Djebbar I, Bollag WB (2016) Distinct Nrf2 signaling mechanisms of fumaric acid esters and their role in neuroprotection against 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine – induced experimental Parkinson’s-like disease. J Neurosci 36(23):6332–6351

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Ellrichmann G, Petrasch-Parwez E, Lee DH, Reick C, Arning L, Saft C, Gold R, Linker RA (2011) Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington’s disease. PLoS One 6(1):e16172

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  90. Majkutewicz I, Kurowska E, Podlacha M, Myślińska D, Grembecka B, Ruciński J, Plucińska K, Jerzemowska G, Wrona D (2016) Dimethyl fumarate attenuates intracerebroventricular streptozotocin – induced spatial memory impairment and hippocampal neurodegeneration in rats. Behav Brain Res 308:24–37

    Article  CAS  PubMed  Google Scholar 

  91. Pegg AE (2016) Functions of polyamines in mammals. J Biol Chem 291(29):14904–14912

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  92. Thangarajan S, Deivasigamani A, Natarajan SS, Krishnan P, Mohanan SK (2014) Neuroprotective activity of L-theanine on 3-nitropropionic acid – induced neurotoxicity in rat striatum. Int J Neurosci 124(9):673–684

    Article  CAS  PubMed  Google Scholar 

  93. Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, Adame A, Muhammad A, Vonsattel JP, Ringe D, Cote L (2010) Polyamine pathway contributes to the pathogenesis of Parkinson disease. Proc Natl Acad Sci 107(39):16970–16975

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  94. Minois N, Carmona-Gutierrez D, Madeo F (2011) Polyamines in aging and disease. Aging (Albany NY) 3(8):716

    Article  Google Scholar 

  95. Madeo F, Eisenberg T, Pietrocola F, Kroemer G (2018) Spermidine in health and disease. Science 359(6374):eaan2788

    Google Scholar 

  96. Jamwal S, Singh S, Kaur N, Kumar P (2015) Protective effect of spermidine against excitotoxic neuronal death -induced by quinolinic acid in rats: possible neurotransmitters and neuroinflammatory mechanism. Neurotox Res 28(2):171–184

    Article  CAS  PubMed  Google Scholar 

  97. Jamwal S, Kumar P (2016) Spermidine ameliorates 3-nitropropionic acid (3-NP) – induced striatal toxicity: possible role of oxidative stress, neuroinflammation, and neurotransmitters. Physiol Behav 155:180–187

    Article  CAS  PubMed  Google Scholar 

  98. Laube G, Veh RW (1997) Astrocytes, not neurons, show most prominent staining for spermidine/spermine-like immunoreactivity in adult rat brain. Glia 19:171–179

    Article  CAS  PubMed  Google Scholar 

  99. Biedermann B, Skatchkov SN, Bringmann A et al (1998) Spermine/spermidine is expressed by retinal glial (Müller) cells, and controls distinct K+ channels of their membrane. Glia 23:209–220

    Article  CAS  PubMed  Google Scholar 

  100. Harada T, Harada C, Nakamura K et al (2007) The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma. J Clin Investig 117:1763–1770

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  101. Noro T, Namekata K, Azuchi Y, Kimura A, Guo X, Harada C, Nakano T, Tsuneoka H, Harada T (2015) Spermidine ameliorates neurodegeneration in a mouse model of normal tension glaucoma. Invest Ophthalmol Vis Sci 56(8):5012–5019

    Article  CAS  PubMed  Google Scholar 

  102. Sharma S, Kumar P, Deshmukh R (2018) Neuroprotective potential of spermidine against rotenone -induced Parkinson’s disease in rats. Neurochem Int 116:104–111

    Article  CAS  PubMed  Google Scholar 

  103. Guo X, Harada C, Namekata K, Kimura A, Mitamura Y, Yoshida H, Matsumoto Y, Harada T (2011) Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis. Invest Ophthalmol Vis Sci 52(5):2696–2703

    Article  CAS  PubMed  Google Scholar 

  104. Meeran MN, Al Taee H, Azimullah S, Tariq S, Adeghate E, Ojha S (2019) β-Caryophyllene, a natural bicyclic sesquiterpene attenuates doxorubicin – induced chronic cardiotoxicity via activation of myocardial cannabinoid type-2 (CB2) receptors in rats. Chem Biol Interact 304:158–167

    Article  CAS  PubMed  Google Scholar 

  105. Francomano F, Caruso A, Barbarossa A, Fazio A, La Torre C, Ceramella J, Mallamaci R, Saturnino C, Iacopetta D, Sinicropi MS (2019) β-Caryophyllene: a Sesquiterpene with countless biological properties. Appl Sci 9(24):5420

    Article  CAS  Google Scholar 

  106. Assis LC, Straliotto MR, Engel D, Hort MA, Dutra RC, De Bem AF (2014) β-Caryophyllene protects the C6 glioma cells against glutamate – induced excitotoxicity through the Nrf2 pathway. Neuroscience 279:220–231

    Article  CAS  PubMed  Google Scholar 

  107. Alberti TB, Barbosa WL, Vieira JL, Raposo NR, Dutra RC (2017) (−)-β-Caryophyllene, a CB2 receptor-selective phytocannabinoid, suppresses motor paralysis and neuroinflammation in a murine model of multiple sclerosis. Int J Mol Sci 18(4):691

    Article  PubMed Central  CAS  Google Scholar 

  108. Viveros-Paredes JM, González-Castañeda RE, Gertsch J, Chaparro-Huerta V, López-Roa RI, Vázquez-Valls E, Beas-Zarate C, Camins-Espuny A, Flores-Soto ME (2017) Neuroprotective effects of β-caryophyllene against dopaminergic neuron injury in a murine model of Parkinson’s disease -induced by MPTP. Pharmaceuticals 10(3):60

    Article  PubMed Central  CAS  Google Scholar 

  109. Chan WK, Tan LT, Chan KG, Lee LH, Goh BH (2016) Nerolidol: a sesquiterpene alcohol with multi-faceted pharmacological and biological activities. Molecules 21(5):529

    Article  PubMed Central  CAS  Google Scholar 

  110. Javed H, Azimullah S, Khair SB, Ojha S, Haque ME (2016) Neuroprotective effect of nerolidol against neuroinflammation and oxidative stress -induced by rotenone. BMC Neurosci 17(1):58

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  111. Kwon YJ, Son DH, Chung TH, Lee YJ (2020) A review of the pharmacological efficacy and safety of licorice root from corroborative clinical trial findings. J Med Food 23(1):12–20

    Article  CAS  PubMed  Google Scholar 

  112. Ojha S, Javed H, Azimullah S, Khair SB, Haque ME (2016) Glycyrrhizic acid attenuates neuroinflammation and oxidative stress in rotenone model of Parkinson’s disease. Neurotox Res 29(2):275–287

    Article  CAS  PubMed  Google Scholar 

  113. Guo J, Yang C, Yang J, Yao Y (2016) Glycyrrhizic acid ameliorates cognitive impairment in a rat model of vascular dementia associated with oxidative damage and inhibition of voltage-gated sodium channels. CNS Neurol Disord Drug Targets (Formerly Current Drug Targets-CNS & Neurological Disorders) 15(8):1001–1008

    CAS  Google Scholar 

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Acknowledgments

The authors wish to acknowledge the grant provided by DST-FIST (Grant No. SR/FST/LSI-639/2015(C)), UGC-SAP (Grant No.F.5-1/2018/DRS-II (SAP-II)), and RUSA 2.0 [F. 24-51/2014-U, Policy (TN Multi-Gen), Dept. of Education, Government of India].

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  1. Department of Biotechnology, Alagappa University [Science Campus], Karaikudi, India

    Mamali Das & Kasi Pandima Devi

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  1. Mamali Das
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  2. Kasi Pandima Devi
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Correspondence to Kasi Pandima Devi .

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  1. Department of Pharmaceutical Botany, Jagiellonian University, Medical College, Kraków, Poland

    Halina Maria Ekiert

  2. Department of Botany, Mohanlal Sukhadia University, Udaipur, India

    Kishan Gopal Ramawat

  3. Department of Botany, Mohanlal Sukhadia University, Udaipur, India

    Jaya Arora

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  1. Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University, Medical College, Kraków, Poland

    Halina Ekiert

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Das, M., Pandima Devi, K. (2021). The Beneficial Role of Natural Antioxidants in Alleviating Neuroinflammatory Disorders Including Neurodegeneration. In: Ekiert, H.M., Ramawat, K.G., Arora, J. (eds) Plant Antioxidants and Health. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-030-45299-5_31-1

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  • DOI: https://doi.org/10.1007/978-3-030-45299-5_31-1

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  • Print ISBN: 978-3-030-45299-5

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  1. Latest

    The Beneficial Role of Natural Antioxidants in Alleviating Neuroinflammatory Disorders Including Neurodegeneration
    Published:
    27 December 2020

    DOI: https://doi.org/10.1007/978-3-030-45299-5_31-2

  2. Original

    The Beneficial Role of Natural Antioxidants in Alleviating Neuroinflammatory Disorders Including Neurodegeneration
    Published:
    12 December 2020

    DOI: https://doi.org/10.1007/978-3-030-45299-5_31-1

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