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Anxiety Disorder in Youth: Separation Anxiety, Social Anxiety, and Generalized Anxiety Disorders

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Tasman’s Psychiatry

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Abstract

Anxiety disorders are high prevalence, prepubertal onset conditions that can become persistently impairing without adequate treatment. They are among the most common disorders in children, commonly co-occur with other anxiety disorders, and increase the risk of developing secondary disorders (e.g., major depressive disorder). In children and adolescents, a range of developmental, genetic, cognitive, neurobiological, social, and environmental factors contribute to their onset and course. Multimethod, multi-informant assessment is recommended for making an accurate diagnosis and measuring symptoms. Combined treatment with cognitive behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs) produces the greatest improvement, particularly when exposure-based treatment and family involvement are optimized. Children who receive timely diagnosis and treatment of anxiety disorders and achieve symptom remission have better long-term outcomes than those who do not. Hence it is recommended that children are screened for pediatric anxiety disorders, and combined treatment is prioritized with attention to the quality implementation of CBT and medication treatment.

This chapter is an update from the 4th edition. Previous edition authors were Megan E. Hughes-Feltenberger, Justin Mohatt, Shannon M. Bennett and John T. Walkup

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References

  • World Health Organization. (2019). ICD-11: International classification of diseases (11th revision). Retrieved from https://icd.who.int/

  • Barlow, D. H. (2000). Unraveling the mysteries of anxiety and its disorders from the perspective of emotion theory. The American Psychologist, 55(11), 1247–1263. https://doi.org/10.1037//0003-066x.55.11.1247

    Article  CAS  PubMed  Google Scholar 

  • Beesdo, K., Pine, D. S., Lieb, R., & Wittchen, H.-U. (2010). Incidence and risk patterns of anxiety and depressive disorders and categorization of generalized anxiety disorder. Archives of General Psychiatry, 67(1), 47–57. https://doi.org/10.1001/archgenpsychiatry.2009.177

    Article  PubMed  Google Scholar 

  • Beesdo-Baum, K., & Knappe, S. (2012). Developmental epidemiology of anxiety disorders. Child and Adolescent Psychiatric Clinics of North America, 21, 457–478. https://doi.org/10.1016/j.chc.2012.05.001

    Article  PubMed  Google Scholar 

  • Beidel, D. C., Turner, S. M., & Morris, T. L. (1995). A new inventory to assess childhood social anxiety and phobia: The social phobia and anxiety inventory for children. Psychological Assessment, 7(1), 73–79. https://doi.org/10.1037/1040-3590.7.1.73

    Article  Google Scholar 

  • Beidel, D. C., Turner, S. M., Sallee, F. R., Ammerman, R. T., Crosby, L. A., & Pathak, S. (2007). SET-C versus fluoxetine in the treatment of childhood social phobia. Journal of the American Academy of Child and Adolescent Psychiatry, 46(12), 1622–1632. https://doi.org/10.1097/chi.0b013e318154bb57

    Article  PubMed  Google Scholar 

  • Benjamin, C. L., Harrison, J. P., Settipani, C. A., Brodman, D. M., Kendall, P. C. (2013). Anxiety and related outcomes in young adults 7 to 19 years after receiving treatment for child anxiety. J Consult Clin Psychol, 81(5), 865–76

    Google Scholar 

  • Bernstein, G. A., Borchardt, C. M., Perwien, A. R., Crosby, R. D., Kushner, M. G., & Thuras, P. D. (2002). Imipramine plus cognitive-behavioral therapy for school refusal. Journal of the American Academy of Child & Adolescent Psychiatry, 41(2), 111–112. https://doi.org/10.1097/00004583-200202000-00002

    Article  Google Scholar 

  • Birmaher, B., Axelson, D. A., Monk, K., Kalas, C., Clark, D. B., Ehmann, M., Bridge, J., Heo, J., & Brent, D. A. (2003). Fluoxetine for the treatment of childhood anxiety disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 42(4), 415–423. https://doi.org/10.1097/01.CHI.0000037049.04952.9F

    Article  PubMed  Google Scholar 

  • Birmaher, B., Khetarpal, S., Brent, D., Cully, M., Balach, L., Kaufman, J., & Neer, S. M. (1997). The Screen for Child Anxiety-Related Emotional Disorders (SCARED): Scale construction and psychometric characteristics. Journal of the American Academy of Child and Adolescent Psychiatry, 36(4), 545–553. https://doi.org/10.1097/00004583-199704000-00018

    Article  CAS  PubMed  Google Scholar 

  • Brokamp, C., Strawn, J. R., Beck, A. F., & Ryan, P. (2019). Pediatric psychiatric emergency department utilization and fine particulate matter: A case-crossover study. Environmental Health Perspectives, 127(9), 1–7.

    Article  Google Scholar 

  • Brunst, K. J., Ryan, P. H., Altaye, M., Yolton, K., Maloney, T., Beckwith, T., LeMasters, G., & Cecil, K. M. (2019). Myo-inositol mediates the effects of traffic-related air pollution on generalized anxiety symptoms at age 12 years. Environmental Research, 175, 71. https://doi.org/10.1016/j.envres.2019.05.009

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bushnell, G. A., Compton, S. N., Dusetzina, S. B., Gaynes, B. N., Brookhart, M. A., Walkup, J. T., Rynn, M. A., & Sturmer, T. (2018). Treating pediatric anxiety: Initial use of SSRIs and other antianxiety prescription medications. The Journal of Clinical Psychiatry, 79, 16m11415. https://doi.org/10.4088/JCP.16m11415

    Article  PubMed  PubMed Central  Google Scholar 

  • Caporino, N. E., Brodman, D. M., Kendall, P. C., Albano, A. M., Sherrill, J., Piacentini, J., Sakolsky, D., Birmaher, B., Compton, S. N., Ginsburg, G., Rynn, M., McCracken, J., Gosch, E., Keeton, C., March, J., & Walkup, J. T. (2013). Defining treatment response and remission in child anxiety: Signal detection analysis using the pediatric anxiety rating scale. Journal of the American Academy of Child and Adolescent Psychiatry, 52(1), 57–67. https://doi.org/10.1016/j.jaac.2012.10.006

    Article  PubMed  Google Scholar 

  • Clark, D. B., Birmaher, B., Axelson, D., Monk, K., Kalas, C., Ehmann, M., Bridge, J., Wood, D. S., Muthen, B., & Brent, D. (2005). Fluoxetine for the treatment of childhood anxiety disorders: Open-label, long-term extension to a controlled trial. Journal of the American Academy of Child & Adolescent Psychiatry, 44(12), 1263–1270. https://doi.org/10.1097/01.chi.0000183464.41777.c1

    Article  Google Scholar 

  • Compton, S. N., Walkup, J. T., Albano, A. M., Piacentini, J. C., Birmaher, B., Sherrill, J. T., Ginsburg, G. S., Rynn, M. A., McCracken, J. T., Waslick, B. D., Iyengar, S., Kendall, P. C., & March, J. S. (2010). Child/Adolescent Anxiety Multimodal Study (CAMS): rationale, design, and methods. Child Adolesc Psychiatry Ment Health, 4, 1.

    Google Scholar 

  • Compton, S. N., Peris, T. S., Almirall, D., Birmaher, B., Sherrill, J., Kendall, P. C., March, J. S., Gosch, E. A., Ginsburg, G. S., Rynn, M. A., Piacentini, J. C., McCracken, J. T., Keeton, C. P., Suveg, C. M., Aschenbrand, S. G., Sakolsky, D., Iyengar, S., Walkup, J. T., & Albano, A. M. (2014). Predictors and moderators of treatment response in childhood anxiety disorders: Results from the CAMS trial. Journal of Consulting and Clinical Psychology, 82(2), 212–224. https://doi.org/10.1037/a0035458

    Article  PubMed  PubMed Central  Google Scholar 

  • Cummings, C. M., Caporino, N. E., & Kendall, P. C. (2014). Comorbidity of anxiety and depression in children and adolescents: 20 years after. Psychol Bull, 140(3), 816–45.

    Google Scholar 

  • Dobson, E. T., Bloch, M. H., & Strawn, J. R. (2019). Efficacy and tolerability of pharmacotherapy in pediatric anxiety disorders: A network meta-analysis. Journal of Clinical Psychiatry, 80(1), 17r12064.

    PubMed  Google Scholar 

  • Ehrenreich-May, J., Rosenfield, D., Queen, A. H., Kennedy, S. M., Remmes, C. S., & Barlow, D. H. (2017). An initial waitlist-controlled trial of the unified protocol for the treatment of emotional disorders in adolescents. Journal of Anxiety Disorders, 46, 46–55. https://doi.org/10.1016/j.janxdis.2016.10.006

    Article  PubMed  Google Scholar 

  • Ellis, H. H., Fisher, P. A., & Zaharie, S. (2004). Predictors of disruptive behavior, developmental delays, anxiety, and affective symptomatology among institutionally reared Romanian children. Journal of the American Academy of Child and Adolescent Psychiatry, 43, 1283. https://doi.org/10.1097/01.chi.0000136562.24085.160

    Article  PubMed  Google Scholar 

  • Fluvoxamine for the treatment of anxiety disorders in children and adolescents. The Research Unit on Pediatric Psychopharmacology Anxiety Study Group. (2001). N. The New England Journal of Medicine, 344(17), 1279–1285. https://doi.org/10.1056/nejm200104263441703

    Article  Google Scholar 

  • Fox, N. A., Buzzell, G. A., Morales, S., Valadez, E. A., Wilson, M., & Henderson, H. A. (2021). Understanding the Emergence of Social Anxiety in Children With Behavioral Inhibition. Biological Psychiatry, 89(7), 681–689. https://doi.org/10.1016/j.biopsych.2020.10.004

    Article  PubMed  Google Scholar 

  • Gearing, R. E., Schwalbe, C. S., Lee, R., Hoagwood, K. E. (2013). The effectiveness of booster sessions in CBT treatment for child and adolescent mood and anxiety disorders. Depress Anxiety, 30(9), 800–8

    Google Scholar 

  • Gee, D. G., Gabard-Durnam, L. J., Flannery, J., Goff, B., Humphreys, K. L., Telzer, E. H., Hare, T. A., Bookheimer, S. Y., & Tottenham, N. (2013). Early developmental emergence of human amygdala-prefrontal connectivity after maternal deprivation. Proceedings of the National Academy of Sciences, 110, 15638. https://doi.org/10.1073/pnas.1307893110

    Article  Google Scholar 

  • Geller, D., Donnelly, C., Lopez, F., Rubin, R., Newcorn, J., Sutton, V., Bakken, R., Paczkowski, M., Kelsey, D., & Sumner, C. (2007). Atomoxetine treatment for pediatric patients with attention-deficit/hyperactivity disorder with comorbid anxiety disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 46(9), 1119–1127. https://doi.org/10.1097/chi.0b013e3180ca8385

    Article  PubMed  Google Scholar 

  • Ginsburg, G. S., Becker-Haimes, E. M., Keeton, C., Kendall, P. C., Iyengar, S., Sakolsky, D., Albano, A. M., Peris, T., Compton, S. N., & Piacentini, J. (2018). Results from the child/adolescent anxiety multimodal extended long-term study (CAMELS): Primary anxiety outcomes. Journal of the American Academy of Child and Adolescent Psychiatry. https://doi.org/10.1016/j.jaac.2018.03.017

  • Ginsburg, G. S., Kendall, P. C., Sakolsky, D., Compton, S. N., Piacentini, J., Albano, A. M., Walkup, J. T., Sherrill, J., Coffey, K. A., Rynn, M. A., Keeton, C. P., McCracken, J. T., Bergman, L., Iyengar, S., Birmaher, B., & March, J. (2011). Remission after acute treatment in children and adolescents with anxiety disorders: Findings from the CAMS. Journal of Consulting and Clinical Psychology, 79(6), 806–813. https://doi.org/10.1037/a0025933

    Article  PubMed  PubMed Central  Google Scholar 

  • Hathaway, E. E., Walkup, J. T., & Strawn, J. R. (2017). Antidepressant treatment duration in pediatric depressive and anxiety disorders: How long is long enough? Current Problems in Pediatric and Adolescent Health Care, 48(2), 31–39. https://doi.org/10.1016/j.cppeds.2017.12.002

    Article  Google Scholar 

  • Humphreys, K. L., Gleason, M. M., Drury, S. S., Miron, D., Nelson, C. A., Fox, N. A., & Zeanah, C. H. (2015). Effects of institutional rearing and foster care on psychopathology at age 12 years in Romania: Follow-up of an open, randomised controlled trial. The Lancet Psychiatry, 2, 625. https://doi.org/10.1016/S2215-0366(15)00095-4

    Article  PubMed  PubMed Central  Google Scholar 

  • Kessler, R. C., Avenevoli, S., Costello, J., Green, J. G., Gruber, M. J., McLaughlin, K. A., Petukhova, M., Sampson, N. A., Zaslavsky, A. M., & Merikangas, K. R. (2012). Severity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication Adolescent Supplement. Archives of General Psychiatry, 69(4), 381–389. https://doi.org/10.1001/archgenpsychiatry.2011.1603

    Article  PubMed  PubMed Central  Google Scholar 

  • Kuang, H., Johnson, J. A., Mulqueen, J. M., & Bloch, M. H. (2017). The efficacy of benzodiazepines as acute anxiolytics in children: A meta-analysis. Depression and Anxiety, 34, 888. https://doi.org/10.1002/da.22643

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lau, J. Y. F., & Waters, A. M. (2017). Annual research review: An expanded account of information-processing mechanisms in risk for child and adolescent anxiety and depression. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 58(4), 387–407. https://doi.org/10.1111/jcpp.12653

    Article  PubMed  Google Scholar 

  • Lebowitz, E. R., Woolston, J., Bar-Haim, Y., Calvocoressi, L., Dauser, C., Warnick, E., Scahill, L., Chakir, A. R., Shechner, T., Hermes, H., Vitulano, L. A., King, R. A., & Leckman, J. F. (2013). Family accommodation in pediatric anxiety disorders. Depression and Anxiety, 30(1), 47–54. https://doi.org/10.1002/da.21998

    Article  PubMed  Google Scholar 

  • Lewis-Morrarty, E., Degnan, K. A., Chronis-Tuscano, A., Pine, D. S., Henderson, H. A., & Fox, N. A. (2015). Infant Attachment Security and Early Childhood Behavioral Inhibition Interact to Predict Adolescent Social Anxiety Symptoms. Child Development, 86, 598. https://doi.org/10.1111/cdev.12336

    Article  PubMed  Google Scholar 

  • Locher, C., Koechlin, H., Zion, S. R., Werner, C., Pine, D. S., Kirsch, I., Kessler, R. C., & Kossowsky, J. (2017). Efficacy and safety of selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and placebo in common psychiatric disorders a meta-analysis in children and adolescents. JAMA Psychiatry, 74(10), 1011–1020. https://doi.org/10.1001/jamapsychiatry.2017.2432

    Article  PubMed  PubMed Central  Google Scholar 

  • Lu, L., Mills, J. A., Li, H., Schroeder, H. K., Mossman, S. A., Varney, S. T., Cecil, K. M., Huang, X., Gong, Q., Ramsey, L. B., DelBello, M. P., Sweeney, J. A., & Strawn, J. R. (2021). Acute neurofunctional effects of escitalopram in pediatric anxiety: A double-blind, placebo-controlled trial. Journal of the American Academy of Child and Adolescent Psychiatry. https://doi.org/10.1016/j.jaac.2020.11.023

  • March, J. S., Parker, J. D., Sullivan, K., Stallings, P., & Conners, C. K. (1997). The Multidimensional Anxiety Scale for Children (MASC): Factor structure, reliability, and validity. Journal of the American Academy of Child and Adolescent Psychiatry, 36(4), 554–565. https://doi.org/10.1097/00004583-199704000-00019

    Article  CAS  PubMed  Google Scholar 

  • McClure, E. B., Monk, C. S., Nelson, E. E., Parrish, J. M., Adler, A., Blair, R. J. R., Fromm, S., Charney, D. S., Leibenluft, E., Ernst, M., & Pine, D. S. (2007). Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder. Archives of General Psychiatry, 64(1), 97–106. https://doi.org/10.1001/archpsyc.64.1.97

    Article  PubMed  Google Scholar 

  • Merikangas, K. R., He, J., Burstein, M., Swendsen, J., Avenevoli, S., Case, B., Georgiades, K., Heaton, L., Swanson, S., & Olfson, M. (2011). Service utilization for lifetime mental disorders in U.S. adolescents: Results of the National Comorbidity Survey-Adolescent Supplement (NCS-A). Journal of the American Academy of Child and Adolescent Psychiatry, 50(1), 32–45. https://doi.org/10.1016/j.jaac.2010.10.006

    Article  PubMed  Google Scholar 

  • Mills, J. A., & Strawn, J. R. (2020). Antidepressant tolerability in pediatric anxiety and obsessive-compulsive disorders: A bayesian hierarchical modeling meta-analysis. Journal of the American Academy of Child and Adolescent Psychiatry, 59(11), 1240–1251. https://doi.org/10.1016/j.jaac.2019.10.013

    Article  PubMed  Google Scholar 

  • Monk, C. S., Nelson, E. E., McClure, E. B., Mogg, K., Bradley, B. P., Leibenluft, E., Blair, R. J. R., Chen, G., Charney, D. S., Ernst, M., & Pine, D. S. (2006). Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder. American Journal of Psychiatry, 163(6), 1091–1097. https://doi.org/10.1176/appi.ajp.163.6.1091

    Article  PubMed  Google Scholar 

  • Monk, C. S., Telzer, E. H., Mogg, K., Bradley, B. P., Mai, X., Louro, H. M. C., Chen, G., McClure-Tone, E. B., Ernst, M., & Pine, D. S. (2008). Amygdala and ventrolateral prefrontal cortex activation to masked angry faces in children and adolescents with generalized anxiety disorder. Archives of General Psychiatry, 65(5), 568–576. https://doi.org/10.1016/S0084-3970(08)79329-0

    Article  PubMed  PubMed Central  Google Scholar 

  • Mossman, S. A., Luft, M. J., Schroeder, H. K., Varney, S. T., Fleck, D. E., Barzman, D. H., Gilman, R., DelBello, M. P., & Strawn, J. R. (2017). The generalized anxiety disorder 7-item scale in adolescents with generalized anxiety disorder: Signal detection and validation. Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists, 29(4), 227–234A.

    PubMed  Google Scholar 

  • O’Neil, K. A., Puleo, C. M., Benjamin, C. L., Podell, J. L., & Kendall, P. C. (2012). Suicidal ideation in anxiety-disordered youth. Suicide Life Threat Behav, 42(3), 305–17.

    Google Scholar 

  • Patel, N. B., Xu, Y., McCandless, L. C., Chen, A., Yolton, K., Braun, J., Jones, R. L., Dietrich, K. N., & Lanphear, B. P. (2019). Very low-level prenatal mercury exposure and behaviors in children: The HOME Study. Environmental Health: A Global Access Science Source, 18, 1. https://doi.org/10.1186/s12940-018-0443-5

    Article  Google Scholar 

  • Piacentini, J., Bennett, S., Compton, S. N., Kendall, P. C., Birmaher, B., Albano, A. M., March, J., Sherrill, J., Sakolsky, D., Ginsburg, G., Rynn, M., Bergman, R. L., Gosch, E., Waslick, B., Iyengar, S., McCracken, J., & Walkup, J. (2014). 24- and 36-week outcomes for the child/adolescent anxiety multimodal study (CAMS). Journal of the American Academy of Child and Adolescent Psychiatry, 53(3), 297–310. https://doi.org/10.1016/j.jaac.2013.11.010

    Article  PubMed  Google Scholar 

  • Rifkin, A., & Braga, R. J. (2009). Behavioral therapy, sertraline, or both in childhood anxiety. New England Journal of Medicine, 360(23), 2475–2477. https://doi.org/10.1056/NEJMc090139

    Article  CAS  PubMed  Google Scholar 

  • Rynn, M. A., Siqueland, L., & Rickels, K. (2001). Placebo-controlled trial of sertraline in the treatment of children with generalized anxiety disorder. The American Journal of Psychiatry, 158(12), 2008–2014. http://www.ncbi.nlm.nih.gov/pubmed/11729017

    Article  CAS  PubMed  Google Scholar 

  • Rynn, M. A., Walkup, J. T., Compton, S. N., Sakolsky, D. J., Sherrill, J. T., Shen, S., Kendall, P. C., McCracken, J., Albano, A. M., Piacentini, J., Riddle, M. A., Keeton, C., Waslick, B., Chrisman, A., Iyengar, S., March, J. S., & Birmaher, B. (2015). Child/Adolescent anxiety multimodal study: Evaluating safety. Journal of the American Academy of Child and Adolescent Psychiatry, 54(3), 180–190. https://doi.org/10.1016/j.jaac.2014.12.015

    Article  PubMed  Google Scholar 

  • Saavedra, L. M., Silverman, W. K., Morgan-Lopez, A. A., Kurtines, W. M. (2010). Cognitive behavioral treatment for childhood anxiety disorders: long-term effects on anxiety and secondary disorders in young adulthood. J Child Psychol Psychiatry, 51(8), 924–34

    Google Scholar 

  • Sakolsky, D. J., McCracken, J. T., & Nurmi, E. L. (2012). Genetics of pediatric anxiety disorders. Child and Adolescent Psychiatric Clinics of North America, 21, 479–500. https://doi.org/10.1016/j.chc.2012.05.010

    Article  PubMed  Google Scholar 

  • Seligman, L. D., & Ollendick, T. H. (2011). Cognitive-Behavioral Therapy for Anxiety Disorders in Youth. Child and Adolescent Psychiatric Clinics of North America, 20, 217. https://doi.org/10.1016/j.chc.2011.01.003

    Article  PubMed  PubMed Central  Google Scholar 

  • Silverman, W. K., Pina, A. A., & Viswesvaran, C. (2008). Evidence-based psychosocial treatments for phobic and anxiety disorders in children and adolescents. Journal of Clinical Child and Adolescent Psychology, 37, 105. https://doi.org/10.1080/15374410701817907

    Article  PubMed  Google Scholar 

  • Spence, S. H. (1998). A measure of anxiety symptoms among children. Behaviour Research and Therapy, 36(5), 545–566. S0005-7967(98)00034-5 [pii]

    Article  CAS  PubMed  Google Scholar 

  • Strawn, J., Mills, J., Schroeder, H., Mossman, S., Varney, S., Ramsey, L., Poweleit, E., Desta, Z., Cecil, K., & DelBello, M. (2020a). Escitalopram in adolescents with generalized anxiety disorder: A double-blind, randomized, placebo-controlled study. The Journal of Clinical Psychiatry. ePub Ahead.

    Google Scholar 

  • Strawn, J. R., Prakash, A., Zhang, Q., Pangallo, B. A., Stroud, C. E., Cai, N., & Findling, R. L. (2016). A randomized, placebo-controlled study of extended-release guanfacine for the treatment of children and adolescents with generalized, separation or social anxiety disorder. Anxiety and Depressive Disorders Association of America.

    Google Scholar 

  • Strawn, J. R., Dobson, E. T., Mills, J. A., Cornwall, G. J., Sakolsky, D., Birmaher, B., Compton, S. N., Piacentini, J., McCracken, J. T., Ginsburg, G. S., Kendall, P. C., Walkup, J. T., Albano, A. M., & Rynn, M. A. (2017a). Placebo response in pediatric anxiety disorders: Results from the child/adolescent anxiety multimodal study. Journal of Child and Adolescent Psychopharmacology, 27(6), 501–508.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Strawn, J. R., Dominick, K. C., Patino, L. R., Doyle, C. D., Picard, L. S., & Phan, K. L. (2014). Neurobiology of pediatric anxiety disorders. Current Behavioral Neuroscience Reports, 1(3), 154–160. https://doi.org/10.1007/s40473-014-0014-1

    Article  PubMed  PubMed Central  Google Scholar 

  • Strawn, J. R., Bitter, S. M., Weber, W. A., Chu, W.-J., Whitsel, R. M., Adler, C., Cerullo, M. A., Eliassen, J., Strakowski, S. M., & Delbello, M. P. (2012). Neurocircuitry of generalized anxiety disorder in adolescents: A pilot functional neuroimaging and functional connectivity study. Depression and Anxiety, 29(11), 939–947. https://doi.org/10.1002/da.21961

    Article  PubMed  Google Scholar 

  • Strawn, J. R., Mills, J. A., Cornwall, G. J., Mossman, S. A., Varney, S. T., Keeshin, B. R., & Croarkin, P. E. (2017b). Buspirone in children and adolescents with anxiety: A review and Bayesian analysis of abandoned randomized controlled trials. Journal of Child and Adolescent Psychopharmacology, 28(1), cap.2017.0060. https://doi.org/10.1089/cap.2017.0060

    Article  CAS  Google Scholar 

  • Strawn, J. R., Lu, L., Peris, T. S., Levine, A., & Walkup, J. T. (2020b). Research review: Peadiatric anxiety disorders: What have we learnt in the last 10 years? Journal of Child Psychology and Psychiatry, 62, 114. https://doi.org/10.1111/JCPP.13262

    Article  PubMed  Google Scholar 

  • Strawn, J. R., Mills, J. A., Sauley, B. A., & Welge, J. A. (2018). The Impact of Antidepressant Dose and Class on Treatment Response in Pediatric Anxiety Disorders: A Meta-Analysis. Journal of the American Academy of Child and Adolescent Psychiatry, 57(4), 235. https://doi.org/10.1016/j.jaac.2018.01.015

    Article  PubMed  PubMed Central  Google Scholar 

  • Strawn, J. R., Prakash, A., Zhang, Q., Pangallo, B. A., Stroud, C. E., Cai, N., & Findling, R. L. (2015). A randomized, placebo-controlled study of duloxetine for the treatment of children and adolescents with generalized anxiety disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 54(4), 283. https://doi.org/10.1016/j.jaac.2015.01.008

    Article  PubMed  Google Scholar 

  • Sylvester, C. M., Corbetta, M., Raichle, M. E., Rodebaugh, T. L., Schlaggar, B. L., Sheline, Y. I., Zorumski, C. F., & Lenze, E. J. (2012). Functional network dysfunction in anxiety and anxiety disorders. Trends in Neurosciences, 35(9), 527–535. https://doi.org/10.1016/j.tins.2012.04.012

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • The Pediatric Anxiety Rating Scale (PARS): Development and psychometric properties. (2002). Journal of the American Academy of Child and Adolescent Psychiatry, 41(9), 1061–1069. http://www.ncbi.nlm.nih.gov/pubmed/12218427

    Article  Google Scholar 

  • Tiwari, S., Kendall, P. C., Hoff, A. L., Harrison, J. P., Fizur, P. (2013) Characteristics of exposure sessions as predictors of treatment response in anxious youth. J Clin Child Adolesc Psychol, 42(1), 34–43.

    Google Scholar 

  • Varigonda, A. L., Jakubovski, E., & Bloch, M. H. (2016). Systematic review and meta-analysis: Early treatment responses of selective serotonin reuptake inhibitors and clomipramine in pediatric obsessive-compulsive disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 55(10), 851–859.e2.

    Article  Google Scholar 

  • Wagner, K. D., Berard, R., Stein, M. B., Wetherhold, E., Carpenter, D. J., Perera, P., Gee, M., Davy, K., & Machin, A. (2004). A multicenter, randomized, double-blind, placebo-controlled trial of paroxetine in children and adolescents with social anxiety disorder. Archives of General Psychiatry, 61(11), 1153–1162. https://doi.org/10.1001/archpsyc.61.11.1153

    Article  CAS  PubMed  Google Scholar 

  • Walkup, J. T., Albano, A. M., Piacentini, J., Birmaher, B., Compton, S. N., Sherrill, J. T., Ginsburg, G. S., Rynn, M. A., McCracken, J., Waslick, B., Iyengar, S., March, J. S., & Kendall, P. C. (2008). Cognitive behavioral therapy, sertraline, or a combination in childhood anxiety. The New England Journal of Medicine, 359(26), 2753–2766. https://doi.org/10.1056/NEJMoa0804633

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Walkup, J. T., Friedland, S. J., Peris, T. S., & Strawn, J. R. (2021). Dysregulation, catastrophic reactions, and the anxiety disorders. Child and Adolescent Psychiatric Clinics of North America, 30(2), 431–444.

    Article  PubMed  Google Scholar 

  • Warren, S. L., Huston, L., Egeland, B., & Sroufe, L. A. (1997). Child and adolescent anxiety disorders and early attachment. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 637. https://doi.org/10.1097/00004583-199705000-00014

    Article  CAS  PubMed  Google Scholar 

  • Waters, A. M., & Craske, M. G. (2016). Towards a cognitive-learning formulation of youth anxiety: A narrative review of theory and evidence and implications for treatment. Clinical Psychology Review, 50, 50–66.

    Article  PubMed  Google Scholar 

  • Wu, M. S., Caporino, N. E., Peris, T. S., Pérez, J., Thamrin, H., Albano, A. M., Kendall, P. C., Walkup, J. T., Birmaher, B., Compton, S. N., & Piacentini, J. (2019). The impact of treatment expectations on exposure process and treatment outcome in childhood anxiety disorders. Journal of Abnormal Child Psychology, 48(1), 79–89.

    Google Scholar 

  • Yook, K., Kim, K. H., Suh, S. Y., & Lee, K. S. (2010). Intolerance of uncertainty, worry, and rumination in major depressive disorder and generalized anxiety disorder. Journal of Anxiety Disorders, 24(6), 623–628.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Pritzker Department of Psychiatry and Behavioral Health, Ann and Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA

    John T. Walkup

  2. School of Psychological Sciences, University of Haifa, Haifa, Israel

    Tomer Shechner

  3. Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati, College of Medicine, Cincinnati, OH, USA

    Jeffrey R. Strawn

Authors
  1. John T. Walkup
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  2. Tomer Shechner
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  3. Jeffrey R. Strawn
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Corresponding author

Correspondence to John T. Walkup .

Editor information

Editors and Affiliations

  1. Department of Psychiatry, University of Louisville, Louisville, KY, USA

    Allan Tasman

  2. Department of Psychiatry, University of Michigan Rogel Cancer Cent, Ann Arbor, MI, USA

    Michelle B. Riba

  3. Mayo Clinic College of Medicine, Oakland, CA, USA

    Renato D. Alarcón

  4. Columbia University Medical Center, New York, USA

    César A. Alfonso

  5. Kyushu University, Fukuoka, Japan

    Shigenobu Kanba

  6. Department of Psychiatry, University of Nairobi, Nairobi, Kenya

    David M. Ndetei

  7. Malaysian Research Inst on Ageing, Universiti Putra Malaysia, Selangor, Malaysia

    Chee H. Ng

  8. Department of Psychiatry, University of Munich, München, Bayern, Germany

    Thomas G. Schulze

  9. Serbian Academy of Sciences and Arts, Belgrade, Serbia

    Dusica Lecic-Tosevski

Section Editor information

  1. Department of Psychiatry, University of Melbourne, Melbourne, Australia

    Chee H. Ng

  2. Department of Medical Sciences, Serbian Academy of Sciences and Arts, Belgrade, Serbia

    Dusica Lecic-Tosevski

  3. Department of Psychiatry, Columbia University Medical Center, New York, NY, USA

    César A. Alfonso

  4. Department of Psychiatry, Faculty of Medicine, National University of Malaysia, Cheras, Kuala Lumpur, Malaysia

    César A. Alfonso

  5. Department of Psychiatry, Universitas Indonesia, Jakarta, Indonesia

    César A. Alfonso

  6. Department of Psychiatry, Prince of Songkla University, Songhkla, Thailand

    César A. Alfonso

  7. Department of Neuroscience, University of Texas Rio Grande Valley School of Medicine, HARLINGEN, FL, USA

    Ihsan M. Salloum

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Walkup, J.T., Shechner, T., Strawn, J.R. (2023). Anxiety Disorder in Youth: Separation Anxiety, Social Anxiety, and Generalized Anxiety Disorders. In: Tasman, A., et al. Tasman’s Psychiatry. Springer, Cham. https://doi.org/10.1007/978-3-030-42825-9_22-1

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  • DOI: https://doi.org/10.1007/978-3-030-42825-9_22-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-42825-9

  • Online ISBN: 978-3-030-42825-9

  • eBook Packages: Springer Reference MedicineReference Module Medicine

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