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Unrelated Donor Allogeneic Transplant

  • Reference work entry
  • First Online:
Contemporary Bone Marrow Transplantation

Part of the book series: Organ and Tissue Transplantation ((OTT))

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Abstract

The major thrust in the field of allogeneic hematopoietic stem cell transplantation was due to the evolution of the unrelated donor transplant strategy. A significant majority of patients requiring HCT have low likelihood of having a matched related donor suitable for HCT. For these patients, the chance of finding the right match among the millions of donors in the registries has remarkably improved over the last several decades. This was due to advances in HLA typing technology, better matching algorithms, and a widening network of donor registries co-operating with each other. With experience accrued over many years from transplant centers around the world, the management of clinical issues associated with unrelated donor transplant has also evolved. This chapter provides an overview of the current status of unrelated donor transplant with insights in to the role of HLA biology, donor selection criteria, management challenges, and outcomes with this strategy.

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Authors and Affiliations

  1. Division of Hematology Oncology, Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee, WI, USA

    Saurabh Chhabra & Parameswaran Hari

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  1. Saurabh Chhabra
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  2. Parameswaran Hari
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Correspondence to Parameswaran Hari .

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Editors and Affiliations

  1. Clinical Hematology Oncology and Hematopoietic Cell Transplantation, Tata Medical Center, Kolkata, India

    Mammen Chandy

  2. Clinical Hematology Oncology and Hematopoietic Cell Transplantation, Tata Medical Center, Kolkata, India

    Vivek S. Radhakrishnan

  3. Department of Pediatric Hematology-Oncology, Tata Medical Center, Kolkata, India

    Reghu K. Sukumaran

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  1. Tata Medical Center, Kolkata, India

    Vivek Radhakrishnan

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Chhabra, S., Hari, P. (2021). Unrelated Donor Allogeneic Transplant. In: Chandy, M., Radhakrishnan, V.S., Sukumaran, R.K. (eds) Contemporary Bone Marrow Transplantation. Organ and Tissue Transplantation. Springer, Cham. https://doi.org/10.1007/978-3-030-36358-1_39

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  • DOI: https://doi.org/10.1007/978-3-030-36358-1_39

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