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Phytochemistry and Pharmacology of Mesua ferrea L.

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Bioactive Compounds in Underutilized Fruits and Nuts

Part of the book series: Reference Series in Phytochemistry ((RSP))

Abstract

Mesua ferrea L. (family, Clusiaceae), popularly called cobra saffron, is a rare plant traditionally used for the treatment of various ailments and is cultivated as an ornamental plant due to its graceful morphology and beautiful, fragrant large white flowers. Mesua ferrea showed wide range of various phytochemical constituents, which are responsible for different medicinal properties. Specifically it contains alkaloids, glycosides, reducing sugar, tannins, phenolics, coumarins, sterols, xanthones, volatile oil, triterpenoids, resins, and saponins. The plant also consists of various active compounds like α-copaene and germacrene D, β-amyrin, and β-sitosterol and some new compounds named as mesuanic acid; mesuferrols A and B; mesuaxanthones A and B; mesuaferrins A, B, and C; mesuaferrones A and B; mesuarin; and mesuol. The plant has shown various pharmacological activities including anti-inflammatory, anti-hemorrhoid, antiulcer, CNS depressant, α-amylase inhibitory, antioxidant, anticancer, diuretic, hepatoprotective, antivenom, antidiabetic, antibacterial, and immunomodulatory effects.

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References

  1. Chahar MK, Sanjaya Kumar DS, Geetha L, Lokesh T, Manohara KP (2013) Mesua ferrea L. a review of the medical evidence for its phytochemistry and pharmacological actions. Afr J Pharm Pharmacol 7(6):211–219

    Article  Google Scholar 

  2. Sharma A, Sharma S, Rohit N, Parashar B (2017) Mesua ferrea Linn: a review of the Indian medical herb. Sys Rev Pharm 8(1):19–23

    Article  CAS  Google Scholar 

  3. Sayeed MA, Ali MA, Sohel FI, Khan AM, Yeasmin MS (2004) Physico-chemical characteristics of Mesua ferrea seed oil and nutritional composition of its seed and leaves. Bull Chem Soc Ethiop 18(2):157–166

    CAS  Google Scholar 

  4. Choudhury S, Ahmed R, Barthel A, Leclercq PA (1998) Volatile oils of Mesua ferrea (L.) from Assam, India. J Essen Oil Res 10(5):497–501

    Article  CAS  Google Scholar 

  5. Lim TK (2012) Edible medicinal and non-medicinal plants. Springer, New York

    Book  Google Scholar 

  6. Sethi N, Nath D, Singh RK (1989) Teratological evaluation of some commonly used indigenous antifertility plants in rats. Int J Crude Drug Res 27(2):118–120

    Article  Google Scholar 

  7. Sharkar P, Rahman MM, Haque Masum GZ, Nayeem MA, Hossen MM, Azad AK (2013) Ethnomedicinal importance of the plants in villages in Kushtia Sadar and Mirpur Upazila, Bangladesh. J Herbs Spices Med Plants 19:401–417

    Google Scholar 

  8. Orwa C, Mutua A, Kindt R, Jamnadass R, Anthony S (2009) Agroforestree database: a tree reference and selection guide version 4.0. http://www.worldagroforestry.org/treedb2/speciesprofile.php?Spid=1770

  9. Wetwitayaklung P, Phaechamud T, Limmatvapirat C, Keokitichai S (2008) The study of antioxidant activities of edible flower extracts. International Society for Horticultural Science (ISHS), Leuven

    Book  Google Scholar 

  10. Joseph C, Ilanchezhian R, Biswajyoti P, Harish C (2010) Pharmacognostical study of nagakeshara (Mesua ferrea. Linn) ‑ an ingredient in Vyaghrihareetaki Avaleha. Int J Res Ayurveda Pharm 1:264–272

    Google Scholar 

  11. Keawsa-ard S, Kongtaweelert S (2012) Antioxidant, antibacterial, anticancer activities and chemical constituents of the essential oil from Mesua ferrea leaves. Chiang Mai J Sci 39:455–463

    CAS  Google Scholar 

  12. Manandhar NP (1990) Medicobotany of Borkha District, Nepal ‑ an Elucidation of medicinal plants. Int J Crude Drug Res 28:17–25

    Article  Google Scholar 

  13. Tiwari PK, Irchhaiya R, Jain SK (2012) Evaluation of anticonvulsant activity of Mesua ferrea Linn. Ethanolic flower extract. Int J Pharm Life Sci 3(3):1507–1509

    Google Scholar 

  14. Kirtikar KR, Basu BD (1935) Indian medicinal plants, vol. I. Published by Basu LM, 49 Leader Road, Allahabad, India, pp. 274

    Google Scholar 

  15. Thakur RS, Puri HS, Husain A (1989) Major medicinal plants of India. Central Institute of Medicinal and Aromatic plants (CIMAP), Lucknow

    Google Scholar 

  16. The Wealth of India (2003) A dictionary to Indian raw materials and industrial products. First supplement series (Raw materials). Volume 4: (J-Q). New Delhi India, Published by National Institute of Science Communication and Information Resources (NISCAIR), CSIR

    Google Scholar 

  17. Gopalakrishnan C, Shankarnarayanan D, Nazimudeen SK, Viswanathan S, Kameswaran L (1980) Anti-inflammatory and CNS depressant activities of xanthones from Calophyllum inophyllum and Mesua ferrea. Ind J Pharmacol 12:181–191

    CAS  Google Scholar 

  18. Tambekar DH, Dahikar SB (2010) Exploring antibacterial potential of some Ayurvedic preparations to control bacterial enteric infections. J Chem Pharm Res 2:494–501

    Google Scholar 

  19. Santamaría FJ (1978) Diccionario de Mejicanismos. 3rd ed. Editorial Porrua, SA. Mejico, DF, Mexico

    Google Scholar 

  20. Asif M, Seyedeh FJ, Zafar I, Vageesh R, Chern EO, Aman SAM, Amin MSAM (2017a) Ethnobotanical and phytopharmacological attributes of Mesua ferrea: a mini review. J Appl Pharmac Sci 7(4):242–251

    CAS  Google Scholar 

  21. Palani V, Senthilkumaran RK, Govindasamy S (1999) Biochemical evaluation of antitumor effect of muthu marunthu (a herbal formulation) on experimental fibro sarcoma in rats. J Ethnopharmacol 65:257–265

    Article  CAS  PubMed  Google Scholar 

  22. Rai LK, Pankaj P, Sharma E (2000) Conservation threats to some important medicinal plants of the Sikkim Himalaya. Biol Conserv 93:27–33

    Article  Google Scholar 

  23. Khare CP (2004) Indian herbal remedies: rational western therapy, ayurvedic and other traditional usage, botany. Springer, Berlin

    Book  Google Scholar 

  24. Sahu Alakh N, Hemalatha S, Sairam K (2013) Quality control studies of Mesua ferrea Linn. Flowers. Int J Herb Med 1(2):124–130

    Google Scholar 

  25. Chow YL, Quon HH (1968) Chemical constituents of the heartwood of Mesua ferrea. Phytochemistry 7(10):1871–1874

    Article  CAS  Google Scholar 

  26. Bala KR, Seshadri TR (1971) Isolation and synthesis of some coumarin components of Mesua ferrea seed oil. Phytochemistry 10(5):1131–1134

    Article  CAS  Google Scholar 

  27. Raju MS, Srimannarayana G, Rao NVS, Bala KR, Seshadri TR (1976) Structure of mesuaferrone-B, a new biflavanone from the stamens of Mesua ferrea Linn. Tetrahedron Lett 17(49):4509–4512

    Article  Google Scholar 

  28. Chukaew A, Saithong S, Chusri S, Limsuwan S, Watanapokasin R, Voravuthikunchai SP, Chakthong S (2019) Cytotoxic xanthones from the roots of Mesua ferrea L. Phytochemistry 157:64–70

    Article  CAS  PubMed  Google Scholar 

  29. Govindachari TR, Pai BR, Subramaniam PS, Ramdas Rao U, Muthukumaraswamy N (1967) Constituents of Mesua ferrea L.-II: ferruol A, a new 4alkylcoumarin. Tetrahedron 23(10):4161–4165

    Article  CAS  Google Scholar 

  30. Iinuma M, Tosa H, Tanaka Y, Riswan S (1996) Two new dimeric xanthones in Mesua ferrea. Heterocycles 43(9):1999–2004

    Article  CAS  Google Scholar 

  31. Walia S, Mukerjee SK (1984) Ferrxanthone, a 1,3,5,6-tetraoxygenated xanthone from Mesua ferrea. Phytochemistry 23(8):1816–1817

    Article  CAS  Google Scholar 

  32. Raju MS, Srimannarayana G, Rao NVS (1978) Structure of mesuaferrone-A, a new biflavanone from the stamens of Mesua ferrea Linn. Ind J Chem Sec B 16B(2):167–168

    CAS  Google Scholar 

  33. Bhattacharyya P, Chakrabartty P, Chowdhuty BK (1988) Mesuarin: a new 4phenyl-coumarin from Mesua ferrea L. Chem Indust 7:239–240

    Google Scholar 

  34. Chakraborty DP, Chatterji D (1969) Structure of mesuagin, a new 4phenylcoumarin. J Org Chem 34(12):3784–3786

    Article  CAS  PubMed  Google Scholar 

  35. Raju MS, Rao NVS (1969) Isolation of mammeisin from the seeds of Mesua ferrea. Ind J Chem 7(12):1278–1279

    CAS  Google Scholar 

  36. Surveswarna S, Cai Y-Z, Corke H, Sun M (2007) Systematic evaluation of natural phenolic antioxidants from 133 Indian medicinal plants. Food Chem 102:938–953

    Article  CAS  Google Scholar 

  37. Makchuchit S, Itharat A, Tewtrakul S (2010) Antioxidant and nitric oxide inhibition activities of Thai medicinal plants. J Med Asso Thai 93(7):S227–S235

    Google Scholar 

  38. Yadav AS, Bhatnagar D (2010) Inhibition of iron induced lipid peroxidation and antioxidant activity of Indian species and Acacia in vitro. Hum Nutr 65:18–24

    Google Scholar 

  39. Hassan MT, Ali MS, Alimuzzaman M, Raihan SZ (2006) Analgesic activity of Mesua ferrea Linn. Dhaka Univ J Pharm Sci 5:73–75

    Article  Google Scholar 

  40. Prasad DN, Basu SP, Srivastava AK (1999) Antispasmodic activity of the crude and purified oil of Mesua ferrea seed. Anc Sci Life 19:74–75

    CAS  PubMed  PubMed Central  Google Scholar 

  41. Uawonggul N, Chaveerach A, Thammasirirak S, Arkaravichien T, Chuachan C, Daduang S (2006) Screening of plants acting against Heterometrus laoticus scorpion venom activity on fibroblast cell lysis. J Ethnopharmacol 103:201–207

    Article  PubMed  Google Scholar 

  42. Chahar MK, Ds SK, Lokesh T, Manohara KP (2012) In vivo antioxidant and immunomodulatory activity of mesuol isolated from Mesua ferrea L. seed oil. Int Immunophrmacol 13:386–391

    Article  CAS  Google Scholar 

  43. Mahavorasirikul W, Viyanant V, Chaijaroenkul W, Itharat A, Na-Bangchang K (2010) Cytotoxic activity of Thai medicinal plants against human cholangiocarcinoma, laryngeal and hepatocarcinoma cells in vitro. BMC Compl Altern Med 10:55

    Article  Google Scholar 

  44. Tiwari PK, Irchhiya R, Jain SK (2012) Evaluation of anticonvulsant activity of Mesua ferrea Linn. Ethanolic flower extract. Int J Pharm Lif Sci 23:1507–1509

    Google Scholar 

  45. Ali MA, Sayeed MA, Bhuiyan MSA, Sohel FI, Yeasmin MS (2004) Antibacterial screening of Cassia fistula and Mesua ferrea. J Med Sci 4:24–29

    Article  Google Scholar 

  46. Parekh J, Chanda S (2007) In vitro screening of antibacterial activity of aqueous and alcoholic extracts of various Indian plant species against selected pathogens from Enterobacteriaceae. Afr J Microbiol Res 1:92–99

    Google Scholar 

  47. Verotta L, Lovaglio E, Vidari G, Finzi PV, Neri MG, Raimondi A, Parapini S, Taramelli D, Riva A, Bombardelli E (2004) 4-alkyl and 4-phenly coumairns from Mesua ferrea as promising multi drug resistant bacteria. Phtochemistry 65:2867–2869

    Google Scholar 

  48. Adewale AI, Mirghani MES, Muyibi SA, Daoud JI, Amimbola MM (2012) Anti-bacerial and cytotoxicity properties of the leaves extract of Nahar (Mesua ferrea). Plant Adv Nat Appl Sci 6:583–587

    Google Scholar 

  49. Verotta L, Lovaglio E, Vidari G, Finzi PV, Neri MG, Raimondi A, Parapini S, Taramelli D, Riva A, Bombardelli E (2004) 4-Alkyl- and 4-phenylcoumarins from Mesua ferrea as promising multidrug resistant antibacterials. Phytochemistry 65(21):8672879

    Article  CAS  Google Scholar 

  50. Alam MS, Jain N, Kamil M, Ilyas M (1987) Mesuein: a novel flavanone glycoside from Mesua ferrea. Chem Indust 16:565–566

    Google Scholar 

  51. Teh SS, Ee GCL, Rahmani M, Taufiq-Yap YH, Go R, Mah SH (2011) Pyranoxanthones from Mesua ferrea. Molecules 16(7):5647–5654

    Article  CAS  PubMed Central  Google Scholar 

  52. Teh SS, Ee GCL, Mah SH, Lim YM, Ahmad Z (2013b) Cytotoxicity and structure-activity relationships of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards nine human cancer cell lines. Molecules 18(2):1985–1994

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Dennis TJ, Kumar KA, Srimannarayana G (1988) A new cyclo hexadione from Mesua ferrea. Phytochemistry 27(7):2325–2327

    Article  CAS  Google Scholar 

  54. Gomathi C (2015) Bioactive 4-phenylcoumarins from Mesua elegans and Mesua kunstleri. Thesis submitted to faculty of science, University of Malaya Kuala Lumpur

    Google Scholar 

  55. Paranjpe P, Patki P, Joshi N (2000) Efficacy of an indigenous formulation in patients with bleeding piles: a preliminary clinical study. Fitoterapia 71:41–45

    Article  CAS  PubMed  Google Scholar 

  56. Aggrawal K, Satija N, Dasgupta G, Dasgupta P, Nain P, Sahu AR (2014) Efficacy of a standardized herbal preparation (Roidosanal®) in the treatment of hemorrhoids: a randomized, controlled, open-label multicentre study. J Ayurveda Integr Med 5:117–124

    Article  PubMed  PubMed Central  Google Scholar 

  57. Choudhary GP (2012) Wound healing activity of the ethanolic extract of Mesua ferrea Linn. Int J Adv Pharm Biol Chem 1:36971

    Google Scholar 

  58. Teh SS, Ee GCL, Mah SH, Ahmad Z (2016) Structure–activity relationship study of secondary metabolites from Mesua beccariana, Mesua ferrea and Mesua congestiflora for anti-cholinesterase activity. Med Chem Res 25(5):1–5

    Article  CAS  Google Scholar 

  59. Chakrabarti R, Singh B, Prakrith VN, Vanchhawng L, Thirumurugan K (2014) Screening of nine herbal plants for in vitro α-amylase inhibition. Asian J Pharm Clin Res 7:84–89

    Google Scholar 

  60. Rajesh KP, Manjunatha H, Krishna V, Kumara Swamy BE (2013) Potential in vitro antioxidant and protective effects of Mesua ferrea Linn. Bark extracts on induced oxidative damage. Ind Crop Prod 47:18698

    Article  CAS  Google Scholar 

  61. Ranganathaiah P, Hanumanthappa M, Venkatarangaiah K (2016) Evaluation of in vitro anti-inflammatory activity of stem bark extracts of Mesua ferrea Linn. Int J Pharm Pharm Sci 8:173–177

    CAS  Google Scholar 

  62. Keawsa-ard S, Liawruangrath B, Kongtaweelert S (2015) Bioactive compounds from Mesua ferrea stems. Chiang Mai J Sci 42:185–195

    CAS  Google Scholar 

  63. Asif M, Al-Mansoub MA, Khan MDSS, Yehya AHS, Ezzat MO, Oon CE, Atif M, Abdul Majid AS, Abdul Majid AMS (2017b) Molecular mechanisms responsible for programmed cell death inducing attributes of terpenes from Mesua ferrea stem bark towards human colorectal carcinoma HCT 116 cells. J Appl Biomed 15:71–80

    Article  Google Scholar 

  64. Sahu Alakh N, Hemalatha S, Sairam K (2013a) HPTLC fingerprinting and in vitro antioxidant studies of Argyreia speciosa sweet leaves and Mesua ferrea Linn. Flowers. Int J Res Ayurveda Pharm 4:499–502

    Article  CAS  Google Scholar 

  65. Barbade KD, Datar AG (2015) Extraction, bioactivities, phytochemical investigation and in-vivo toxicity studies of Mesua Ferrea L. stamens. Int J Pharm Pharm Sci 7:93–97

    Google Scholar 

  66. Mazumder R, Dastidar SG, Basu SP, Mazumder A, Singh SK (2004) Antibacterial potentiality of Mesua ferrea Linn. Flowers. Phytother Res 18:426–428

    Google Scholar 

  67. Tiwari P, Patel RK (2011) Evaluation of diuretic potential of draksharishta prepared by traditional and modern methods in experimental rats. Pharmacologyonline 3:566–572

    Google Scholar 

  68. Garg S, Sharma K, Ranjan R, Attri P, Mishra P (2009) In vivo antioxidant activity and hepatoprotective effects of methanolic extract of Mesua ferrea Linn. Int J PharmTech Res 1:1692–1696

    Google Scholar 

  69. Tiwari P, Patel RK (2012) Cardioprotective activity of ashwagandharishta on isoproterenol induced myocardial infarction. Pharmacologyonline 1:17–24

    Google Scholar 

  70. Nordin A, Ahmad FBH, Taufiq-Yap YH, Ali AM (2004) Volatile components of methanol extract from the flower of Malaysian Mesua ferrea Linn. Orient J Chem 20:69–72

    CAS  Google Scholar 

  71. Mahavorasirikul W, Viyanant V, Chaijaroenkul W, Itharat A, Na-Bangchang K (2010) Cytotoxic activity of Thai medicinal plants against human cholangiocarcinoma, laryngeal and hepatocarcinoma cells in vitro. BMC Complement Altern Med 28:10–55

    Google Scholar 

  72. Noysang C, Mahringer A, Zeino M, Saeed M, Luanratana O, Fricker G, Bauer R, Efferth T (2014) Cytotoxicity and inhibition of P-glycoprotein by selected medicinal plants from Thailand. J Ethnopharmacol 155:633–641

    Article  PubMed  Google Scholar 

  73. Rana AYKMM, Khanam JA, Asad-Ud-Daula M (2004) Antineoplastic screening of some medicinal plants against ehrlich ascites carcinoma in mice. Int J Med Sci 4:142–145

    Google Scholar 

  74. Udayabhanu J, Kaminidevi S, Thangavelu T (2014) A study on acute toxicity of methanolic extract of Mesua ferrea L. in Swiss albino mice. Asian J Pharm Clin Res 7:66–68

    Google Scholar 

  75. Jalalpure SS, Mandavkar YD, Khalure PR, Shinde GS, Shelar PA, Shah AS (2011) Antiarthritic activity of various extracts of Mesua ferrea Linn. Seed. J Ethnopharmacol 138:700–704

    Article  PubMed  Google Scholar 

  76. Prasad DN, Rao BG, Rao ES, Rao TM, Praneeth DVS (2012) Quantification of phytochemical constituents and in-vitro antioxidant activity of Mesua ferrea leaves. Asian Pac J Trop Biomed 2:S539–S542

    Article  Google Scholar 

  77. Mazumder R, Dastidar SG, Basu SP, Mazumder A, Kumar S (2003) Emergence of Mesua ferrea Linn. Leaf extract as a potent bactericide. Ancient Sci Life 22:160–165

    Google Scholar 

  78. Narender Prasad D, Ganga Rao B, Prayaga Murthy P, Sambasiva Rao E, Mallikarjuna Rao T, Praneeth DVS (2011) Evaluation of phytochemical constituents and in-vitro antibacterial activity of Mesua ferrea leaves. Int J Pharm Technol 3:3624–3630

    Google Scholar 

  79. Balekari U, Veeresham C (2015) Insulinotropic activity of methanolic extract of Mesua ferrea Linn. J Basic Appl Sci 11:410–417

    Article  CAS  Google Scholar 

  80. Teh S, Ee G, Mah S, Yong Y, Lim Y, Rahmani M, Ahmad Z (2013a) In vitro cytotoxic, antioxidant, and antimicrobial activities of Mesua beccariana (Baill.) Kosterm., Mesua ferrea Linn., and Mesua congestiflora extracts. Biomed Res Int. https://doi.org/10.1155/2013/517072

  81. Das G, Kalita RD, Gogoi P, Buragohain AK, Karak N (2014) Antibacterial activities of copper nanoparticle-decorated organically modified montmorillonite/epoxy nanocomposites. Appl Clay Sci 90:18–26

    Article  CAS  Google Scholar 

  82. Phukan MM, Chutia RS, Kumar R, Kalita D, Konwar BK, Kataki R (2013) Assessment of antimicrobial activity of bio-oil from Pongamia Glabra, Mesua ferrea and Parachlorella spp deoiled cake. Int J Pharm Bio Sci 4:P910–P918

    Google Scholar 

  83. Adewale AI, Mirghani MES, Muyibi SA, Daoud JI, Abimbola MM (2011) Disinfection studies of Nahar (Mesua ferrea) seed kernel oil using pour plate method. Afr J Biotechnol 10:18749–18754

    Google Scholar 

  84. Chahar MK, Sanjaya Kumar DS, Lokesh T, Manohara KP (2012) In-vivo antioxidant and immunomodulatory activity of mesuol isolated from Mesua ferrea L. seed oil. Int Immunopharmacol 13(4):386–391

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

SERB, National Post Doctoral Fellowship to PRK from DST, Government of India, and Dr. D. S. Kothari Post Doctoral Fellowship to SMP from UGC New Delhi India with Department of Biotechnology, Shivaji University Kolhapur and Amity University, Panvel, Mumbai, are gratefully acknowledged.

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Kshirsagar, P.R., Patil, S.M. (2020). Phytochemistry and Pharmacology of Mesua ferrea L.. In: Murthy, H., Bapat, V. (eds) Bioactive Compounds in Underutilized Fruits and Nuts. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-030-30182-8_16

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