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Antimicrobial Prophylaxis in the Age of Emerging Transplant Infections

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Emerging Transplant Infections

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Abstract

Solid organ transplantation and hematopoietic cell transplantation are life-saving procedures, yet carry significant infection risk due to the significant and prolonged immunosuppression they entail. Infection prevention strategies using antibiotic prophylaxis can mitigate problems that arise through immunosuppression, especially if clinicians have a keen awareness for local epidemiology and patient-specific microbiological factors. Antifungal prophylaxis, especially in stem cell transplantation, is now standard of care for most institutions. Although there is variability in the incidence and seasonality of viral disease in transplanted populations, a tailored approach to antiviral prophylaxis can also substantially attenuate the risk of post-transplant disease.

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References

  1. Abbo LM, Grossi PA, Practice AICo. Surgical site infections: guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transpl. 2019;33:e13589.

    Article  Google Scholar 

  2. Reid GE, Grim SA, Sankary H, Benedetti E, Oberholzer J, Clark NM. Early intra-abdominal infections associated with orthotopic liver transplantation. Transplantation. 2009;87(11):1706–11.

    Article  PubMed  Google Scholar 

  3. Allegranzi B, Zayed B, Bischoff P, et al. New WHO recommendations on intraoperative and postoperative measures for surgical site infection prevention: an evidence-based global perspective. Lancet Infect Dis. 2016;16(12):e288–303.

    Article  PubMed  Google Scholar 

  4. de Jonge SW, Gans SL, Atema JJ, Solomkin JS, Dellinger PE, Boermeester MA. Timing of preoperative antibiotic prophylaxis in 54,552 patients and the risk of surgical site infection: a systematic review and meta-analysis. Medicine (Baltimore). 2017;96(29):e6903.

    Article  Google Scholar 

  5. Berry PS, Rosenberger LH, Guidry CA, Agarwal A, Pelletier S, Sawyer RG. Intraoperative versus extended antibiotic prophylaxis in liver transplant surgery: a randomized, controlled pilot trial. Liver Transpl. 2019;25:1043–53.

    Article  PubMed  Google Scholar 

  6. Tacconelli E, Mazzaferri F, de Smet AM, et al. ESCMID-EUCIC clinical guidelines on decolonization of multidrug-resistant Gram-negative bacteria carriers. Clin Microbiol Infect. 2019;25:807–17.

    Article  CAS  PubMed  Google Scholar 

  7. Wolfe CR, Ison MG, Practice ASTIDCo. Donor-derived infections: guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transpl. 2019;33:e13547.

    Article  Google Scholar 

  8. Urbancic KF, Ierino F, Phillips E, Mount PF, Mahony A, Trubiano JA. Taking the challenge: a protocolized approach to optimize Pneumocystis pneumonia prophylaxis in renal transplant recipients. Am J Transplant. 2018;18(2):462–6.

    Article  CAS  PubMed  Google Scholar 

  9. Navin TR, Beard CB, Huang L, et al. Effect of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of P carinii pneumonia in patients with HIV-1: a prospective study. Lancet. 2001;358(9281):545–9.

    Article  CAS  PubMed  Google Scholar 

  10. Restrepo A, Clark NM, Infectious Diseases Community of Practice of the American Society of T. Nocardia infections in solid organ transplantation: guidelines from the Infectious Diseases Community of Practice of the American Society of Transplantation. Clin Transpl. 2019;33(9):e13509. https://doi.org/10.1111/ctr.13509. Epub 2019 Mar 19.

  11. Goldman JD, Julian K. Urinary tract infections in solid organ transplant recipients: guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transpl. 2019;33:e13507.

    Article  Google Scholar 

  12. Lee JH, Muthukumar T, Kim J, et al. Antibiotic prophylaxis for ureteral stent removal after kidney transplantation. Clin Transpl. 2019;33(3):e13491.

    Article  CAS  Google Scholar 

  13. Mikulska M, Averbuch D, Tissot F, et al. Fluoroquinolone prophylaxis in haematological cancer patients with neutropenia: ECIL critical appraisal of previous guidelines. J Infect. 2018;76(1):20–37.

    Article  PubMed  Google Scholar 

  14. Kern WV, Weber S, Dettenkofer M, et al. Impact of fluoroquinolone prophylaxis during neutropenia on bloodstream infection: data from a surveillance program in 8755 patients receiving high-dose chemotherapy for haematologic malignancies between 2009 and 2014. J Infect. 2018;77(1):68–74.

    Article  PubMed  Google Scholar 

  15. Satlin MJ, Chavda KD, Baker TM, et al. Colonization with levofloxacin-resistant extended-spectrum beta-lactamase-producing Enterobacteriaceae and risk of bacteremia in hematopoietic stem cell transplant recipients. Clin Infect Dis. 2018;67(11):1720–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  16. Ullmann AJ, Schmidt-Hieber M, Bertz H, et al. Infectious diseases in allogeneic haematopoietic stem cell transplantation: prevention and prophylaxis strategy guidelines 2016. Ann Hematol. 2016;95(9):1435–55.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Doan VP, Yeh JC, Gulbis AM, Aitken SL, Ariza-Heredia E, Ahmed S. Levofloxacin versus cefpodoxime for antibacterial prophylaxis in allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2019;25:1637–41.

    Article  CAS  PubMed  Google Scholar 

  18. Pappas PG, Alexander BD, Andes DR, et al. Invasive fungal infections among organ transplant recipients: results of the Transplant-Associated Infection Surveillance Network (TRANSNET). Clin Infect Dis. 2010;50(8):1101–11.

    Article  PubMed  Google Scholar 

  19. Aslam S, Rotstein C, Practice ASTIDCo. Candida infections in solid organ transplantation: guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transpl. 2019;33(9):e13623.

    Article  Google Scholar 

  20. Kullberg BJ, Viscoli C, Pappas PG, et al. Isavuconazole versus caspofungin in the treatment of candidemia and other invasive Candida infections: the ACTIVE trial. Clin Infect Dis. 2019;68(12):1981–9.

    Article  CAS  PubMed  Google Scholar 

  21. Samanta P, Clancy CJ, Marini RV, et al. Isavuconazole is as effective as and better tolerated than voriconazole for antifungal prophylaxis in lung transplant recipients. Clin Infect Dis. 2020;ciaa652. https://doi.org/10.1093/cid/ciaa652. Online ahead of print.

  22. Taplitz RA, Kennedy EB, Bow EJ, et al. Antimicrobial prophylaxis for adult patients with cancer-related immunosuppression: ASCO and IDSA clinical practice guideline update. J Clin Oncol. 2018;36(30):3043–54.

    Article  PubMed  Google Scholar 

  23. Baden LR, Swaminathan S, Angarone M, et al. Prevention and treatment of cancer-related infections, version 2.2016, NCCN clinical practice guidelines in oncology. J Natl Compr Cancer Netw. 2016;14(7):882–913.

    Article  CAS  Google Scholar 

  24. Schwartz IS, Patterson TF. The emerging threat of antifungal resistance in transplant infectious diseases. Curr Infect Dis Rep. 2018;20(3):2.

    Article  PubMed  Google Scholar 

  25. Husain S, Camargo JF. Invasive aspergillosis in solid-organ transplant recipients: guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transpl. 2019;33(9):e13544.

    Article  Google Scholar 

  26. Baker AW, Maziarz EK, Arnold CJ, et al. Invasive fungal infection after lung transplantation: epidemiology in the setting of antifungal prophylaxis. Clin Infect Dis. 2020;70(1):30–9.

    Article  PubMed  Google Scholar 

  27. Fontana L, Perlin DS, Zhao Y, et al. Isavuconazole prophylaxis in patients with hematologic malignancies and hematopoietic cell transplant recipients. Clin Infect Dis. 2020;70(5):723–30.

    Article  CAS  PubMed  Google Scholar 

  28. Stern A, Su Y, Lee YJ, et al. A single-center, open-label trial of isavuconazole prophylaxis against invasive fungal infection in patients undergoing allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2020;26(6):1195–202.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Corzo-Leon DE, Satlin MJ, Soave R, et al. Epidemiology and outcomes of invasive fungal infections in allogeneic haematopoietic stem cell transplant recipients in the era of antifungal prophylaxis: a single-centre study with focus on emerging pathogens. Mycoses. 2015;58(6):325–36.

    Article  PubMed  Google Scholar 

  30. Miller R, Assi M, Practice ASTIDCo. Endemic fungal infections in solid organ transplant recipients-guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transpl. 2019;33(9):e13553.

    Article  Google Scholar 

  31. Thompson GR 3rd, Rendon A, Ribeiro Dos Santos R, et al. Isavuconazole treatment of cryptococcosis and dimorphic mycoses. Clin Infect Dis. 2016;63(3):356–62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Subramanian AK, Theodoropoulos NM, Infectious Diseases Community of Practice of the American Society of T. Mycobacterium tuberculosis infections in solid organ transplantation: guidelines from the infectious diseases community of practice of the American Society of Transplantation. Clin Transpl. 2019;33:e13513.

    Article  Google Scholar 

  33. Subramanian AK. Tuberculosis in solid organ transplant candidates and recipients: current and future challenges. Curr Opin Infect Dis. 2014;27(4):316–21.

    Article  PubMed  Google Scholar 

  34. Longworth SA, Daly JS, Practice ASTIDCo. Management of infections due to non-tuberculous mycobacteria in transplant recipients – guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transpl. 2019;33:e13588.

    Article  Google Scholar 

  35. Perez AA, Singer JP, Schwartz BS, et al. Management and clinical outcomes after lung transplantation in patients with pre-transplant Mycobacterium abscessus infection: a single center experience. Transpl Infect Dis. 2019;21:e13084.

    Article  PubMed  Google Scholar 

  36. Uyeki TM, Bernstein HH, Bradley JS, et al. Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak management of seasonal influenzaa. Clin Infect Dis. 2019;68(6):895–902.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Manuel O, Estabrook M, American Society of Transplantation Infectious Diseases Community of P. RNA respiratory viral infections in solid organ transplant recipients: guidelines from the American Society of Transplantation infectious diseases community of practice. Clin Transpl. 2019;33:e13511.

    Article  Google Scholar 

  38. Lee DH, Zuckerman RA, Practice ASTIDCo. Herpes simplex virus infections in solid organ transplantation: guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transpl. 2019;33:e13526.

    Google Scholar 

  39. Ariza-Heredia EJ, Chemaly RF, Shahani LR, Jang Y, Champlin RE, Mulanovich VE. Delay of alternative antiviral therapy and poor outcomes of acyclovir-resistant herpes simplex virus infections in recipients of allogeneic stem cell transplant – a retrospective study. Transpl Int. 2018;31(6):639–48.

    Article  CAS  PubMed  Google Scholar 

  40. Razonable RR, Humar A. Cytomegalovirus in solid organ transplant recipients-guidelines of the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transpl. 2019;33:e13512.

    Article  Google Scholar 

  41. Shmueli E, Or R, Shapira MY, et al. High rate of cytomegalovirus drug resistance among patients receiving preemptive antiviral treatment after haploidentical stem cell transplantation. J Infect Dis. 2014;209(4):557–61.

    Article  PubMed  Google Scholar 

  42. Marty FM, Ljungman P, Chemaly RF, et al. Letermovir prophylaxis for cytomegalovirus in hematopoietic-cell transplantation. N Engl J Med. 2017;377(25):2433–44.

    Article  CAS  PubMed  Google Scholar 

  43. Kotton CN. Updates on antiviral drugs for cytomegalovirus prevention and treatment. Curr Opin Organ Transplant. 2019;24(4):469–75.

    Article  CAS  PubMed  Google Scholar 

  44. Limaye AP, Green ML, Edmison BC, et al. Prospective assessment of cytomegalovirus immunity in high-risk donor-seropositive/recipient-seronegative liver transplant recipients receiving either preemptive therapy or antiviral prophylaxis. J Infect Dis. 2019;220:752–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Patel SJ, Knight RJ, Kuten SA, et al. Ciprofloxacin for BK viremia prophylaxis in kidney transplant recipients: results of a prospective, double-blind, randomized, placebo-controlled trial. Am J Transplant. 2019;19(6):1831–7.

    Article  CAS  PubMed  Google Scholar 

  46. La Hoz RM, Morris MI, Practice ASTIDCo. Intestinal parasites including Cryptosporidium, Cyclospora, Giardia, and microsporidia, Entamoeba histolytica, Strongyloides, schistosomiasis, and Echinococcus: guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transpl. 2019;33:e13618.

    Google Scholar 

  47. La Hoz RM, Morris MI, Infectious Diseases Community of Practice of the American Society of T. Tissue and blood protozoa including toxoplasmosis, Chagas disease, leishmaniasis, Babesia, Acanthamoeba, Balamuthia, and Naegleria in solid organ transplant recipients- guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transpl. 2019;33:e13546.

    Google Scholar 

  48. Asberg A, Humar A, Rollag H, et al. Oral valganciclovir is noninferior to intravenous ganciclovir for the treatment of cytomegalovirus disease in solid organ transplant recipients. Am J Transplant. 2007;7(9):2106–13.

    Article  CAS  PubMed  Google Scholar 

  49. Len O, Gavalda J, Aguado JM, et al. Valganciclovir as treatment for cytomegalovirus disease in solid organ transplant recipients. Clin Infect Dis. 2008;46(1):20–7.

    Article  CAS  PubMed  Google Scholar 

  50. Kotton CN, Kumar D, Caliendo AM, et al. The third international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation. Transplantation. 2018;102(6):900–31.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Infectious Diseases, Ochsner Health, University of Queensland School of Medicine, Ochsner Clinical School, New Orleans, LA, USA

    Jonathan Hand

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  1. Jonathan Hand
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Correspondence to Jonathan Hand .

Editor information

Editors and Affiliations

  1. Immunocompromised Host Service Division of Infectious Diseases, University of Miami Miller School of Medicine, Miami, FL, USA

    Michele I. Morris

  2. Transplant and Immunocompromised Host Infectious Diseases, Infectious Diseases Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Camille Nelson Kotton

  3. Division of Infectious Diseases, Duke University School of Medicine, Durham, NC, USA

    Cameron R. Wolfe

Section Editor information

  1. Duke University, Durham, NC, USA

    Cameron R. Wolfe

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Hand, J. (2021). Antimicrobial Prophylaxis in the Age of Emerging Transplant Infections. In: Morris, M.I., Kotton, C.N., Wolfe, C.R. (eds) Emerging Transplant Infections. Springer, Cham. https://doi.org/10.1007/978-3-030-25869-6_7

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  • DOI: https://doi.org/10.1007/978-3-030-25869-6_7

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-25868-9

  • Online ISBN: 978-3-030-25869-6

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