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Regenerative Therapies for Acquired Axonal Neuropathies

  • Living reference work entry
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Peripheral Nerve Tissue Engineering and Regeneration

Part of the book series: Reference Series in Biomedical Engineering ((TIENRE))

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Abstract

Peripheral neuropathies (PN) are the most common neurodegenerative disease globally. A variety of different insults lead to PN which include diabetes, cancer chemotherapy, and infectious diseases (such as HIV, Campylobacter jejuni, and hepatitis C). The clinical signs and symptoms depend on the extent of damage to motor, sensory, and autonomic fibers as well as the pain systems. Despite this heterogeneity of etiologies, the pathogenesis of PN is confined to one of several biological mechanisms that lead to eventual axonal degeneration. These molecular mechanisms allow identification of appropriate therapeutic targets to promote regeneration and functional recovery, but so far none of these preclinical discoveries resulted in clinical success. In addition, the poor ability of regenerating axons to reach their target represents a significant challenge to the development of effective regenerative therapies. This has stimulated research into new therapeutic delivery strategies. As a result, transdermal drug delivery and gene therapy have emerged as ideal candidates to circumvent these challenges. This chapter provides an insight into how these technologies can be harnessed to maximize the benefit of regenerative therapies for acquired axonal PN.

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Acknowledgments

This work was supported by a UCL Graduate Research Scholarship and England Golf Trust Scholarship to M.W. and Dr. Miriam and Sheldon G. Adelson Medical Research Foundation and NIH (R01 NS091260) to A.H.

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Authors and Affiliations

  1. Department of Pharmacology, UCL School of Pharmacy, University College London, London, UK

    Matthew Wilcox

  2. Peripheral Nerve Injury Research Unit, Royal National Orthopaedic Hospital, Stanmore, UK

    Matthew Wilcox

  3. UCL Centre for Nerve Engineering, University College London, London, UK

    Matthew Wilcox

  4. Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Aysel Cetinkaya-Fisgin & Ahmet Höke

Authors
  1. Matthew Wilcox
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  2. Aysel Cetinkaya-Fisgin
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  3. Ahmet Höke
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Corresponding author

Correspondence to Ahmet Höke .

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Editors and Affiliations

  1. Pharmacology, UCL School of Pharmacy, University College London Pharmacology, UCL School of Pharmacy, London, UK

    James Phillips

  2. Experimentelle u Klinische Traumatologie, Ludwig Boltzmann Institut für, Wien, Wien, Austria

    David Hercher

  3. Trauma Surgery, AUVA Unfallkrankenhaus Lorenz Böhler, Wien, Wien, Austria

    Thomas Hausner

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Wilcox, M., Cetinkaya-Fisgin, A., Höke, A. (2020). Regenerative Therapies for Acquired Axonal Neuropathies. In: Phillips, J., Hercher, D., Hausner, T. (eds) Peripheral Nerve Tissue Engineering and Regeneration. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-030-06217-0_19-1

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  • DOI: https://doi.org/10.1007/978-3-030-06217-0_19-1

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  • Print ISBN: 978-3-030-06217-0

  • Online ISBN: 978-3-030-06217-0

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