The Immune Response and Implications for Nerve Repair

Roberton, Victoria H.

doi:10.1007/978-3-030-06217-0_15-1

Victoria H. Roberton⁴

Part of the book series: Reference Series in Biomedical Engineering ((TIENRE))

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Abstract

This chapter aims to provide an overview of the host response to allografts or tissue-engineered constructs containing allogeneic cells in peripheral nerve repair, and potential approaches for promoting the survival of nerve grafts. A large body of current research aims to improve surgical approaches for nerve repair beyond that of the autograft. Potential approaches include nerve allografts, or tissue-engineered nerve constructs which could provide an unlimited source of donor tissue for nerve injury repair. This field requires an interdisciplinary approach to the design of novel therapies, and consideration of the immune response to transplants should not be overlooked. There are many benefits of including living donor cells within transplanted nerve conduits which can improve axonal guidance, vascularization, and promote the release of growth factors to increase regeneration. It is most likely that donor cells or tissues will be of allogeneic origin, with associated implications for eliciting an immune response on transplantation. The following sections provide a summary of the immune response to nerve grafts for consideration in the development of approaches to nerve repair, including some approaches currently under investigation for preventing rejection of transplants.

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Department of Pharmacology, UCL School of Pharmacy, UCL Centre for Nerve Engineering, University College London, London, UK
Victoria H. Roberton

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Victoria H. Roberton
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Correspondence to Victoria H. Roberton .

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Pharmacology, UCL School of Pharmacy, University College London Pharmacology, UCL School of Pharmacy, London, UK
James Phillips
Experimentelle u Klinische Traumatologie, Ludwig Boltzmann Institut für, Wien, Wien, Austria
David Hercher
Trauma Surgery, AUVA Unfallkrankenhaus Lorenz Böhler, Wien, Wien, Austria
Thomas Hausner

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Roberton, V.H. (2021). The Immune Response and Implications for Nerve Repair. In: Phillips, J., Hercher, D., Hausner, T. (eds) Peripheral Nerve Tissue Engineering and Regeneration. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-030-06217-0_15-1

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DOI: https://doi.org/10.1007/978-3-030-06217-0_15-1
Received: 19 April 2021
Accepted: 20 April 2021
Published: 19 June 2021
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-06217-0
Online ISBN: 978-3-030-06217-0
eBook Packages: Springer Reference EngineeringReference Module Computer Science and Engineering

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