Abstract
The use of drugs in space has been largely experimental as it has been over the years in supporting humans in various other extreme environments. However, space is different in that the progression of physiological changes has not adapted to-date and it entails being removed from the influence of gravity. It has become clear that systematic experimentation in space to develop an comprehensive understanding of pharmacokinetics and pharmacodynamics will be extremely limited. Alternate, creative approaches are needed to provide a reliable basis for therapeutic decisions in the remote environment of space. A data base in ground simulation models such as bed rest needs to be established. In addition, it may be useful to explore the value of the substantial gerontological pharmacological experience as a reliable and extensive resource.
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Vernikos, J. (2022). Medications in Microgravity: History, Facts, and Future Trends. In: Pathak, Y.V., Araújo dos Santos, M., Zea, L. (eds) Handbook of Space Pharmaceuticals. Springer, Cham. https://doi.org/10.1007/978-3-030-05526-4_20
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