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Vascularization of 3D Engineered Tissues

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Tissue-Engineered Vascular Grafts

Part of the book series: Reference Series in Biomedical Engineering ((TIENRE))

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Abstract

Cell-based tissue engineering technology has emerged as a new therapeutic option for repairing and restoring damaged tissue or organ. Vascularization (angiogenesis) is a fundamental requirement to provide oxygen/nutrients and remove the waste product for maintaining the phenotypes and functionality of implanted cells. Over the last decade, various strategies have been introduced to improve vascularization of 3D engineered tissue by developing technologies related to angiogenic factor delivery system, cell transplantation, HIF-mediated environment, scaffold design, and biofabrication technique. This chapter covers an overview of recent efforts that aim to promote vascularization in tissue engineering applications.

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Authors and Affiliations

  1. Wake Forest Institute for Regenerative Medicine Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC, USA

    Young Min Ju, Anthony Atala & James J. Yoo

Authors
  1. Young Min Ju
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  2. Anthony Atala
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  3. James J. Yoo
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Corresponding author

Correspondence to James J. Yoo .

Editor information

Editors and Affiliations

  1. Emeritus, Cardiovascular Surgery and Research, University Hospital and University of Geneva, Geneva, Switzerland

    Beat H. Walpoth

  2. Center for Biomedical Research, Medical University Vienna, Vienna, Austria

    Helga Bergmeister

  3. Department of Biomedical Engineering, University of Memphis, Memphis, TN, USA

    Gary L. Bowlin

  4. Key Laboratory of Bioactive Materials of the Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China

    Deling Kong

  5. Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands

    Joris I. Rotmans

  6. Chris Barnard Division of Cardiothoracic Surgery, Groote Schuur Hospital, University of Cape Town, Cape Town, Saudi Arabia

    Peter Zilla

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Ju, Y.M., Atala, A., Yoo, J.J. (2020). Vascularization of 3D Engineered Tissues. In: Walpoth, B.H., Bergmeister, H., Bowlin, G.L., Kong, D., Rotmans, J.I., Zilla, P. (eds) Tissue-Engineered Vascular Grafts. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-030-05336-9_22

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