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Synthetic Materials: Processing and Surface Modifications for Vascular Tissue Engineering

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Tissue-Engineered Vascular Grafts

Part of the book series: Reference Series in Biomedical Engineering ((TIENRE))

Abstract

Cardiovascular disease is a prominent issue in developed countries, notably the United States, and is expected to further escalate. As a result, the demand for “off the shelf” vascular grafts will concurrently increase. These readily available grafts for large vessels (>6 mm) are already on the market in the United States and Europe, but reliable products for small diameters vessels have eluded researchers and industry alike. In this chapter, the ideal attributes of a small diameter vascular graft are considered. Prominent synthetic polymers, subdivided into non-resorbable and resorbable, used in vascular grafts are covered. Each polymer’s history, bulk mechanical properties, degradation mechanisms, and notable implementation by researchers are discussed, followed by significant methods of fabrication to construct vascular grafts out of these materials. Subsequently, methods to modify graft surfaces and the materials that can be used to modify these surfaces are covered.

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Authors and Affiliations

  1. Department of Biomedical Engineering, University of Memphis, Memphis, TN, USA

    William E. King III, Benjamin A. Minden-Birkenmaier & Gary L. Bowlin

Authors
  1. William E. King III
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  2. Benjamin A. Minden-Birkenmaier
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  3. Gary L. Bowlin
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Correspondence to Gary L. Bowlin .

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Editors and Affiliations

  1. Emeritus, Cardiovascular Surgery and Research, University Hospital and University of Geneva, Geneva, Switzerland

    Beat H. Walpoth

  2. Center for Biomedical Research, Medical University Vienna, Vienna, Austria

    Helga Bergmeister

  3. Department of Biomedical Engineering, University of Memphis, Memphis, TN, USA

    Gary L. Bowlin

  4. Key Laboratory of Bioactive Materials of the Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China

    Deling Kong

  5. Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands

    Joris I. Rotmans

  6. Chris Barnard Division of Cardiothoracic Surgery, Groote Schuur Hospital, University of Cape Town, Cape Town, Saudi Arabia

    Peter Zilla

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King, W.E., Minden-Birkenmaier, B.A., Bowlin, G.L. (2020). Synthetic Materials: Processing and Surface Modifications for Vascular Tissue Engineering. In: Walpoth, B.H., Bergmeister, H., Bowlin, G.L., Kong, D., Rotmans, J.I., Zilla, P. (eds) Tissue-Engineered Vascular Grafts. Reference Series in Biomedical Engineering(). Springer, Cham. https://doi.org/10.1007/978-3-030-05336-9_2

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