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Transplant Adenovirus Infection: Clinical Syndromes, Diagnosis, and Management

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Abstract

Infections due to adenoviruses confer significant morbidity and mortality in immunocompromised hosts. Manifestations of disease in the setting of hematopoietic stem cell and solid organ transplantation may range from asymptomatic shedding or viremia to localized infection and disseminated disease. In solid organ transplant recipients, adenoviral disease often involves the allograft and can lead to graft dysfunction and/or graft loss. Several diagnostic methods are available for adenovirus infections, which include viral culture, direct antigen detection, molecular techniques, and histopathology. The cornerstone of treatment is the reduction of immunosuppression. Adjunct antiviral therapy is used if there is an inadequate clinical response to immunosuppression reduction. Immunotherapy is an option for those who fail to respond to established therapeutic options.

Keywords

Adenovirus Immunocompromised hosts Diagnosis Treatment 

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Authors and Affiliations

  1. 1.Section of Infectious Diseases, Department of Internal MedicineYale School of MedicineNew HavenUSA

Section editors and affiliations

  • Cameron R. Wolfe
    • 1
  1. 1.Duke UniversityDurhamUSA

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