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Magnetoencephalography pp 817–851Cite as

Towards the Understanding of Healthy and Pathological Aging Through MEG

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Abstract

The study of healthy and pathological aging with magnetoencephalography (MEG) has become more widespread in recent years. This is mainly because it is providing a new perspective in the study of this disease. Its excellent temporal resolution allows the evaluation of functional networks in the frequency domain. These characteristics make MEG unique for the study of the organization of the neurophysiological mechanisms supporting cognitive capabilities in the aging brain. In this chapter, we will review MEG findings in normal and pathological aging. In normal aging, we will go through the mechanisms of forgetting and the assessment of the default mode network organization. In the field of pathological aging, the literature has mainly focused on Alzheimer’s Disease (AD). These studies assess sensory memory, short-term and long-term memory, indicating decreased activity and connectivity in AD patients but a dual pattern of increased/decreased functional connectivity at early stages such as mild cognitive impairment (MCI) or subjective cognitive decline (SCD). Finally, similar results have been found in an extensive literature using resting state recordings which characterize the brain networks of patients with dementia in a non-task context. All these topics will be discussed in the context of the literature of cognitive neuroscience of aging. Potential new approaches and recommendations for future research will be provided.

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Authors and Affiliations

  1. Laboratory of Cognitive and Computational Neuroscience (UCM-UPM), Center for Biomedical Technology, Madrid, Spain

    Fernando Maestú & Ricardo Bajo

  2. Department of Experimental Psychology, Complutense University of Madrid, Madrid, Spain

    Fernando Maestú

  3. Department of Biological and Health Psychology, University Autónoma de Madrid, Madrid, Spain

    Elena Solesio-Jofre

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  1. Fernando Maestú
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  2. Elena Solesio-Jofre
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  3. Ricardo Bajo
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Correspondence to Fernando Maestú .

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  1. Faculty of Science, Department of Physics, University of Zagreb, Zagreb, Croatia

    Selma Supek

  2. Reno, NV, USA

    Cheryl J. Aine

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  1. The Mind Research Network, Albuquerque, NM, USA

    Julia M. Stephen

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Maestú, F., Solesio-Jofre, E., Bajo, R. (2019). Towards the Understanding of Healthy and Pathological Aging Through MEG. In: Supek, S., Aine, C. (eds) Magnetoencephalography. Springer, Cham. https://doi.org/10.1007/978-3-030-00087-5_28

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