Chemical Structure and When it was Licensed
Chemical name: 5-ethyldihydro-5-phenyl-4,6 (1H, 5H) pyrimidinedione.
The effectiveness of primidone in epilepsy was first demonstrated in 1949 (Whitty 1953). It was introduced a year later by the Imperial Chemical Industry (ICI) (now known as AstraZeneca) in the UK and Germany. In 1952, its effectiveness in the treatment of patients with idiopathic generalized epilepsy was demonstrated, and it was introduced in 1954 (as Mysoline®) by Wyeth in the USA (Williams 1956).
Mode of Action
Primidone has an anticonvulsant activity, as do its two main metabolites: Phenobarbital and Other Barbiturates and phenylethylmalonamide (PEMA) (El-Masri and Portier 1998) (Figs. 279-1 and 279-2 ). Primidone acts through interactions with voltage-gated sodium channels that inhibit high-frequency repetitive firing of action potentials (MacDonald and Kelly 1995).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Baciewicz AM (1986) Carbamazepine drug interactions. Ther Drug Monit 8:305–317
Bruno MK, Harden CL (2002) Epilepsy in pregnant women. Curr Treat Opt Neurol 4:3140
El-Masri HA, Portier CJ (1998) Physiologically based pharmacokinetics model of primidone and its metabolites phenobarbital and phenylethylmalonamide in humans, rats, and mice. Drug Metab Dispos 26:585–594
FDA (2009) Primidone official FDA information. http://www.fda.gov/cder/foi/label/2000/010401s013lbl.pdf (Accessed April 2009)
Gatti G, Furlanut M, Perucca E (2001) Interindividual variability in the metabolism of anti-epileptic drugs and its clinical application. In: Pacifici GM, Pelkonen O (eds) Interindividual variability in human drug metabolism. CRC Press, Boca Raton, p 168
Loiseau PJ (1999) Clinical experience with new antiepileptic drugs: antiepileptic drugs in Europe. Epilepsia 40(Suppl 6):S38
MacDonald RL, Kelly KM (1995) Antiepileptic drug mechanisms of action. Epilepsia 36(S2):S212
Madan A, Graham RA (2003) Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes. Drug Metab Dispos 31:42131
Martinez C, Gatti G, Sasso E, Calzetti S, Perucca E (1990) The disposition of primidone in elderly patients. Br J Clin Pharmacol 30:60711
Mattson RH, Cramer JA, Collins JF, Smith DB, Delgado-Escueta AV, Browne TR, Williamson PD, Treiman DM, McNamara JO, McCutchen CB et al. (1985) Comparison of carbamazepine, phenobarbital, phenytoin, and primidone in partial and secondarily generalized tonic-clonic seizures. NEJM 313:14551
Mehta KM (2008) British National Formulary. Pharmaceutical Press, London http://www.bnf.org
Schlienger RG, Shear NH (1998) Antiepileptic drug hypersensitivity syndrome. Epilepsia 39(S7):S37
Spina E, Perucca E (2002) Clinical significance of pharmacokinetic interactions between antiepileptic and psychotropic drugs. Epilepsia 43(S2):3744
Thomas SV (2006) Management of epilepsy and pregnancy. Postgrad Med 52(1):57–64
Whitty CW (1953) Value of primidone in epilepsy. BMJ 2(4835):5401
Williams D (1956) Treatment of epilepsy with mysoline. Proc R Soc Med 49:58991
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag London Limited
About this entry
Cite this entry
Mifsud, J. (2010). Primidone. In: Panayiotopoulos, C.P. (eds) Atlas of Epilepsies. Springer, London. https://doi.org/10.1007/978-1-84882-128-6_279
Download citation
DOI: https://doi.org/10.1007/978-1-84882-128-6_279
Publisher Name: Springer, London
Print ISBN: 978-1-84882-127-9
Online ISBN: 978-1-84882-128-6
eBook Packages: MedicineReference Module Medicine