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Diazepam

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Atlas of Epilepsies

Chemical Structure and When it was Licensed

Diazepam (7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one; C16H13ClN2O; molecular weight 284.75; pK a 3.2) is a 1,4 benzodiazepine (Clonazepam, Lorazepam, Midazolam) that was first synthesized in 1959 in the laboratory of Dr. Louis Sternbach at the Hoffman-La Roche facility in Nutley, New Jersey. It was trademarked as Valium in 1961 and a US patent was granted in 1968. Its chemical structure is displayed in Fig. 263-1 .

Figure 263-1
figure 1_263 figure 1_263

The chemical structure of diazepam and its metabolites. Temazepam and oxazepam undergo glucornidation prior to renal excretion

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Abbreviations

AAP:

American Academy of Pediatrics

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Authors and Affiliations

  1. Departments of Neurology and Pediatrics, University of Virginia, Charlottesville, VA, USA

    Howard P. Goodkin MD, PhD

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  1. Howard P. Goodkin MD, PhD
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Editors and Affiliations

  1. Department of Clinical Neurophysiology and Epilepsies, St. Thomas' Hospital, London, SE1 7EH, UK

    C. P. Panayiotopoulos PhD, FRCP (MD) (MD)

  2. Department of Neurosciences, John Radcliffe Hospital, Oxford, OX3 9DU, UK

    C. P. Panayiotopoulos PhD, FRCP (MD) (MD)

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Goodkin, H.P. (2010). Diazepam. In: Panayiotopoulos, C.P. (eds) Atlas of Epilepsies. Springer, London. https://doi.org/10.1007/978-1-84882-128-6_263

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  • DOI: https://doi.org/10.1007/978-1-84882-128-6_263

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