Anemia and the Heart
Delivery of oxygen and nutrients to organs and the peripheral tissues
Removal of metabolic waste products that accumulate throughout the body
Oxygen is carried by hemoglobin in the red blood cells to the tissues. The normal level of hemoglobin in circulating blood is 12–15.5 g/dL (120–155 g/L) in women and 15–17 g/dL (150–170 g/L) in men.
A normal structural heart with normal function usually can tolerate a hemoglobin level of 7 g/dL (70 g/L) for approximately 1 year without causing cardiac damage or heart failure. Hemoglobin level of 6 g/dL (60 g/L) or less may cause cardiac dysfunction after approximately 6 months. In patients with angina and hemoglobin <10 g/dL (100 g/L), chest pain may be precipitated because lack of oxygen to the myocardium produces myocardial ischemia that causes pain ( Heart Failure, Angina).
- Okonko DO, Grzeslo A, Witkowski T et al (2008) Effect of intravenous iron sucrose on exercise tolerance in anemic and nonanemic patients with symptomatic chronic heart failure and iron deficiency FERRIC-HF: a randomized, controlled, observer-blinded trial. J Am Coll Cardiol 51:103–112PubMedGoogle Scholar