Primary amyloidosis is now termed systemic AL amyloidosis, and cardiac involvement is not uncommon. On the other hand, secondary amyloidosis rarely affects the heart. The AL fibrils are derived from monoclonal immunoglobulin light chains. B-cell dyscrasias, mainly benign monoclonal gammopathies, followed by myeloma, macroglobulinemia, and lymphomas are the main causes of AL amyloidosis. Senile amyloidosis occurs mainly in individuals older than 80 years of age.
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