Encyclopedia of Heart Diseases

2011 Edition
| Editors: M. Gabriel Khan

Aspirin for Heart Disease

Reference work entry
DOI: https://doi.org/10.1007/978-1-60761-219-3_20


One does not have to believe in Adam and Eve to recognize the significance of an apple. The old saying “an apple a day keeps the doctor away” has been changed to “an aspirin a day keeps the doctor away” (Fig. 1). Worldwide, aspirin is the most used drug. The following pointers indicate why aspirin usage has increased:
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  1. Cairns JA, Gent M, Singer J et al (1986) Aspirin, sulfinpyrazone or both in unstable angina. N Engl J Med 313:1369Google Scholar
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Suggested Reading

  1. Craven LL (1953) Experiences with aspirin (acetylsalicylic acid) in the nonspecific prophylaxis of coronary thrombosis. Miss Val Med J 75:38Google Scholar
  2. Lewis HD, Davis JW, Archibald DG et al (1983) Protective effects of aspirin against acute myocardial infarction and death in men with unstable angina: Results of a Veterans Administration Cooperative Study. N Engl J Med 309:396PubMedGoogle Scholar
  3. Vane JN (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol 231:232–235PubMedGoogle Scholar

Case Studies

  1. Aronow HD, Califf RM, Harrington RA et al BRAVO Trial Investigators (2008) Relation between aspirin dose, all-cause mortality, and bleeding in patients with recent cerebrovascular or coronary ischemic events (from the BRAVO Trial). Am J Cardiol 102:1285–1290Google Scholar
  2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group (1988) Randomized trial of intravenous streptokinase, oral aspirin, both or neither among 17187 cases of suspected acute myocardial infarction. Lancet 11:349–350. ISIS-2Google Scholar
  3. Juul-Moller S, Edvardsson N, Jhnmatz B et al (1992b) Double-blind trial of aspirin in primary prevention of myocardial infarction in patients with stable chronic angina pectoris. Lancet 340:1421. The Swedish Angina Pectoris Aspirin TrialPubMedGoogle Scholar

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