Encyclopedia of Heart Diseases

2011 Edition
| Editors: M. Gabriel Khan

ACE Inhibitors/Angiotensin Receptor Blockers

Reference work entry
DOI: https://doi.org/10.1007/978-1-60761-219-3_2


Since their introduction in 1980, angiotensin-converting enzyme (  ACE) inhibitors, because of their unique pharmacologic properties, have proven superior to other vasodilators in the management of  heart failure and have come to play a key role in the therapy of hypertension. They are particularly useful in hypertensive patients with diabetes and  proteinuria and provide significant cardiovascular disease (CVD) protection. Angiotensin receptor blockers (ARBs) have the same clinical indications and are advisable when intolerance to ACE inhibitor therapy occurs. Their only advantages over ACE inhibitors are a much lower incidence of cough and angioedema; but a possibility remains that they may not possess equal beneficial effects, particularly on clinical outcomes despite the favorable results observed in some randomized clinical trials (RCTs).
  • The angiotensin receptor blocker telmisartan failed to prevent stroke in a well-run stroke RCT (PRoFESS 2008). In the large RCT...

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